DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and Mep1a

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_032611.2	Gene:	Mep1a / 17287	MGIID:	96963	Length:	760	Species:	Mus musculus

Alignment Length:	754	Identity:	174/754 - (23%)
Similarity:	259/754 - (34%)	Gaps:	195/754 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 IQRRRRAVTVRKERTWDYGVIPYEI-DTIFSGAHKALFKQAMRH-WENF---TCIKFVERDPNLH 190
            :.|.|.|:.....| |.. .|||.: |.:...|     |.|:.| :|.|   :|:.|...:.  .
Mouse    73 LPRTRNAMRDPSSR-WKL-PIPYILADNLELNA-----KGAILHAFEMFRLKSCVDFKPYEG--E 128

  Fly   191 ANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVIN 255
            ::||.|. |..||.|.:|....| |.||||..|:....|.||:.|.:||.||.:|.|||.::.|.
Mouse   129 SSYIIFQ-KLSGCWSMIGDQQVG-QNISIGEGCDFKATIEHEILHALGFFHEQSRTDRDDYVNIW 191

  Fly   256 KGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQR 320
            ...|:...|:||:......:.....|||..|:|||...||:|:..:.||| ..||....: :||.
Mouse   192 WDQIITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPTIT-TKIPEFNTI-IGQL 254

  Fly   321 KRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGD----AGEDPSAES 381
            ...|..|:::.|.:|.|.:.         |.:..|..:....|....:|:.|    |..|.|...
Mouse   255 PDFSAIDLIRLNRMYNCTAT---------HTLLDHCDFEKTNVCGMIQGTRDDADWAHGDSSQPE 310

  Fly   382 EFDASLT-NCEW--------RITATNGEKVILHLQQLHLMSSDDCTQDYLEI------RDGYWHK 431
            :.|.:|. .|:.        ......||..:|..:.|:......|.|.:.::      |...|
Mouse   311 QVDHTLVGQCKGAGYFMFFNTSLGARGEAALLESRILYPKRKQQCLQFFYKMTGSPADRFEVW-- 373

  Fly   432 SPLVRR--ICGNVSGEVITTQT------SRMLLNYVNRNAAKGYR----GFKARFEVVCGG---- 480
               |||  ..|.|. ::...||      ....:.:|..|..|.:|    |.|.......||
Mouse   374 ---VRRDDNAGKVR-QLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFLGTKGDPGNSSGGIYLD 434

  Fly   481 DLKLTKDQSIDSPNYPMDYMPDKECVWRI---------TAPDNHQVALKFQSFELEKHDGCAYDF 536
            |:.||:             .|....||.|         |...:..|:.:|.:.|
Mouse   435 DITLTE-------------TPCPAGVWTIRNISQILENTVKGDKLVSPRFYNSE----------- 475

  Fly   537 VEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYI-----RFVSDSSVQKLGFSAALMLDVDECK 596
                          |...|..|.||.:..||..::     .:..|:       .|.|...|:
Mouse   476 --------------GYGVGVTLYPNGRITSNSGFLGLTFHLYSGDN-------DAILEWPVE--- 516

  Fly   597 FTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLY--SPSYPDVYPNS 659
                  ....|.|:...:...|....|.....|.::.....:     |||:.  .||...||...
Mouse   517 ------NRQAIMTILDQEADTRNRMSLTLMFTTSKNQTSSAI-----NGSVIWDRPSKVGVYDKD 570

  Fly   660 KQCV----WEVVAPPNHAVF--LNFSHFDLEGTRFHYTKCNYDYLIIYSKMRD----NR------ 708
            ..|.    |......:|.:.  .||    |:|          |.|||:...:|    ||
Mouse   571 CDCFRSLDWGWGQAISHQLLKRRNF----LKG----------DSLIIFVDFKDLTHLNRTEVPAS 621

  Fly   709 ----LKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVID--------------VD 755
                :.:..:..|.|.|.:..|.:..:..|.......||.....|..::              .|
Mouse   622 ARSTMPRGLLLQGQESPALGESSRKAMLEESLPSSLGQRHPSRQKRSVENTGPMEDHNWPQYFRD 686

  Fly   756 ECSMNNGGCQHR--CRNTFGSYQCSCRNGYTLAENGHNC 792
            .|..|  .||:.  |.|..|...|.|.:|:.....|..|
Mouse   687 PCDPN--PCQNEGTCVNVKGMASCRCVSGHAFFYAGERC 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	68/205 (33%)
		Astacin	144..339	CDD:279708	68/199 (34%)
		CUB	388..474	CDD:214483	22/112 (20%)
		CUB	478..586	CDD:278839	21/125 (17%)
		FXa_inhibition	595..630	CDD:291342	4/34 (12%)
		CUB	634..750	CDD:278839	28/137 (20%)
		FXa_inhibition	757..792	CDD:291342	11/36 (31%)
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Mep1a	NP_032611.2	ZnMc	46..271	CDD:381785	70/210 (33%)
		MAM	281..444	CDD:366209	36/181 (20%)
		MATH	443..607	CDD:351761	41/223 (18%)
		EGF	688..722	CDD:333761	11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810