Protein Alignment tld and LOC1276210

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: XP_061508399.1
• Gene: LOC1276210 / 1276210
• VectorBaseID: AGAMI1_007077
• Length: 3766
• Species: Anopheles gambiae
• Alignment Length: 1045
• Identity: 247/1045 - (23%)
• Similarity: 394/1045 - (37%)
• Gaps: 281/1045 - (26%)

  Fly   188 NLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHAR----GDR 248
            |...:|      .||.|. .|..|:||..::.|..|            |.|..|..||    |..
Mosquito   345 NTRGSY------RCGNCP-AGYTGDGRTCLAQGNRC------------TQGLCHPMARCVDYGSA 390

  Fly   249 DKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLD--TITPI---- 307
            ..:.:...|.|..|                   :..|.....:.|..:.:|..:  |.|.|
Mosquito   391 VPNCICLPGYIGSG-------------------FGPNGCYRSSMNPCASAPCRNGGTCTKIDAQN 436

  Fly   308 ---GIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIV----SPHFI------YS 359
               ..||||:               ..|.:...:.|.....||.|..|    :.:|:      |:
Mosquito   437 YSCACPPGTN---------------PPNCMRTTSPCESNPCQNGGTCVGSSGTRNFLCRCPAGYT 486

  Fly   360 G----------NGVLSEFEGSGDAGEDPSAESEFDASLTN---CEWRITATNGEKVILHLQQLHL 411
            |          .|:  .|:.||..     ...||:.:..:   |.|.|.....:.:.:...|..|
Mosquito   487 GLRCQTPTRTCGGI--RFQMSGTL-----RYPEFNGTYNHNARCAWLIKTNETQVLNVTFTQFSL 544

  Fly   412 ---MSSDDCTQDYLEIRDGYWHKSPLVRRICGNV---SGEVITTQTSRMLLNYVNRNAAKGYRGF 470
               :||.:|..|:|:|.||....:.::.|.|||.   .|..  ..|..||..:...:.|..:.||
Mosquito   545 ENPVSSGECKYDWLQIHDGRTSAAQIIGRFCGNELPRGGNF--QSTHNMLYLWFRSDNATAHDGF 607

  Fly   471 KARFE---VVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGC 532
            :.|:|   .||||.:.......|.||..|.:|.|:::|.|.:.||...::...|.:.::|.|:.|
Mosquito   608 QLRWESIDPVCGGTIAAVSHGLIASPGTPGNYPPNRDCKWYLQAPQGRRLQFTFFTMKIEVHETC 672

  Fly   533 AYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSA--ALMLDVDEC 595
            .:|::||.||...:..|:.::|....||.:.|.||:..:.|.||.|....||..  |::..|..|
Mosquito   673 GFDYLEITDGLRDEGTLLAKYCNTSHPPPLITPSNEATVHFHSDESGNDAGFQIHYAVVEGVPGC 737

  Fly   596 ---------------KFTDH------GCQHLCINTLGS------------YQCGCRAGY------ 621
                           ..||:      .|::|....:||            ....|:..|
Mosquito   738 GGTYTQREGVISSPLSQTDNVYPNNLNCEYLIKQPVGSRVEIRFSKFHLEQSEACKFDYLEIFDG 802

  Fly   622 ---ELQANGKTCED----------------------------------ACGGVVDATKSNGSLYS 649
               |..:.||.|.|                                  .|||..  |.....|.|
Mosquito   803 PSTEDPSLGKFCGDRMPPLFTSTGNALLLKFHTDWSAPNPGFSLVYKIKCGGTF--TDPAVELIS 865

  Fly   650 PSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGI 714
            ||||.:||:.:.|.:.:.||...|:.|:|..||.|...|  .||..||:.:|..:.......:|.
Mosquito   866 PSYPQMYPSDQLCDYVIHAPLGKAIVLDFQDFDFEKNSF--PKCELDYVELYDGLLPTNETLLGR 928

  Fly   715 YCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECS--------------------- 758
            ||..:.||...|.:::|.|.|.||.:|...||...|......|.
Mosquito   929 YCSTKAPPQTISSKNVLLLRFVSDGSVSGRGFKGNFSFHDVSCGGVLMREDTIIRSPMIAETGKY 993

  Fly   759 MNNGGCQ--------HRCRNTFGSYQ----------------------------C---------- 777
            .::..|:        |..:.|:.|::                            |
Mosquito   994 QHDAQCEWIIVAPAGHAVQLTWNSFELEVSAWCVYDYVQVFDNSSMANSLVGRYCGTEKPPAITS 1058

  Fly   778 --------------SCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQ 828
                          |.::|::|:.|..: .|..|......:.|:::||.:|::||.|..|.|...
Mosquito  1059 TGNMVTIRFVTDSSSSKDGFSLSFNFID-VEKSCGGNFFATSGIIRSPGWPKNYPSNKVCEWVIT 1122

  Fly   829 TVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLAT 893
            ..:|.:|.|..|.|::|.|:.|.:|.:.|.:|.::|:..:|.|||.......|:.::::::...:
Mosquito  1123 VPMGQQIMLLVHSFKMEKHRICRFDGLTIRNGGTQNAPLIGNYCGEDNFNGTISFSHQLYLRFYS 1187

  Fly   894 DAGLQRKGFKATFVSE---CGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIR 955
            |:.....||...:.|.   |||.|.:...|....::|    .||.:|..|.|||.....|::.|.
Mosquito  1188 DSSRNYAGFMIEWDSATTGCGGILTSPRGSIISPNYP----LPYGQNALCTWRISMSQGSAIHIV 1248

  Fly   956 FLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDT--LLLRFQTDESNSLRG 1018
            |...::|..:.|.||||:|.:...:.....||||.....||:: ::||  .|:|.:|||:|..||
Mosquito  1249 FTDMDMESHKDCQYDYLDIYDGIDTSGRKLGRFCSAETDPIVL-DTDTNHALIRMRTDETNQRRG 1312

  Fly  1019 FAISF 1023
            |.:.:
Mosquito  1313 FQLKY 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	31/162 (19%)
		CUB	388..474	CDD:214483	24/94 (26%)
		CUB	478..586	CDD:395345	35/107 (33%)
		FXa_inhibition	595..630	CDD:464251	12/76 (16%)
		CUB	634..750	CDD:395345	41/115 (36%)
		FXa_inhibition	757..792	CDD:464251	10/115 (9%)
		CUB	797..906	CDD:395345	30/108 (28%)
		CUB	910..1023	CDD:395345	40/114 (35%)
LOC1276210	XP_061508399.1	None