DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and cubn-1

DIOPT Version :9

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_506157.3 Gene:cubn-1 / 179729 WormBaseID:WBGene00013855 Length:4047 Species:Caenorhabditis elegans


Alignment Length:1072 Identity:241/1072 - (22%)
Similarity:377/1072 - (35%) Gaps:310/1072 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 WDYGVIP---YEIDTIFSGA---HK---ALFKQAMRH------------------WENFTC---- 179
            ||:.:.|   |.....|.||   ||   .:|:.|.:|                  :..:.|    
 Worm  2749 WDFKMKPGFIYRFKITFPGANAYHKFDNQVFRIAKQHCFPDVAVVEGFPPYDGAQYSTYFCKNET 2813

  Fly   180 ---------------------IKFVERDPNLHAN-YIYFTV---------KNCGCCSFLGKNGNG 213
                                 |..:..|..|::. |..||:         :|.||...:.||   
 Worm  2814 QITSITDTIRIVYDDSHTREMISAIGNDQPLNSTFYAPFTIDYMAIPANSENQGCTLQINKN--- 2875

  Fly   214 RQPISIGRNCEKFGIIIHELGHTIGFH---HEHARG---DRDKHIVINKGNIMRGQEYNFDVLSP 272
                                 .|..||   ..:.:|   |...|:.|.|       ..||     
 Worm  2876 ---------------------LTTEFHLRNKVNGKGVGLDSFCHVSIEK-------PANF----- 2907

  Fly   273 EEVDLPLLPYDLNSIMHYA-KNSFSKSPYL----DTITPIG------------------IPPGTH 314
            |.|.:.:..|..:|.:..| ...||...:|    |...||.                  :.|...
 Worm  2908 ESVHIEISDYKADSELQPAGAKCFSWGAHLKIKSDEPVPIETTVCDGKSMKNKQSEMIYVNPQID 2972

  Fly   315 LELGQRKRLSRGDIVQANLLYKCASCGRTYQQ-NSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPS 378
            |.:.|..|...|.  |.||..:...||..... |:|.|.||:|   |:| |....||        
 Worm  2973 LFISQLFRDQEGQ--QFNLTIEFQKCGGVISSPNTGDITSPNF---GSG-LKYLPGS-------- 3023

  Fly   379 AESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVS 443
                      .|.|.:.|..|:.|.:.:.::.:....:|..|:|.|.:|.......:.:.|..:.
 Worm  3024 ----------KCRWVLEAPEGQIVKVKIVEMQIAYDHECENDHLIIGEGRQADVNTIHKYCHKMD 3078

  Fly   444 GE----------VITTQTSRMLLNYVNRNAAKGYRGFKARFEVV-----CGGDLKLTKDQS--ID 491
            ||          :|.:....:.|.:|. |......|:|.::|.:     ||..   |...|  |.
 Worm  3079 GEQEQKLEDRFKIIKSHGRYLTLIWVT-NMKYEEAGWKIQYEFLNENEECGYH---TSGMSGTIY 3139

  Fly   492 SPNY-PMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHS---------- 545
            :|.: ..||..|.||||.|..|..:.:.|||:.|::|..:.||.|.:.|.. .||          
 Worm  3140 TPMFGDKDYENDLECVWDIQVPLGYHINLKFKDFDVETAENCAKDQLLISQ-EHSTRANSPNGDY 3203

  Fly   546 -----DSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHL 605
                 |.......||.:.|.:.::.||::.:.|.:||.....||..                   
 Worm  3204 YFLFQDEEKETPLCGIEHPKDFESESNRVRLNFTTDSQTTARGFRV------------------- 3249

  Fly   606 CINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPP 670
                  :::..|.|.|.|                   ::|.:.||.||:.|||...|.: ::|||
 Worm  3250 ------NWEAECGAIYRL-------------------NHGVITSPYYPNGYPNDITCTY-LIAPP 3288

  Fly   671 --NHAVFLNFSHFDLE--GTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSIL 731
              |..:.:.|:.|||.  .|.|....|..|||.|.....|   :.:..:|..|..|         
 Worm  3289 DQNSVIAIKFADFDLATMRTSFGRAPCEDDYLQIIDTGTD---RVLHTFCASEPMP--------- 3341

  Fly   732 RLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETR 796
                 .|..|.:.....|||.|.....|...       |.:|.   ....|:.||.:.:.|.:..
 Worm  3342 -----KDALVFKGAIGLKFVSDKSYYWMEED-------NKYGR---KGSKGFQLAYSINKCGDNI 3391

  Fly   797 CKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGR 861
            ...|.|.....:.||.:|..|.:::.|.|:..|....::.:.|.:.::|:..:|..||:..:|..
 Worm  3392 ELREGTGFITTVTSPAFPLPYTKDLDCVWNITTDPNRQLNIRFEEMKLEAFHDCSADYIEFFDSS 3456

  Fly   862 S-ENSSTLGIYCGGRE---PYAVIASTNEMFMVLATDAGLQRKGFKATFVSE------CGGYLRA 916
            . ..:.|||.:||..:   .|.::.|...:.:.:.||..:...|||...:|.      |||.|.|
 Worm  3457 DIMANKTLGKFCGTMDKIPQYRIVTSGPNLLIHMRTDFNVNSGGFKLAVISSLGQKEGCGGKLTA 3521

  Fly   917 TNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHF---EIEY------SERCDYDYL 972
            |...||..| |:.....|...:.|.|.|....:|.::||....   ::||      |..| .|.|
 Worm  3522 TTSWQTLTS-PKDEDGNYPPALLCGWTISGPVDSQLQIRIDGVDTEQLEYPPGDRPSPEC-IDAL 3584

  Fly   973 EITE-EGYSMNTIHGRFC--GKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVG 1034
            .|.: :.:....:.|..|  |...|.|:.::.....:.|:||...:.|||.||:..||       
 Worm  3585 AIYDGQEFFSPLLAGDICTSGTPLPKILYTSHRHAFITFETDRDGTGRGFNISYSIVD------- 3642

  Fly  1035 EDFDAVTPFPGYLKS-------MYSSETGSDH 1059
                  :...|:||:       :|...|..|:
 Worm  3643 ------SDCGGWLKATNEIKTLVYKGITSDDN 3668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 53/282 (19%)
Astacin 144..339 CDD:279708 53/283 (19%)
CUB 388..474 CDD:214483 19/95 (20%)
CUB 478..586 CDD:278839 37/125 (30%)
FXa_inhibition 595..630 CDD:291342 4/34 (12%)
CUB 634..750 CDD:278839 30/119 (25%)
FXa_inhibition 757..792 CDD:291342 6/34 (18%)
CUB 797..906 CDD:278839 27/112 (24%)
CUB 910..1023 CDD:278839 36/124 (29%)
cubn-1NP_506157.3 EGF_CA 169..205 CDD:238011
EGF_CA 207..248 CDD:238011
EGF_CA 306..345 CDD:214542
EGF_CA 346..387 CDD:214542
EGF_3 392..429 CDD:372403
EGF_CA 443..475 CDD:238011
EGF 480..509 CDD:333761
CUB 645..762 CDD:238001
CUB 769..932 CDD:238001
CUB 1065..1181 CDD:238001
CUB 1210..1297 CDD:381774
CUB 1313..1424 CDD:214483
CUB 1428..1557 CDD:238001
CUB 1584..1676 CDD:214483
CUB 1691..>1733 CDD:381774
CUB 1964..2053 CDD:214483
CUB 2207..2332 CDD:238001
CUB 2350..2458 CDD:381774
CUB 2482..2585 CDD:214483
CUB 2603..2699 CDD:214483
CUB 2721..>2766 CDD:381774 4/16 (25%)
CUB 2996..3120 CDD:238001 32/146 (22%)
CUB 3127..3253 CDD:238001 37/154 (24%)
CUB 3264..3382 CDD:214483 39/145 (27%)
CUB 3387..3503 CDD:238001 27/115 (23%)
CUB 3515..3640 CDD:238001 37/126 (29%)
CUB 3672..3764 CDD:381774
CUB 3786..3899 CDD:238001
CUB 3918..4033 CDD:381774
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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