DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and pcolceb

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001122259.1	Gene:	pcolceb / 794872	ZFINID:	ZDB-GENE-080722-44	Length:	538	Species:	Danio rerio

Alignment Length:	274	Identity:	86/274 - (31%)
Similarity:	126/274 - (45%)	Gaps:	44/274 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   839 VCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVR 903
            :|||.|..|.  |.:.|..:|..|..|.:|.|.|||||.:.|.|:|:.|::|...:|.||||:|.
Zfish    34 LCGGHLVTDS--GFVASEGFPSHYKANSKCTWYITVPEGHVVMLQFRIFDLEADPTCRYDYVDVY 96

  Fly   904 DGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHE 968
            :|.......:|.|||...|..:.|:.|:|.::..||:|....||.|.|.
Zfish    97 NGHSYTVQKLGRFCGTFRPGALISTSNTMMLEMASDSSTGGRGFLAYFS---------------- 145

  Fly   969 CINTLGGYECSCRIGFELHSDKKHCED--ACGGVIEYPNGTITSPSFPEM-YPLLKECIWEIVAP 1030
                 ||              |.|.::  .|||.:..|.|::.:|::||. ||....|.|.|...
Zfish   146 -----GG--------------KPHVDEHQFCGGRLTKPQGSVKTPNWPESDYPAGISCSWHISVE 191

  Fly  1031 PKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLE 1095
            ....|.:.|...|||...:    |.||.|.:::....:..:|||.|||.::|....:..|.|.:.
Zfish   192 SNMVIEVKFEKLDLELDTY----CRYDYVALFNGGETDDSRRIGKFCGDTVPDAVVTNGNELLVH 252

  Fly  1096 FHSDKSIQRSGFAA 1109
            |.||.|:..:||.|
Zfish   253 FVSDLSVTAAGFMA 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		Astacin	527..721	CDD:279708
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839	43/110 (39%)
		FXa_inhibition	958..993	CDD:291342	3/34 (9%)
		CUB	997..1111	CDD:278839	38/114 (33%)
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
pcolceb	NP_001122259.1	CUB	35..145	CDD:238001	43/111 (39%)
		CUB	157..270	CDD:238001	38/114 (33%)
		Hc1	<334..398	CDD:284776
		NTR_like	416..538	CDD:295338
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910