DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and toh-1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_497769.3	Gene:	toh-1 / 175491	WormBaseID:	WBGene00006591	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	467	Identity:	110/467 - (23%)
Similarity:	179/467 - (38%)	Gaps:	141/467 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 TLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAH--KALFKQAMRHWENFTCIKFVERDP 187
            |::...:.|.||.|...:...|:...||::   |:.|.:  ::|.::.:|.||:.||::|.|...
Worm    50 TVSRTKVHRHRREVIAGQIYDWNSYEIPFQ---IWGGDYNFQSLIRRGIRMWEDSTCLRFKENQQ 111

  Fly   188 NLHANYIYFTVKNCGCC--SFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDK 250
            :..|  |.:.::....|  .::|:|| |.|.|.||..|.:..::.||.||.:||.|.|.|.|||:
Worm   112 SRDA--IRYVLEKGDSCFTEYIGRNG-GHQDIIIGSECAEEYVVAHETGHALGFWHTHQRPDRDR 173

  Fly   251 HIVINKGNIMRG------------QEYNFDVLSPEEVDLPLLPYDLNSIMHY--AKNSFSKSPYL 301
            ||.||..|:|..            |.:....:||..|     |||..|:|||  ..::...|.:
Worm   174 HISINWKNVMEEATASFMPFRSMLQAFGIRQVSPRRV-----PYDYGSLMHYHAVAHAVKVSDF- 232

  Fly   302 DTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSE 366
             ||.|..:...|  .:|..| ::..|....|.:|...:|     |...|:         |.:...
Worm   233 -TIVPKELKYVT--TMGTEK-MAFLDAKVINDIYCPNAC-----QGRNHL---------NCLAGG 279

  Fly   367 FEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHK 431
            :       .||:     :.::..|      ..|            :...||         |....
Worm   280 Y-------PDPN-----NCNVCRC------PEG------------LGGPDC---------GRLQP 305

  Fly   432 SPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKD-QSIDSPNY 495
            ||                                            |||::..:.. |::.||:
Worm   306 SP--------------------------------------------CGGEIHASDQWQTLSSPS- 325

  Fly   496 PMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIG-RFCGDKLP 559
                ..|..|.|||:.|:..:|..:....|.....|| ..:|||:  :..|.||.| |.|..:..
Worm   326 ----GRDVHCYWRISVPEGSRVRFRLSDGEFPCSYGC-QSYVEIK--HKLDVRLTGFRSCCYRPK 383

  Fly   560 PNIKTRSNQMYI 571
            .:..:.|||:::
Worm   384 EDTVSESNQIFV 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	65/218 (30%)
		Astacin	144..339	CDD:279708	64/212 (30%)
		CUB	388..474	CDD:214483	7/85 (8%)
		CUB	478..586	CDD:278839	28/96 (29%)
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
toh-1	NP_497769.3	Astacin	71..265	CDD:279708	64/209 (31%)
		ZnMc_astacin_like	73..262	CDD:239807	62/204 (30%)
		CUB	320..410	CDD:214483	24/84 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810