DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Bmp1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001346950.1	Gene:	Bmp1 / 12153	MGIID:	88176	Length:	991	Species:	Mus musculus

Alignment Length:	1050	Identity:	426/1050 - (40%)
Similarity:	613/1050 - (58%)	Gaps:	105/1050 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKE 71
            ||...:..|.:||:..|  ::..|:..| ||.| .|.:...|...::.||         |:..|:
Mouse     1 MPGVARPPLPLLSLPLL--LLLLLLPRA-GRPL-DLADYTYDLGEEDAPE---------LLNYKD 52

  Fly    72 P-------------KDD-----IYQLKTTRQHSGRRRKQSHKSQ-NKAALRLPPPFLWTDDAVDV 117
            |             ::|     :.|....||.:.||  .|.|:. |.:||
Mouse    53 PCKAAAFLGDIALDEEDLRAFQVQQAAVLRQQTARR--PSIKAAGNSSAL--------------- 100

  Fly   118 LQHSHSPTLNGQPIQ----------RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMR 172
                .....:|||.:          |.|||.|.|.||.|..||||:.|...|:|:.:|:|:||||
Mouse   101 ----GGQGTSGQPQRESRGRWRGRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMR 161

  Fly   173 HWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTI 237
            |||..||:.|:||..  ..:||.||.:.|||||::|:.|.|.|.||||:||:||||::|||||.|
Mouse   162 HWEKHTCVTFLERTD--EDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVI 224

  Fly   238 GFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLD 302
            ||.|||.|.|||:|:.|.:.||..||||||..:..:||:.....||.:||||||:|:||:..:||
Mouse   225 GFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLD 289

  Fly   303 TITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEF 367
            ||.|.....|....:|||.|||:|||.||..||||.:||.|.|.::|:..||.:   .||
Mouse   290 TIVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEY---PNG----- 346

  Fly   368 EGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKS 432
                           :.|.: :|.|||:.|.|||:||:...:.|..|..|..||:|:|||:|.|:
Mouse   347 ---------------YSAHM-HCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFWRKA 395

  Fly   433 PLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYP 496
            ||..|.||....|.|.:..||:.:.:.:.:...| :||.|.:|.:||||:|  ||.. |.|||||
Mouse   396 PLRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVG-KGFFAVYEAICGGDVK--KDNGHIQSPNYP 457

  Fly   497 MDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPN 561
            .||.|.|.|:|||...:...|.|.|||||:|:||.||||::|:|||:...|.||||:||.:.|.:
Mouse   458 DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSNLIGRYCGYEKPDD 522

  Fly   562 IKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQA 625
            ||:.|::::::||||.|:.|.||:.....:||||...:. ||:..|:||||||:|.|..||||..
Mouse   523 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAP 587

  Fly   626 NGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHY 690
            :.:.||.||||.:  ||.|||:.||.:|..||.:|.|:|::|||..:.:.|.|..|:.||.
Mouse   588 DKRRCEAACGGFL--TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN---- 646

  Fly   691 TKCNYDYLIIYSKM-RDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDV 754
            ..|.||::.:.|.: .|::|.  |.:||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.
Mouse   647 DVCKYDFVEVRSGLTADSKLH--GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 709

  Fly   755 DECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPR 819
            ||||.:|||||..|.||||||:|.||:|:.|.:|.|:|.|..|:.::|::.|.:.|||:|:.||.
Mouse   710 DECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCEHKVTSTSGTITSPNWPDKYPS 774

  Fly   820 NIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIAST 884
            ...|.|...:..|||::|||.:.::||..||.||::.::|||...:..||.:||.::|..|:|:.
Mouse   775 KKECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATG 839

  Fly   885 NEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPE 949
            |.||:...:|..:|||||:|:..:||||.:||...::..|||.::|...|...:.|:|.|.|:..
Mouse   840 NRMFLRFYSDNSVQRKGFQASHSTECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEG 904

  Fly   950 SSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDES 1013
            ..|::.|..||:|....|.|||:|:. :||...... ||:||...|..:.|..|::|::|.:|::
Mouse   905 YGVELVFQTFEVEEETDCGYDYIELF-DGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDT 968

  Fly  1014 NSLRGFAISF 1023
            .|.:||.:.:
Mouse   969 ISKKGFHLRY 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	108/200 (54%)
		Astacin	144..339	CDD:279708	105/194 (54%)
		CUB	388..474	CDD:214483	34/85 (40%)
		CUB	478..586	CDD:278839	58/108 (54%)
		FXa_inhibition	595..630	CDD:291342	16/35 (46%)
		CUB	634..750	CDD:278839	47/116 (41%)
		FXa_inhibition	757..792	CDD:291342	21/34 (62%)
		CUB	797..906	CDD:278839	43/108 (40%)
		CUB	910..1023	CDD:278839	39/113 (35%)
Bmp1	NP_001346950.1	ZnMc_BMP1_TLD	126..325	CDD:239808	108/200 (54%)
		CUB	327..436	CDD:278839	44/133 (33%)
		CUB	440..549	CDD:278839	58/110 (53%)
		FXa_inhibition	560..592	CDD:317114	15/31 (48%)
		CUB	596..705	CDD:278839	47/116 (41%)
		FXa_inhibition	712..747	CDD:317114	21/34 (62%)
		CUB	752..861	CDD:278839	43/108 (40%)
		CUB	865..978	CDD:278839	39/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1591
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1014	1.000	Inparanoid score	I286
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8692
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880