DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tld and nas-10

DIOPT Version :9

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_001257126.1 Gene:nas-10 / 181287 WormBaseID:WBGene00003529 Length:540 Species:Caenorhabditis elegans


Alignment Length:217 Identity:62/217 - (28%)
Similarity:97/217 - (44%) Gaps:50/217 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 IPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKN----CGCCSFLGK-- 209
            |||..|:......:...:.|:...|..|||:|.........|:|.:...|    || .|::|:  
 Worm   311 IPYTFDSSLDNLDQNDVRGAISEIEQKTCIRFKYFASPPKGNHINYQKVNSPSFCG-LSYIGRVE 374

  Fly   210 ----------NGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQE 264
                      .||||            ||.:||..|.:|.:|:|.|.||||||.::..|| ..|:
 Worm   375 PANPVYLSFQCGNGR------------GIAVHETMHALGVNHQHLRMDRDKHIKVDWSNI-NPQQ 426

  Fly   265 YNFDVLSPEEVDLPL-LPYDLNSIMHYAKNSFSKS---------PYLDTITPIGIPPGTHLELGQ 319
            |:..|::..::.... :.|..:|||||  |:::.:         |.::....||:       |||
 Worm   427 YDAFVVADSKLYTTYGVKYAYDSIMHY--NAYTGAVNIAKPTMIPLVNQQANIGL-------LGQ 482

  Fly   320 RKRLSRGDIVQANLLYKCASCG 341
            |.::|..|:...|.:| |.|.|
 Worm   483 RAKMSNADVEILNKMY-CKSAG 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 59/212 (28%)
Astacin 144..339 CDD:279708 60/213 (28%)
CUB 388..474 CDD:214483
CUB 478..586 CDD:278839
FXa_inhibition 595..630 CDD:291342
CUB 634..750 CDD:278839
FXa_inhibition 757..792 CDD:291342
CUB 797..906 CDD:278839
CUB 910..1023 CDD:278839
nas-10NP_001257126.1 Astacin 303..501 CDD:396122 60/213 (28%)
ShK 503..540 CDD:396228 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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