DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-38

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001359993.1	Gene:	nas-38 / 180407	WormBaseID:	WBGene00003554	Length:	727	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	159/727 - (21%)
Similarity:	236/727 - (32%)	Gaps:	245/727 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 RTWD-YGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFL 207
            :.|| .|.|.::.........:...:.||..|:..||::|.|..||:.....:   ...||.||:
Worm   122 KKWDTRGPISFDYAESIPFQTRQKIRSAMLLWQQHTCLRFEEGGPNVDRLEFF---DGGGCSSFV 183

  Fly   208 GKNGNGRQPISIGR-NCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLS 271
            |:.| |.|.|||.. .|:..|||.||:||.:|..||.||.|:::||.||..||...:..||..:.
Worm   184 GRVG-GTQGISISTPGCDVVGIISHEIGHALGIFHEQARPDQERHIAINYNNIPLSRWNNFQAVG 247

  Fly   272 PEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPI-GIPPGTHLELGQRKRLSRGDIVQANLLY 335
            ....:...||||..|:|||....|:..||..||..: .:...|   :|||...|..|....|:.|
Worm   248 ENHAETYNLPYDTGSVMHYGPYGFASDPYTPTIRTLERVQQST---IGQRAGPSFLDYQAINMAY 309

  Fly   336 KCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGE 400
            .|
Worm   310 GC--------------------------------------------------------------- 311

  Fly   401 KVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAK 465
                         ::.|. |...:|:||.|.:......|.
Worm   312 -------------TESCA-DLPCLRNGYTHPNNCSMCACP------------------------- 337

  Fly   466 GYRGFKARF-------EVVCGGDLKLTKD-QSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQ 522
              .|...|:       ...|||.:..||: :.|.|||||..:..|.||.|.|.||...:|.::|:
Worm   338 --EGLSGRYCEQVYPSNAQCGGVIFATKEVKYITSPNYPDKFPIDTECNWIIAAPIEGRVFMEFE 400

  Fly   523 -SFELEKHDGCAYDFVEIRDGNHSDSRLIG-RFCGDKLPPNIKTRSNQMYIRFVSDSSVQKL--- 582
             .|:....|.|...:||::  .|||.||.| |:|...||.|          ||:|..:...:
Worm   401 GDFDFLCEDTCDKAYVEVK--YHSDKRLTGARYCCSLLPKN----------RFISFKNEMIIIMR 453

  Fly   583 -------GFSAALMLD-----------------VDECKFTDHGCQHLCINTLGSYQCGC--RAGY 621
                   ||.|....:                 :.|...|....:...:.:..:|....  |...
Worm   454 GYRSSGAGFKAKFWSNLGEPEGVSTPLPPTTAPLPEISETTQKPEPTTVQSTTTYTTAIPRRTAK 518

  Fly   622 E--------------LQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNH 672
            :              |.::..|.|..   .|.:| :..:.:.|:.|.......:.   ..|.|..
Worm   519 KQFFTRKPITIPLTPLTSSSTTTEST---TVSST-TQSTTWLPTEPSFATGETEI---TTASPTI 576

  Fly   673 AVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKI----GIYCGHELPPVVNSEQSILRL 733
            .:|.:.|..                           |..|    |:....:.|.::||.     |
Worm   577 TLFPSLSTI---------------------------LPPINSLAGVLPSTQAPDIINSV-----L 609

  Fly   734 EFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQC---SCRN------GYTLAENG 789
            |.......:..|          |||...|||.||.|..    :|   :||.      .::...:|
Worm   610 ECGCGAWSEWQG----------ECSQQCGGCGHRLRKR----ECKKEACRKEEKRPCNFSACPDG 660

  Fly   790 HNCTETRCKFEI 801
            .|......:|.|
Worm   661 TNFLINNAEFHI 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	67/196 (34%)
		Astacin	144..339	CDD:279708	68/197 (35%)
		CUB	388..474	CDD:214483	8/85 (9%)
		CUB	478..586	CDD:278839	41/120 (34%)
		FXa_inhibition	595..630	CDD:291342	4/50 (8%)
		CUB	634..750	CDD:278839	17/119 (14%)
		FXa_inhibition	757..792	CDD:291342	12/43 (28%)
		CUB	797..906	CDD:278839	2/5 (40%)
		CUB	910..1023	CDD:278839
nas-38	NP_001359993.1	Astacin	122..313	CDD:366617	68/273 (25%)
		CUB	367..466	CDD:214483	37/110 (34%)
		TSP1	613..658	CDD:214559	13/58 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810