DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and cubn

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:XP_012821080.2 Gene:cubn / 100125884 XenbaseID:XB-GENE-957007 Length:3631 Species:Xenopus tropicalis


Alignment Length:899 Identity:226/899 - (25%)
Similarity:367/899 - (40%) Gaps:244/899 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 IVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPI--------- 307
            |.|..||::|                  |.:|..::.|....|:......|:.:.|         
 Frog   970 ISIPPGNLIR------------------LTFDSFNLEHGYSCSYDYLDIYDSASAIMESRIGRFC 1016

  Fly   308 --GIPPGTHLELGQRKRLSRGDIVQANL-----------------LYKCASCGRTYQQNSGHIVS 353
              .|||..         .|||:.:...|                 |....:|..:|.:.||...|
 Frog  1017 GRSIPPSI---------TSRGNTMTVLLVTDTNTAVEGFSARYTSLNATTACDASYTEASGIFSS 1072

  Fly   354 PHF--IYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDD 416
            |::  .|..|                          ..|.:.||....::::|:.....|.:|.:
 Frog  1073 PNYPNRYPNN--------------------------LECIYTITVETNKQILLNFTTFVLSTSTN 1111

  Fly   417 CTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVV---C 478
            |.:|::|||||.:..|||:.:.|.. ...||.:.::::.:.: ..:::....||.|.::..   |
 Frog  1112 CDKDHVEIRDGGYEISPLLGKFCQG-PPPVIVSHSNKLWVKF-RSDSSYSETGFSAHWDSATTGC 1174

  Fly   479 GGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGN 543
            ||.| .:......|||:||.|..:.||.|::.|.......::|:.|:||.|..|..|::.:.|||
 Frog  1175 GGTL-TSVSGGFTSPNFPMPYYHNSECYWQMMASSGSTFEIQFEHFDLESHSNCQNDYLAVYDGN 1238

  Fly   544 HSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCIN 608
            .:.|.|:.:.||.:||..|::..:.:|::|.:|:|:...||.|                      
 Frog  1239 TTHSHLLEKLCGKRLPDPIRSSGSNVYVKFRTDNSISFSGFFA---------------------- 1281

  Fly   609 TLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHA 673
                                |.:..|.||:.|.:|.|.|.|.:||:.||:::||.|.:.|...:.
 Frog  1282 --------------------TYKQTCQGVMIANRSRGILESLNYPNSYPHNQQCNWTIQATLGNT 1326

  Fly   674 VFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSD 738
            :...|:.|::||    |..|| ||:.:|.. .|.:.:.||.|||::|||...:..:.|.:.|:||
 Frog  1327 INYTFTTFNVEG----YFSCN-DYVQLYDG-PDKQARLIGTYCGNQLPPSGTTTGTSLHVVFHSD 1385

  Fly   739 RTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGS----------------------------- 774
            .|:.|.||..::.::         ||.......|||                             
 Frog  1386 DTITRPGFQMQWYVN---------GCGEELSGPFGSFTSPGFPMRYPDNRECIWHIQTSPGSSIQ 1441

  Fly   775 ---------YQCSC---------------------------RNGYTLAENGHNCTETRCKFEITT 803
                     |..:|                           .|...::..|:..|   .:|: |.
 Frog  1442 ITIWEFNIEYHSTCSYDVLEIYGGPGVSSPRLAQLCAPRPQENPLQVSSTGNTMT---VRFK-TD 1502

  Fly   804 SY-------------------------GVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFE 843
            :|                         |.:.|||||..|..|..|.|..:...|||:.|||.||:
 Frog  1503 AYVSGRGFNTTWREIPGGCGGVFQAPNGEIHSPNYPRPYEDNTECSWVIRVDFGHRVLLTFRDFD 1567

  Fly   844 VESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVS 908
            :|||..|.:|.|.::||....:..|.:.||.:.|.|:.::.|.||:.|.:|...|.:||.|.|..
 Frog  1568 IESHSSCSFDSVTVFDGPDNEADPLAVLCGTQLPAAISSTQNTMFVRLRSDGSNQHRGFSAKFTE 1632

  Fly   909 ECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQA-DPESSVKIRFLHFEIEY-SERCDYDY 971
            .||..:.|.:...|. |.|.|.:. |..|..|.|.||| :|.:.|.:.|...|||: ::.|..||
 Frog  1633 ACGSLITADSIGATI-SSPLYPAN-YPNNQNCMWIIQAQEPYNHVTLSFTDLEIEFRNDNCTLDY 1695

  Fly   972 LEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMA 1025
            :||.:.......:.||:||:..|..|.|.|:.|:::|.::.|.|.:||..:|.|
 Frog  1696 VEILDGNNPDAPVQGRYCGRTIPHPITSFSNALVVKFVSNNSTSAKGFHATFAA 1749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 19/113 (17%)
CUB 388..474 CDD:214483 22/85 (26%)
CUB 478..586 CDD:395345 37/107 (35%)
FXa_inhibition 595..630 CDD:464251 0/34 (0%)
CUB 634..750 CDD:395345 43/115 (37%)
FXa_inhibition 757..792 CDD:464251 9/99 (9%)
CUB 797..906 CDD:395345 43/133 (32%)
CUB 910..1023 CDD:395345 39/114 (34%)
cubnXP_012821080.2 cubilin_NTD 28..133 CDD:412063
EGF_CA <138..166 CDD:238011
EGF_CA 169..210 CDD:238011
EGF_CA 262..305 CDD:214542
EGF_CA 306..349 CDD:214542
EGF_3 354..388 CDD:463759
EGF_CA 398..432 CDD:238011
EGF_CA 434..470 CDD:238011
CUB 476..589 CDD:238001
CUB 594..705 CDD:238001
CUB 712..821 CDD:395345
CUB 825..935 CDD:238001
CUB 940..1052 CDD:238001 18/108 (17%)
CUB 1059..1167 CDD:238001 30/135 (22%)
CUB 1174..1283 CDD:238001 38/151 (25%)
CUB 1287..1399 CDD:238001 43/117 (37%)
CUB 1402..1515 CDD:238001 12/116 (10%)
CUB 1521..1631 CDD:238001 40/109 (37%)
CUB 1634..1749 CDD:238001 40/116 (34%)
CUB 1754..1864 CDD:238001
CUB 1868..1976 CDD:238001
CUB 1994..2104 CDD:238001
CUB 2108..2228 CDD:238001
CUB 2233..2347 CDD:238001
CUB 2352..2461 CDD:238001
CUB 2468..2580 CDD:238001
CUB 2586..2702 CDD:238001
CUB 2705..2816 CDD:238001
CUB 2821..2931 CDD:238001
CUB 2933..3041 CDD:238001
CUB 3044..3154 CDD:395345
CUB 3164..3279 CDD:238001
CUB 3284..3399 CDD:238001
CUB 3402..3514 CDD:238001
CUB 3519..3631 CDD:238001
Blue background indicates that the domain is not in the aligned region.

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