DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and TLL1

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_036596.3	Gene:	TLL1 / 7092	HGNCID:	11843	Length:	1013	Species:	Homo sapiens

Alignment Length:	901	Identity:	465/901 - (51%)
Similarity:	627/901 - (69%)	Gaps:	39/901 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 TSKDEEPL-------RHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCI 563
            |.|.:.||       ::||.||.|::.||||..|||||.|.|||:|..:|:||.||||||..||:
Human   127 TVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCV 191

  Fly   564 KFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTR 628
            .|:||..|  .:|||||.|.|||||:||:|||||||||||:|||||||||||||||:||||||||
Human   192 TFIERSDE--ESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTR 254

  Fly   629 PDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMK 693
            |||:.||.|...||..||:|||..:.|.||:|||..||:||||||||||||:|.:||||||....
Human   255 PDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDD 319

  Fly   694 GRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS------HYTAGALSNETEHC 752
            ...||.||||.|||:||||||..||:||.||.|.|||:|..:||.      .||         ||
Human   320 NGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYT---------HC 375

  Fly   753 EWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRML 817
            .||::.|.||::.|....|:::||:.|..||:|:||||:.||||:|||||....||:.:..|||.
Human   376 IWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMW 440

  Fly   818 LTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVAL 882
            :.:.::....| :||.|.::.:||||:..::  |:::|||||.||.|.|||||||||.|||.|.|
Human   441 IEFRSSSNWVG-KGFAAVYEAICGGEIRKNE--GQIQSPNYPDDYRPMKECVWKITVSESYHVGL 502

  Fly   883 KFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGF 947
            .|||||:|.||:|.|||:|||||..:::||||.||||..|.:::|:.|::::|||||.:|.||||
Human   503 TFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGF 567

  Fly   948 SAVFMKEVDEC-ETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSP 1011
            :|.|.||.||| :....|||..|:||||.|:|:|..|:||..|::.||.||||::...|||||:|
Human   568 AANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTP 632

  Fly  1012 SFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKL-GENRLKRIGT 1075
            .:|:.||..|.|:|::|||.::|||:.|..|:|||    ...|.||.|.::|.| .|::|.  |.
Human   633 GWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEG----NEVCKYDYVEIWSGLSSESKLH--GK 691

  Fly  1076 FCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMC 1140
            |||:.:|...||:.|.:|:||.||.::.:.||.|.||:|.|||:.:||||||||.||:|||:|.|
Human   692 FCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQC 756

  Fly  1141 HNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDV 1205
            .||:.:|:|.|||||.||:.:|.:|.|.|.|||:||.||...:|.|....||||||||.|:||::
Human   757 RNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEI 821

  Fly  1206 ESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTA 1270
            |.||||.||::.|:|||:|.|.:|||.||:|||.|:.:|.|:|::...:|.:.|:.||.|:|||.
Human   822 EQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE 886

  Fly  1271 CGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQV 1335
            |||.|:|.|:.:..||||:||:.:|...:||||.:.:...|.::|.|.||::|...:|.:|||::
Human   887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEL 951

  Fly  1336 FSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAV 1391
            |..:|..    ....|::||:..|::|.|:..|:|:.|.||.::..|||...|.::
Human   952 FDGLDST----AVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	135/200 (68%)
		Astacin	527..721	CDD:279708	132/193 (68%)
		CUB	723..836	CDD:294042	48/118 (41%)
		CUB	840..951	CDD:278839	66/110 (60%)
		FXa_inhibition	958..993	CDD:291342	16/35 (46%)
		CUB	997..1111	CDD:278839	50/114 (44%)
		FXa_inhibition	1118..1153	CDD:291342	21/34 (62%)
		CUB	1158..1267	CDD:278839	55/108 (51%)
		CUB	1271..1390	CDD:238001	44/118 (37%)
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808	135/200 (68%)
		Astacin	155..348	CDD:279708	133/194 (69%)
		CUB	349..458	CDD:278839	48/118 (41%)
		CUB	462..571	CDD:278839	66/110 (60%)
		FXa_inhibition	582..614	CDD:291342	15/31 (48%)
		CUB	618..727	CDD:278839	50/114 (44%)
		FXa_inhibition	734..769	CDD:291342	21/34 (62%)
		CUB	774..883	CDD:278839	55/108 (51%)
		CUB	887..1000	CDD:278839	43/116 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49202
Inparanoid	1	1.050	1016	1.000	Inparanoid score	I282
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8453
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	LDO	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.900