Protein Alignment tld and cubn

DIOPT Version :9

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: XP_012821080.2
• Gene: cubn / 100125884
• XenbaseID: XB-GENE-957007
• Length: 3631
• Species: Xenopus tropicalis
• Alignment Length: 899
• Identity: 226/899 - (25%)
• Similarity: 367/899 - (40%)
• Gaps: 244/899 - (27%)

  Fly   252 IVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPI--------- 307
            |.|..||::|                  |.:|..::.|....|:......|:.:.|
 Frog   970 ISIPPGNLIR------------------LTFDSFNLEHGYSCSYDYLDIYDSASAIMESRIGRFC 1016

  Fly   308 --GIPPGTHLELGQRKRLSRGDIVQANL-----------------LYKCASCGRTYQQNSGHIVS 353
              .|||..         .|||:.:...|                 |....:|..:|.:.||...|
 Frog  1017 GRSIPPSI---------TSRGNTMTVLLVTDTNTAVEGFSARYTSLNATTACDASYTEASGIFSS 1072

  Fly   354 PHF--IYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDD 416
            |::  .|..|                          ..|.:.||....::::|:.....|.:|.:
 Frog  1073 PNYPNRYPNN--------------------------LECIYTITVETNKQILLNFTTFVLSTSTN 1111

  Fly   417 CTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVV---C 478
            |.:|::|||||.:..|||:.:.|.. ...||.:.::::.:.: ..:::....||.|.::..   |
 Frog  1112 CDKDHVEIRDGGYEISPLLGKFCQG-PPPVIVSHSNKLWVKF-RSDSSYSETGFSAHWDSATTGC 1174

  Fly   479 GGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGN 543
            ||.| .:......|||:||.|..:.||.|::.|.......::|:.|:||.|..|..|::.:.|||
 Frog  1175 GGTL-TSVSGGFTSPNFPMPYYHNSECYWQMMASSGSTFEIQFEHFDLESHSNCQNDYLAVYDGN 1238

  Fly   544 HSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCIN 608
            .:.|.|:.:.||.:||..|::..:.:|::|.:|:|:...||.|
 Frog  1239 TTHSHLLEKLCGKRLPDPIRSSGSNVYVKFRTDNSISFSGFFA---------------------- 1281

  Fly   609 TLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHA 673
                                |.:..|.||:.|.:|.|.|.|.:||:.||:::||.|.:.|...:.
 Frog  1282 --------------------TYKQTCQGVMIANRSRGILESLNYPNSYPHNQQCNWTIQATLGNT 1326

  Fly   674 VFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSD 738
            :...|:.|::||    |..|| ||:.:|.. .|.:.:.||.|||::|||...:..:.|.:.|:||
 Frog  1327 INYTFTTFNVEG----YFSCN-DYVQLYDG-PDKQARLIGTYCGNQLPPSGTTTGTSLHVVFHSD 1385

  Fly   739 RTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGS----------------------------- 774
            .|:.|.||..::.::         ||.......|||
 Frog  1386 DTITRPGFQMQWYVN---------GCGEELSGPFGSFTSPGFPMRYPDNRECIWHIQTSPGSSIQ 1441

  Fly   775 ---------YQCSC---------------------------RNGYTLAENGHNCTETRCKFEITT 803
                     |..:|                           .|...::..|:..|   .:|: |.
 Frog  1442 ITIWEFNIEYHSTCSYDVLEIYGGPGVSSPRLAQLCAPRPQENPLQVSSTGNTMT---VRFK-TD 1502

  Fly   804 SY-------------------------GVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFE 843
            :|                         |.:.|||||..|..|..|.|..:...|||:.|||.||:
 Frog  1503 AYVSGRGFNTTWREIPGGCGGVFQAPNGEIHSPNYPRPYEDNTECSWVIRVDFGHRVLLTFRDFD 1567

  Fly   844 VESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVS 908
            :|||..|.:|.|.::||....:..|.:.||.:.|.|:.::.|.||:.|.:|...|.:||.|.|..
 Frog  1568 IESHSSCSFDSVTVFDGPDNEADPLAVLCGTQLPAAISSTQNTMFVRLRSDGSNQHRGFSAKFTE 1632

  Fly   909 ECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQA-DPESSVKIRFLHFEIEY-SERCDYDY 971
            .||..:.|.:...|. |.|.|.:. |..|..|.|.||| :|.:.|.:.|...|||: ::.|..||
 Frog  1633 ACGSLITADSIGATI-SSPLYPAN-YPNNQNCMWIIQAQEPYNHVTLSFTDLEIEFRNDNCTLDY 1695

  Fly   972 LEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMA 1025
            :||.:.......:.||:||:..|..|.|.|:.|:::|.::.|.|.:||..:|.|
 Frog  1696 VEILDGNNPDAPVQGRYCGRTIPHPITSFSNALVVKFVSNNSTSAKGFHATFAA 1749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	19/113 (17%)
		Astacin	144..339	CDD:279708	19/114 (17%)
		CUB	388..474	CDD:214483	22/85 (26%)
		CUB	478..586	CDD:278839	37/107 (35%)
		FXa_inhibition	595..630	CDD:291342	0/34 (0%)
		CUB	634..750	CDD:278839	43/115 (37%)
		FXa_inhibition	757..792	CDD:291342	9/99 (9%)
		CUB	797..906	CDD:278839	43/133 (32%)
		CUB	910..1023	CDD:278839	39/114 (34%)
cubn	XP_012821080.2	cubilin_NTD	28..133	CDD:412063
		EGF_CA	<138..166	CDD:238011
		EGF_CA	169..210	CDD:238011
		EGF_CA	262..305	CDD:214542
		EGF_CA	306..349	CDD:214542
		EGF_3	354..388	CDD:403986
		EGF_CA	398..432	CDD:238011
		EGF_CA	434..470	CDD:238011
		CUB	476..589	CDD:238001
		CUB	594..705	CDD:238001
		CUB	712..821	CDD:395345
		CUB	825..935	CDD:238001
		CUB	940..1052	CDD:238001	18/108 (17%)
		CUB	1059..1167	CDD:238001	30/135 (22%)
		CUB	1174..1283	CDD:238001	38/151 (25%)
		CUB	1287..1399	CDD:238001	43/117 (37%)
		CUB	1402..1515	CDD:238001	12/116 (10%)
		CUB	1521..1631	CDD:238001	40/109 (37%)
		CUB	1634..1749	CDD:238001	40/116 (34%)
		CUB	1754..1864	CDD:238001
		CUB	1868..1976	CDD:238001
		CUB	1994..2104	CDD:238001
		CUB	2108..2228	CDD:238001
		CUB	2233..2347	CDD:238001
		CUB	2352..2461	CDD:238001
		CUB	2468..2580	CDD:238001
		CUB	2586..2702	CDD:238001
		CUB	2705..2816	CDD:238001
		CUB	2821..2931	CDD:238001
		CUB	2933..3041	CDD:238001
		CUB	3044..3154	CDD:395345
		CUB	3164..3279	CDD:238001
		CUB	3284..3399	CDD:238001
		CUB	3402..3514	CDD:238001
		CUB	3519..3631	CDD:238001

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910