DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and PCOLCE2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001121112.1	Gene:	PCOLCE2 / 684050	RGDID:	1595195	Length:	414	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	100/320 - (31%)
Similarity:	145/320 - (45%)	Gaps:	61/320 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRD 904
            |||.|:.:.  |.:.|..:|..|.||.:|.|||||||...|.|.|:..::||.:.|.||:|:|.:
  Rat    32 CGGILTGES--GFIGSEGFPGMYPPNSKCTWKITVPEGKVVVLNFRFIDLENDNLCRYDFVDVYN 94

  Fly   905 GPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHEC 969
            |.. :...||.|||...|.::.:|||.|.|:.:||.:...:||.|.|.....:.:...:
  Rat    95 GHA-NGQRIGRFCGTFRPGSLVASGNKMMVQMISDANTAGSGFMATFSAAAPDGKGDRY------ 152

  Fly   970 INTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEM-YPLLKECIWEIVAPPKH 1033
                                       |||.:|.|:|:..:|::|:. ||:...|:|.|:||...
  Rat   153 ---------------------------CGGRLEKPSGSFKTPNWPDRDYPVGVTCVWHIIAPKNQ 190

  Fly  1034 RISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHS 1098
            .|.|.|..||:|    :.:.|.||.|.|::....|..||||.:||.|.|....||.|.|.::|.|
  Rat   191 LIELKFEKFDVE----RDNYCRYDYVAVFNGGEVNDAKRIGKYCGDSPPVPIVSEKNELLIQFLS 251

  Fly  1099 DKSIQRSGFAAVF------FTDIDECAVNN------------GGCQHECR--NTIGSYIC 1138
            |.|:...||...:      |.......|..            ..||.:||  .|:.|..|
  Rat   252 DLSLTADGFIGHYKFRPKKFPTTTATPVTTTFPVTIGLKPTVALCQQKCRRMGTLESNYC 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		Astacin	527..721	CDD:279708
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839	45/110 (41%)
		FXa_inhibition	958..993	CDD:291342	0/34 (0%)
		CUB	997..1111	CDD:278839	45/114 (39%)
		FXa_inhibition	1118..1153	CDD:291342	8/35 (23%)
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
PCOLCE2	NP_001121112.1	CUB	32..142	CDD:238001	46/112 (41%)
		CUB	153..264	CDD:278839	45/114 (39%)
		NTR_PCOLCE	291..414	CDD:239631	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000