DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tld and Fbn1

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_032019.2 Gene:Fbn1 / 14118 MGIID:95489 Length:2873 Species:Mus musculus


Alignment Length:626 Identity:138/626 - (22%)
Similarity:217/626 - (34%) Gaps:152/626 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   361 NGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHL----MSSDDCTQDY 421
            |||.....||...  :.|.||..|.:.|.|...|..|..:.||....::::    :.|:.|:.  
Mouse   820 NGVCKNSPGSFIC--ECSPESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSECCSS-- 880

  Fly   422 LEIRDGYWHKSPL----VRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGF---------KAR 473
               ....| .||.    :..|||.....:..||...:       |..:.:.|.         :..
Mouse   881 ---LGAAW-GSPCTICQLDPICGKGFSRIKGTQCEDI-------NECEVFPGVCKNGLCVNSRGS 934

  Fly   474 FEVVCGGDL------KLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGC 532
            |:..|...:      ::..|..:::.....|   |:||...|..  .|::            |.|
Mouse   935 FKCECPNGMTLDATGRICLDIRLETCFLKYD---DEECTLPIAG--RHRM------------DAC 982

  Fly   533 ------AYDFVEIRDGNHSDSRLIGRFCGDKLP--PNIKTRSNQMYIRFVSDSSVQKLGFSAALM 589
                  |:...|..:....:||.....|    |  |...|:          |.:..|..|.    
Mouse   983 CCSVGAAWGTEECEECPLRNSREYEELC----PRGPGFATK----------DITNGKPFFK---- 1029

  Fly   590 LDVDECKFTDHGCQH-LCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYP 653
             |::|||.....|.| .|.||:||::|.|.:|:.|.:..:.|.|     :|..:.:..|......
Mouse  1030 -DINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTD-----IDECRISPDLCGRGQC 1088

  Fly   654 DVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYC-- 716
            ...|...:|..:........:..|....|         :|..|.|:....:..|........|  
Mouse  1089 VNTPGDFECKCDEGYESGFMMMKNCMDID---------ECQRDPLLCRGGICHNTEGSYRCECPP 1144

  Fly   717 GHELPPVVNSEQSILRLEFYSD-----RTVQRSGFVAK----------------FVIDVDECSMN 760
            ||:|.|.:::...|...|..::     |.|   ..:.|                |.:|:||||:.
Mouse  1145 GHQLSPNISACIDINECELSANLCPHGRCV---NLIGKYQCACNPGYHPTHDRLFCVDIDECSIM 1206

  Fly   761 NGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTE-TRCKFEITTSYGVLQSPNYPEDYPRNIYCY 824
            ||||:..|.|:.|||:|||:.|:.|..:..:||: ..|:.......|. |..|.|.:|  ...||
Mouse  1207 NGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGG-QCTNIPGEY--RCLCY 1268

  Fly   825 WHF-------------QTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSE-------NSSTLG 869
            ..|             :..|...|.|:......:....|..|..  |.|:..       |...:|
Mouse  1269 DGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMG--YSGKKGKTGCTDINECEIG 1331

  Fly   870 IYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSEC 910
            .:..||  :||..:|...|. .:...|....|.|.|.:.||
Mouse  1332 AHNCGR--HAVCTNTAGSFK-CSCSPGWIGDGIKCTDLDEC 1369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808
CUB 388..474 CDD:214483 18/102 (18%)
CUB 478..586 CDD:395345 21/121 (17%)
FXa_inhibition 595..630 CDD:464251 13/35 (37%)
CUB 634..750 CDD:395345 20/138 (14%)
FXa_inhibition 757..792 CDD:464251 16/34 (47%)
CUB 797..906 CDD:395345 27/128 (21%)
CUB 910..1023 CDD:395345 1/1 (100%)
Fbn1NP_032019.2 Fibrillin_U_N 48..82 CDD:436338
TB 194..>227 CDD:459903
EGF_CA 246..>276 CDD:214542
EGF_CA 288..329 CDD:214542
TB 343..389 CDD:459903
EGF_CA 492..523 CDD:214542
EGF_CA 532..573 CDD:214542
EGF_CA 574..614 CDD:214542
EGF_CA 615..648 CDD:214542
TB 670..713 CDD:459903
EGF_CA 767..>798 CDD:214542
TB 862..>892 CDD:459903 5/35 (14%)
TB 968..1010 CDD:459903 10/55 (18%)
EGF_CA 1072..1106 CDD:214542 5/38 (13%)
EGF_CA 1115..1151 CDD:214542 9/44 (20%)
EGF_CA 1157..1192 CDD:238011 5/37 (14%)
FXa_inhibition 1203..1238 CDD:464251 16/34 (47%)
EGF_3 1328..1363 CDD:463759 9/37 (24%)
EGF_3 1369..1404 CDD:463759 1/1 (100%)
EGF_CA 1448..1488 CDD:214542
EGF_CA 1489..1520 CDD:214542
TB 1551..1591 CDD:459903
EGF_CA 1608..1640 CDD:214542
EGF_CA 1650..1689 CDD:214542
TB 1707..1750 CDD:459903
EGF_CA 1768..1798 CDD:429571
EGF_CA 1810..1842 CDD:214542
EGF_CA 1932..1974 CDD:214542
EGF_CA 1975..2010 CDD:238011
EGF_CA 2015..2045 CDD:429571
TB 2070..2113 CDD:459903
EGF_CA 2129..2167 CDD:214542
EGF_CA 2168..2207 CDD:214542
TB <2359..2392 CDD:459903
vWFA <2444..2484 CDD:469594
EGF_CA 2487..2516 CDD:429571
EGF_CA 2526..2568 CDD:214542
EGF_CA 2569..>2598 CDD:214542
EGF_CA 2609..2640 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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