Protein Alignment tld and nas-36

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_492109.2
• Gene: nas-36 / 172506
• WormBaseID: WBGene00003552
• Length: 617
• Species: Caenorhabditis elegans
• Alignment Length: 728
• Identity: 175/728 - (24%)
• Similarity: 254/728 - (34%)
• Gaps: 262/728 - (35%)

  Fly    50 DFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGR----------RRKQSHKSQNKAALRL 104
            :|||.    |.:.:..|...:|....:.:|..:|...||          :::.:..:|.....:.
 Worm    32 EFKEH----FNVEEKQLETVEELLIKMKKLAHSRSFKGREFGHDAVEDSKKEVAISTQQGTINKK 92

  Fly   105 PPPFLWTDD-------AVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGA 162
            ..|||:..|       |||:|:     .|:....:|.||:....|..||....|.|..
 Worm    93 VSPFLFEGDIFLSRRQAVDILK-----ALSKDKTKRLRRSFVSDKTATWKTMPIKYRF------- 145

  Fly   163 HKAL-------FKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIG 220
            |:::       ...|:|.||:.|||.|.....:...:||.| ....||.|.:|:|| |||.||||
 Worm   146 HESIDFYTISQIIAAIRFWEDSTCITFENVSDSPDGDYIEF-FSGQGCYSMIGRNG-GRQGISIG 208

  Fly   221 RNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLS-PEEVDLPLLPYDL 284
            .:|.|.|:|.||:||.:|..||.:|.|...::.|.:..|:  ..|..|.|. .:|:|...:||||
 Worm   209 ESCVKMGVIEHEIGHALGLWHEQSRPDALGYVTIERDFIL--PSYISDFLQRDDEIDTLGIPYDL 271

  Fly   285 NSIMHYAKNSFS-----------KSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCA 338
            .|:|||...:||           .|.|..||             |||::||..|:...|..|
 Worm   272 GSVMHYGSTAFSVDQKSKTVVTRDSLYQQTI-------------GQREKLSFYDVATINTAY--- 320

  Fly   339 SCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVI 403
                                                    .:.|..:..|.||      ||
 Worm   321 ----------------------------------------CKDECKSEKTKCE------NG---- 335

  Fly   404 LHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRIC-GNVSGEVITTQTSRMLLNYVNRNAAKGY 467
                                   ||...|.....:| ..:.||       :...|..::||.
 Worm   336 -----------------------GYMRPSKCSECLCPDGLGGE-------KCEKNEDSKNAE--- 367

  Fly   468 RGFKARFEVVCGGDLKLTKD-QSIDSPNYP-MDYMPDKECVWRITAPDNHQVALKF-QSFELEKH 529
                      |||.:|||:: :.|:||||| ..|..|::|.|.:.|....:|.::| :.|.....
 Worm   368 ----------CGGIIKLTEEWKEIESPNYPDPGYEADQKCSWLLKAEKGKRVEIEFIEDFSFLCT 422

  Fly   530 DGCAYDFVEIRDGNHSDSRLIG-RFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVD 593
            ..|. ||||::..:  |.|..| |||....|.          |.|||.:....:.|.:.|..|:.
 Worm   423 STCV-DFVELKISD--DLRNTGFRFCCYDKPE----------ISFVSQTDTAIIIFRSQLSTDIG 474

  Fly   594 ---ECKFT-----------------------------DHGCQHLCINTLGSYQCGCRAGYELQAN 626
               :.|.|                             |.|...:|..|.|.  ||.|:... ...
 Worm   475 FKIQAKSTDAEPRTTIAPTIITTTLAPITVDAPNVWADWGEWSMCSRTCGG--CGIRSRVR-SCR 536

  Fly   627 GKTCED---------------------------ACGGVVDATKSNGSLYSPSYPDVYPNSKQCVW 664
            .|.||.                           .|.|.| .||::.::.|...|       ||
 Worm   537 SKKCEGRRQEFGTCNLKACPVDKHCAKLLSNNRLCNGKV-CTKNDIAISSCDAP-------QC-- 591

  Fly   665 EVVAPPNHAVFLN 677
               .||    |:|
 Worm   592 ---CPP----FIN 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	72/219 (33%)
		CUB	388..474	CDD:214483	14/86 (16%)
		CUB	478..586	CDD:395345	37/111 (33%)
		FXa_inhibition	595..630	CDD:464251	11/63 (17%)
		CUB	634..750	CDD:395345	13/44 (30%)
		FXa_inhibition	757..792	CDD:464251
		CUB	797..906	CDD:395345
		CUB	910..1023	CDD:395345
nas-36	NP_492109.2	Astacin	134..323	CDD:426242	71/255 (28%)
		CUB	380..478	CDD:214483	33/110 (30%)
		TSP1	510..556	CDD:214559	11/48 (23%)