Protein Alignment tld and Bmp1

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_033885.2
• Gene: Bmp1 / 12153
• MGIID: 88176
• Length: 991
• Species: Mus musculus
• Alignment Length: 1050
• Identity: 426/1050 - (40%)
• Similarity: 613/1050 - (58%)
• Gaps: 105/1050 - (10%)

  Fly     7 MPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKE 71
            ||...:..|.:||:..|  ::..|:..| ||.| .|.:...|...::.||         |:..|:
Mouse     1 MPGVARPPLPLLSLPLL--LLLLLLPRA-GRPL-DLADYTYDLGEEDAPE---------LLNYKD 52

  Fly    72 P-------------KDD-----IYQLKTTRQHSGRRRKQSHKSQ-NKAALRLPPPFLWTDDAVDV 117
            |             ::|     :.|....||.:.||  .|.|:. |.:||
Mouse    53 PCKAAAFLGDIALDEEDLRAFQVQQAAVLRQQTARR--PSIKAAGNSSAL--------------- 100

  Fly   118 LQHSHSPTLNGQPIQ----------RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMR 172
                .....:|||.:          |.|||.|.|.||.|..||||:.|...|:|:.:|:|:||||
Mouse   101 ----GGQGTSGQPQRESRGRWRGRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMR 161

  Fly   173 HWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTI 237
            |||..||:.|:||..  ..:||.||.:.|||||::|:.|.|.|.||||:||:||||::|||||.|
Mouse   162 HWEKHTCVTFLERTD--EDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVI 224

  Fly   238 GFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLD 302
            ||.|||.|.|||:|:.|.:.||..||||||..:..:||:.....||.:||||||:|:||:..:||
Mouse   225 GFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLD 289

  Fly   303 TITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEF 367
            ||.|.....|....:|||.|||:|||.||..||||.:||.|.|.::|:..||.:   .||
Mouse   290 TIVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEY---PNG----- 346

  Fly   368 EGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKS 432
                           :.|.: :|.|||:.|.|||:||:...:.|..|..|..||:|:|||:|.|:
Mouse   347 ---------------YSAHM-HCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFWRKA 395

  Fly   433 PLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYP 496
            ||..|.||....|.|.:..||:.:.:.:.:...| :||.|.:|.:||||:|  ||.. |.|||||
Mouse   396 PLRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVG-KGFFAVYEAICGGDVK--KDNGHIQSPNYP 457

  Fly   497 MDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPN 561
            .||.|.|.|:|||...:...|.|.|||||:|:||.||||::|:|||:...|.||||:||.:.|.:
Mouse   458 DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSNLIGRYCGYEKPDD 522

  Fly   562 IKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQA 625
            ||:.|::::::||||.|:.|.||:.....:||||...:. ||:..|:||||||:|.|..||||..
Mouse   523 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAP 587

  Fly   626 NGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHY 690
            :.:.||.||||.:  ||.|||:.||.:|..||.:|.|:|::|||..:.:.|.|..|:.||.
Mouse   588 DKRRCEAACGGFL--TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN---- 646

  Fly   691 TKCNYDYLIIYSKM-RDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDV 754
            ..|.||::.:.|.: .|::|.  |.:||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.
Mouse   647 DVCKYDFVEVRSGLTADSKLH--GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 709

  Fly   755 DECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPR 819
            ||||.:|||||..|.||||||:|.||:|:.|.:|.|:|.|..|:.::|::.|.:.|||:|:.||.
Mouse   710 DECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCEHKVTSTSGTITSPNWPDKYPS 774

  Fly   820 NIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIAST 884
            ...|.|...:..|||::|||.:.::||..||.||::.::|||...:..||.:||.::|..|:|:.
Mouse   775 KKECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATG 839

  Fly   885 NEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPE 949
            |.||:...:|..:|||||:|:..:||||.:||...::..|||.::|...|...:.|:|.|.|:..
Mouse   840 NRMFLRFYSDNSVQRKGFQASHSTECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEG 904

  Fly   950 SSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDES 1013
            ..|::.|..||:|....|.|||:|:. :||...... ||:||...|..:.|..|::|::|.:|::
Mouse   905 YGVELVFQTFEVEEETDCGYDYIELF-DGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDT 968

  Fly  1014 NSLRGFAISF 1023
            .|.:||.:.:
Mouse   969 ISKKGFHLRY 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	108/200 (54%)
		CUB	388..474	CDD:214483	34/85 (40%)
		CUB	478..586	CDD:395345	58/108 (54%)
		FXa_inhibition	595..630	CDD:464251	16/35 (46%)
		CUB	634..750	CDD:395345	47/116 (41%)
		FXa_inhibition	757..792	CDD:464251	21/34 (62%)
		CUB	797..906	CDD:395345	43/108 (40%)
		CUB	910..1023	CDD:395345	39/113 (35%)
Bmp1	NP_033885.2	ZnMc_BMP1_TLD	126..325	CDD:239808	108/200 (54%)
		CUB	327..436	CDD:395345	44/133 (33%)
		CUB	440..549	CDD:395345	58/110 (53%)
		FXa_inhibition	560..592	CDD:464251	15/31 (48%)
		CUB	596..705	CDD:395345	47/116 (41%)
		FXa_inhibition	712..747	CDD:464251	21/34 (62%)
		CUB	752..861	CDD:395345	43/108 (40%)
		CUB	865..978	CDD:395345	39/113 (35%)