DRSC/TRiP Functional Genomics Resources

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Protein Alignment tok and Cubn

DIOPT Version :10

Sequence 1:NP_476879.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_445784.3 Gene:Cubn / 80848 RGDID:68355 Length:3623 Species:Rattus norvegicus


Alignment Length:963 Identity:242/963 - (25%)
Similarity:361/963 - (37%) Gaps:290/963 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   722 KCGRTFQESSGIFASPSH---YTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDY 783
            :||.....|:||..||.|   |..|.      :|.|.:....|:.:.|:..:..:....||..||
  Rat   931 ECGEVLTASTGIIESPGHPNVYPRGV------NCTWHVVVQRGQLIRLEFSSFYLEFHYNCTNDY 989

  Fly   784 LEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSV-- 846
            |||.|  ......:||:|||.....:.:.|:.:.|.:|:...: ...||...::.:....:.:  
  Rat   990 LEIYD--TAAQTFLGRYCGKSIPPSLTSNSNSIKLIFVSDSAL-AHEGFSINYEAIDASSVCLYD 1051

  Fly   847 -DDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENH--DSCVYDYVEVRDGPGQ 908
             .|..|.|.|||:|.:|..|.||:::|||..:.|:||.|..|.:|::  ..|| |:||:|||..:
  Rat  1052 YTDNFGMLSSPNFPNNYPSNWECIYRITVGLNQQIALHFTDFILEDYFGSQCV-DFVEIRDGGYE 1115

  Fly   909 DAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTL 973
            .:||:|::||...||.:.|..|.:::||.||.::...||||.:    |...|             
  Rat  1116 TSPLVGIYCGSVLPPTIISHSNKLWLKFKSDAALTAKGFSAYW----DGSST------------- 1163

  Fly   974 GGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLN 1038
                                  .|||.:..|.|.:|||::|..|....||.|.:.|.......|.
  Rat  1164 ----------------------GCGGNLTTPTGVLTSPNYPMPYYHSSECYWRLEASHGSPFELE 1206

  Fly  1039 FTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQ 1103
            |..|.||   |..| |..|.:.|:.....|. :.|...||.:.|....|..:.:.|:..:|...|
  Rat  1207 FQDFHLE---HHPS-CSLDYLAVFDGPTTNS-RLIDKLCGDTTPAPIRSNKDVVLLKLRTDAGQQ 1266

  Fly  1104 RSGFAAVFFTDIDECAV------------------NNGGCQHECRNTIG-------------SYI 1137
            ..||...|....|...:                  .|..|....:.|.|             ||:
  Rat  1267 GRGFEINFRQRCDNVVIVNKTSGILESINYPNPYDKNQRCNWTIQATTGNTVNYTFLGFDVESYM 1331

  Fly  1138 -C----------------MCHN---------GYSMHENGH--DCKEGE-----------CKYEIS 1163
             |                .|.|         |..:|...|  ....||           |..|:|
  Rat  1332 NCSTDYVELYDGPQWMGRYCGNNMPPPGATTGSQLHVLFHTDGINSGEKGFKMQWFTHGCGGEMS 1396

  Fly  1164 APFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSV 1228
            ...|:..||.||:|||.|.:|:|:....||..|:|..::||||.|..|.||::.:|.|...:|..
  Rat  1397 GTAGSFSSPGYPNSYPHNKECIWNIRVAPGSSIQLTIHDFDVEYHTSCNYDSLEIYAGLDFNSPR 1461

  Fly  1229 LGRFCGDK---IPFPISSTSNQMYMVLKTDKNKQKNGFTASHST---ACGGYL------------ 1275
            :.:.|...   .|..:|||.|::.:..|||......||.||...   .|||.:            
  Rat  1462 IAQLCSQSPSANPMQVSSTGNELAIRFKTDSTLNGRGFNASWRAVPGGCGGIIQLSRGEIHSPNY 1526

  Fly  1276 ----RATS------QVQQFY--------------------------SHARF-------------- 1290
                ||.:      ||::.:                          ::||.              
  Rat  1527 PNNYRANTECSWIIQVERHHRVLLNITDFDLEAPDSCLTTYDGSSSTNARVASVCGRQQPPNSII 1591

  Fly  1291 --GN-------------------------------------------QDYDDGMDCEWTI-AAPD 1309
              ||                                           .:|....:|.|.| |.|.
  Rat  1592 ASGNSLFVRFRSGSSSQNRGFRAEFREECGGRIMTDSSDTIFSPLYPHNYLHNQNCSWIIEAQPP 1656

  Fly  1310 NSYVQLIFLTFDIESSENCTFDYVQVF--SDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVR 1372
            .:::.|.|..|.:::|.:||.|:|::.  :|.|      .|:.|:|||..||..|.|..::|.||
  Rat  1657 FNHITLSFTHFQLQNSTDCTRDFVEILDGNDYD------APVQGRYCGFSLPHPIISFGNALTVR 1715

  Fly  1373 FKTDGSVPMKGFSASYVAVPNS------------------GEYDHSDEDVENSYSSEMVTPFPG- 1418
            |.||.:...:||.|.|.|..:|                  .:|..:.|.|.|..||      || 
  Rat  1716 FVTDSTRSFEGFRAIYSASTSSCGGSFYTLDGIFNSPDYPADYHPNAECVWNIASS------PGN 1774

  Fly  1419 ----SLKSIYIEDTQEETDEYSDF-SGNQLVFNGQYRGRY---SLPKRYYSGK 1463
                |..|..:|::.....::.:. .||.   .|...|||   |||..|.|.:
  Rat  1775 RLQLSFLSFNLENSLNCNKDFVEIREGNA---TGHLIGRYCGNSLPGNYSSAE 1824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_476879.1 ZnMc_BMP1_TLD 520..721 CDD:239808
CUB 723..836 CDD:412131 32/115 (28%)
CUB 840..951 CDD:395345 45/115 (39%)
FXa_inhibition 958..993 CDD:464251 1/34 (3%)
CUB 997..1111 CDD:395345 35/113 (31%)
FXa_inhibition 1118..1153 CDD:464251 12/93 (13%)
CUB 1158..1267 CDD:395345 41/111 (37%)
CUB 1271..1390 CDD:238001 46/228 (20%)
CubnNP_445784.3 cubilin_NTD 38..132 CDD:412063
Interaction with AMN. /evidence=ECO:0000250|UniProtKB:O60494 39..46
EGF_CA 133..164 CDD:238011
EGF_CA 167..207 CDD:238011
EGF_CA 260..301 CDD:214542
EGF_3 306..344 CDD:463759
EGF_3 350..387 CDD:463759
EGF_CA 400..430 CDD:238011
EGF_CA 432..468 CDD:238011
CUB 474..585 CDD:238001
CUB 590..699 CDD:238001
CUB 708..815 CDD:238001
CUB 817..927 CDD:238001
CUB 932..1041 CDD:238001 32/117 (27%)
CUB 1048..1157 CDD:395345 44/109 (40%)
CUB 1165..1275 CDD:238001 35/114 (31%)
CUB 1278..1388 CDD:238001 15/109 (14%)
CUB 1391..1505 CDD:238001 42/113 (37%)
CUB 1510..1617 CDD:238001 11/106 (10%)
CUB 1620..1733 CDD:238001 35/118 (30%)
CUB 1738..1847 CDD:238001 22/96 (23%)
CUB 1852..1962 CDD:238001
CUB 1978..2088 CDD:238001
CUB 2092..2212 CDD:238001
CUB 2217..2333 CDD:238001
CUB 2336..2447 CDD:238001
CUB 2452..2564 CDD:238001
CUB 2570..2686 CDD:238001
CUB 2689..2800 CDD:238001
CUB 2805..2918 CDD:238001
CUB 2920..3034 CDD:238001
CUB 3037..3148 CDD:238001
CUB 3157..3273 CDD:238001
CUB 3278..3392 CDD:238001
CUB 3395..3506 CDD:238001
CUB 3511..3623 CDD:238001
Blue background indicates that the domain is not in the aligned region.

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