DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and clec-2

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_494427.1 Gene:clec-2 / 181993 WormBaseID:WBGene00015198 Length:411 Species:Caenorhabditis elegans


Alignment Length:494 Identity:104/494 - (21%)
Similarity:164/494 - (33%) Gaps:169/494 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   474 FEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRI---------TAPDNHQVALKFQSFELE-- 527
            |.:|.|..|.:.||:|    |:     .|.|...|:         .|.||..|| .|...::|  
 Worm    25 FTLVNGKCLMMFKDES----NH-----DDAESFCRLFRGTLFDVKNAIDNRAVA-SFIGSQVETV 79

  Fly   528 -------KHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYI-------RFVSDSS 578
                   .::.|.:      |.|...:.....|.|..  |.:...|...|.       :::|...
 Worm    80 WMGLFCFNNNLCLW------DDNSGSTAAYDNFSGGY--PEVTIGSCVYYATQGTLAGKWISADC 136

  Fly   579 VQKLGFSAALMLDVDECKF-TDHGCQHLCINTLGSYQCGC----RAGYELQANGKTCEDACGGVV 638
            ..:..|         .|:. |.|  :..|.....:|   |    |..|........||:.||.:|
 Worm   137 TDRRSF---------VCETPTTH--EDSCYYNYNNY---CYTFHRDLYSFTTAQTICEEECGNLV 187

  Fly   639 DATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLN--------FSHFD--LEGTRFHYTKC 693
            ....:|.:.|                 |:...:|....|        ..|.:  ::||.:.|:..
 Worm   188 SIHSANENRY-----------------VMTIASHTTQANVLIGGMWPMDHVNTWVDGTMWDYSNI 235

  Fly   694 NYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDEC- 757
            :..|                                        |.|              :.| 
 Worm   236 DSGY----------------------------------------DPT--------------NHCI 246

  Fly   758 -SMNNGGCQHRCRNTFGSYQCSCRNGYTLA---ENGHNCT--------------ETRCKFEITTS 804
             ..||...::.....||   ..|::.|:..   ..|..|:              |:.|...:..:
 Worm   247 AMANNATSEYNLGQWFG---VDCKDYYSFVCKRPAGVPCSTDQPKVTVTPVPSNESFCNSTVLMT 308

  Fly   805 YGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLG 869
            .|::.|||||::|..|:||.:...|:..:.|.|.|..|..|.:    .|.|.:|||.|.|...:|
 Worm   309 PGIITSPNYPQNYDNNVYCSYKLSTLGSYNILLEFTSFSTEEN----VDLVTVYDGESTNGLKIG 369

  Fly   870 IYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVS 908
            .|.|.|||:.:|:..|..|:..:||:....|||.|:||:
 Worm   370 TYSGSREPFHLISKGNNFFLAFSTDSRNVFKGFSASFVA 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808
CUB 388..474 CDD:214483 104/494 (21%)
CUB 478..586 CDD:395345 26/132 (20%)
FXa_inhibition 595..630 CDD:464251 8/39 (21%)
CUB 634..750 CDD:395345 15/125 (12%)
FXa_inhibition 757..792 CDD:464251 8/39 (21%)
CUB 797..906 CDD:395345 39/108 (36%)
CUB 910..1023 CDD:395345
clec-2NP_494427.1 CLECT 21..145 CDD:214480 28/146 (19%)
CLECT 165..275 CDD:214480 26/183 (14%)
CUB 301..408 CDD:238001 40/110 (36%)
Blue background indicates that the domain is not in the aligned region.

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