DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and nas-32

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_503351.3	Gene:	nas-32 / 178595	WormBaseID:	WBGene00003550	Length:	653	Species:	Caenorhabditis elegans

Alignment Length:	676	Identity:	144/676 - (21%)
Similarity:	228/676 - (33%)	Gaps:	216/676 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VPPKEPKDDIYQL--------KTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHS 123
            |||::.|..:.::        |.|::.|.:    .|||..|..:...||      |:|:.:.:..
Worm   114 VPPEKRKKQLKKMGKKMMKIPKITKKESNK----LHKSYRKVKITENPP------ALDMFEVNER 168

  Fly   124 PTLNGQPIQ---------------------RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALF 167
            ..||....|                     ||::.......:.|...|:.|..|:..:...:.:.
Worm   169 AGLNEYLFQGDINLNNNQIAKISSEQSSKSRRKKRQIDNLAQFWPGKVVYYYFDSGLTTTVQQIV 233

  Fly   168 KQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHE 232
            :.|:...|:.||:||   :.|..|..........||.|..|..| |.|.:|:|..||..|...||
Worm   234 RDAITFLESNTCLKF---ELNSTATNRVKIFSGVGCYSDTGMLG-GEQTLSLGYGCEVTGTAAHE 294

  Fly   233 LGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSK 297
            :.||:|..|...|.|||.::.|:..::....:.||..|: |.....|:.|:..|.|||:..:|..
Worm   295 IAHTLGLFHTQMRSDRDDYVTIDLTDVPESSQQNFIKLT-EATSTNLVDYEYGSFMHYSGRAFVS 358

  Fly   298 SPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCA-----SCGR---TYQQNSGHIVSP 354
            |..:|:|.|  ..|.....:|.| .::..|:...|..|.|:     |||.   |...|....:.|
Worm   359 SGGVDSIVP--KDPVMVYTMGGR-IVTFLDLKMLNTHYSCSCPTILSCGNGGFTNPANCSVCICP 420

  Fly   355 HFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQ 419
            :..  |..:.:|....|                  |...:|||:
Worm   421 YGF--GGALCTERTDYG------------------CGSTLTATD--------------------- 444

  Fly   420 DYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKL 484
                    .|.:....   .||.|    .:.|:|....|.|.
Worm   445 --------TWQQETYT---FGNAS----NSATARPSAVYCNH----------------------- 471

  Fly   485 TKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQS-FELEKHDGCAYDFVEIRDGNHSDSR 548
                                  | |.||...|:..:..| :..:...||.::.||.:  ..||..
Worm   472 ----------------------W-IQAPVGKQIQFRIDSTYNTQCVYGCTFNGVEPK--LKSDMT 511

  Fly   549 LI-GRFCGDKLPPNIKTRS-----------NQMY-------IRFVSDSSVQKLGFSA--ALMLDV 592
            :. .|:|.|:....|.|..           |:.|       .|:| ||:|.....::  |..|.:
Worm   512 ITQARYCCDEFNAEIMTADFGVNPMPVFSFNRYYKTTYTWSYRYV-DSNVTACADTSDKATCLSL 575

  Fly   593 DECKFTDHGC--------QHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYS 649
            ...|  :.||        :.:|..|:.  .||     ::.::..||:|.      ..||..|.||
Worm   576 KSAK--EQGCSIYDTAQLKVMCAATMD--LCG-----KVASDDGTCKDR------FPKSQCSTYS 625

  Fly   650 PSYPDVYPNSKQCVWEVVAPPNHAVF 675
                    .:..|..:   ||..|.|
Worm   626 --------TNGMCTQQ---PPLAAEF 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	56/200 (28%)
		Astacin	144..339	CDD:279708	57/199 (29%)
		CUB	388..474	CDD:214483	12/85 (14%)
		CUB	478..586	CDD:278839	24/127 (19%)
		FXa_inhibition	595..630	CDD:291342	7/42 (17%)
		CUB	634..750	CDD:278839	10/42 (24%)
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-32	NP_503351.3	Astacin	210..397	CDD:279708	57/194 (29%)
		ZnMc_astacin_like	214..393	CDD:239807	54/186 (29%)
		CUB	464..>528	CDD:294042	18/111 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810