DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and LOC100003133

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_001342763.2	Gene:	LOC100003133 / 100003133	-ID:	-	Length:	276	Species:	Danio rerio

Alignment Length:	270	Identity:	84/270 - (31%)
Similarity:	131/270 - (48%)	Gaps:	42/270 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GRRRKQSHK---SQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERT--- 145
            |.||::|:.   .:|:.|:         |..:||..:....:::|..::....||:.|.::.
Zfish    27 GARRQRSYSEDIEENQTAM---------DRIIDVNDYQGVFSVDGTNLREGDIAVSGRSQKNCFA 82

  Fly   146 ----WDYGV-----IPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLH-ANYIYFTVKN 200
                |...|     |.|.:...:..|.....|:.|...|..||::||   |..| .:|:....|.
Zfish    83 RSCLWTKSVDGNVYIAYSLSHAYDDADVKNIKEGMELIEQDTCVRFV---PRTHQRDYLDIQPKT 144

  Fly   201 CGCCSFLGKNGNGRQPISI-GRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQE 264
             ||.|:||..| |||.||: ..:|...|:.:|||.|.:||.||.:|.||||::.|...||.:.:.
Zfish   145 -GCWSYLGARG-GRQTISLQSPDCTGSGVTVHELMHALGFVHEQSRADRDKYVTIMWSNIWKDRL 207

  Fly   265 YNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSK--SPYLDTITPIGIPPGTHLELGQRKRLSRGD 327
            .||:......:|   .|||.:|:||:.|.:||:  .|   ||.|   ....::::|||...|..|
Zfish   208 RNFEKFKTNNLD---TPYDYSSVMHFGKYAFSEDGEP---TIVP---KRNWNVKIGQRLGPSDLD 263

  Fly   328 IVQANLLYKC 337
            |::.|.||.|
Zfish   264 IMKINKLYSC 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	74/217 (34%)
		Astacin	144..339	CDD:279708	71/210 (34%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
LOC100003133	XP_001342763.2	ZnMc_hatching_enzyme	92..273	CDD:239810	68/194 (35%)
LOC100003133	XP_001342763.2	Astacin	97..274	CDD:279708	69/191 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810