DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and TLL2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_036597.1	Gene:	TLL2 / 7093	HGNCID:	11844	Length:	1015	Species:	Homo sapiens

Alignment Length:	938	Identity:	477/938 - (50%)
Similarity:	630/938 - (67%)	Gaps:	37/938 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 QSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSKD---EEPLRH--------------RVAR 519
            :.|.....||..|..:...........||....|..||   ...|.|              ||.|
Human    85 KQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRR 149

  Fly   520 AVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSC 584
            |.|::.||||..|||||.|.|||:|..:|:||.||||||..||:.|:||..|  .::|||:.|:|
Human   150 ATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDE--ESFIVFSYRTC 212

  Fly   585 GCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYN 649
            ||||:||:||.||||||||:||||||||.||||||||||||||||||::||.|...||..||:||
Human   213 GCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYN 277

  Fly   650 FNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQA 714
            |..:...||.|||..||:||||||||||||:|.:||||||.:.....||.||||:||||||||||
Human   278 FLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQA 342

  Fly   715 NLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNC 779
            ..|||||.||.|.|:::|.|::|. :..|..|  ..||.|||:.|.||::.|...:|::|||..|
Human   343 RKLYKCPACGETLQDTTGNFSAPG-FPNGYPS--YSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404

  Fly   780 ETDYLEIRDGYFEKSPLIGRFCG-KVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGE 843
            ..||:|:||||:.|:||:||||| |:.:.::.|: ||:.:.:.::..|.| :||.|.::..|||:
Human   405 WYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTD-SRLWVEFRSSSNILG-KGFFAAYEATCGGD 467

  Fly   844 LSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQ 908
            ::.|  .|:::|||||.||.|:|||||:|||.|.:.|.|.||:||:|.||||.|||:||||||.:
Human   468 MNKD--AGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTE 530

  Fly   909 DAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNH-GCEHECINT 972
            ::.|||.||||:.|.::|||.|.:::|||||.|:.||||:|.|.||||||...:| ||||.|:||
Human   531 ESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNT 595

  Fly   973 LGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISL 1037
            ||.|:|:|..|:||.:|||.||.||||.|...|||||||.:|:.||..|.|:|::|||.::||||
Human   596 LGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISL 660

  Fly  1038 NFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSI 1102
            .|..|:|||    ...|.||.|.|.|.|..: .|..|.||||..|...||:||.:|:||.||.::
Human   661 QFEVFELEG----NDVCKYDFVEVRSGLSPD-AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTV 720

  Fly  1103 QRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFG 1167
            .:.||.|.||:|.||||.:||||||||.||.|||:|.|.|||.:|||||||||..|.::||:..|
Human   721 SKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEG 785

  Fly  1168 TIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRF 1232
            |:.|||:||.||...:|.|:..:|.|||:||.||||::|.||||.||::.:|||....:.:||||
Human   786 TLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRF 850

  Fly  1233 CGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDD 1297
            ||.|.|.|..::.:.|::...:|.:.|:.||.|.|||.|||.|:|..|.::.||||:||:.:|..
Human   851 CGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPS 915

  Fly  1298 GMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDI 1362
            ...|:|.|.|.|...|:|.|.||::|...:|.:||::.:    |.|....|..|::||:...::|
Human   916 EARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAY----DGYDSSAPRLGRFCGSGPLEEI 976

  Fly  1363 NSMTHSLLVRFKTDGSVPMKGFSASYVA 1390
            .|...||::||:||.::..|||.|.|.:
Human   977 YSAGDSLMIRFRTDDTINKKGFHARYTS 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	133/200 (67%)
		Astacin	527..721	CDD:279708	130/193 (67%)
		CUB	723..836	CDD:294042	47/113 (42%)
		CUB	840..951	CDD:278839	65/110 (59%)
		FXa_inhibition	958..993	CDD:291342	20/35 (57%)
		CUB	997..1111	CDD:278839	55/113 (49%)
		FXa_inhibition	1118..1153	CDD:291342	25/34 (74%)
		CUB	1158..1267	CDD:278839	49/108 (45%)
		CUB	1271..1390	CDD:238001	46/118 (39%)
TLL2	NP_036597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..130		8/41 (20%)
		ZnMc_BMP1_TLD	150..349	CDD:239808	133/200 (67%)
		Astacin	157..350	CDD:279708	131/194 (68%)
		CUB	351..460	CDD:278839	47/113 (42%)
		CUB	464..573	CDD:278839	65/110 (59%)
		FXa_inhibition	584..616	CDD:291342	19/31 (61%)
		CUB	620..729	CDD:278839	55/113 (49%)
		FXa_inhibition	736..771	CDD:291342	25/34 (74%)
		CUB	776..885	CDD:278839	49/108 (45%)
		CUB	889..1002	CDD:278839	45/116 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1016	1.000	Inparanoid score	I282
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8453
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900