DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and Cubn

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001074553.1	Gene:	Cubn / 65969	MGIID:	1931256	Length:	3623	Species:	Mus musculus

Alignment Length:	753	Identity:	221/753 - (29%)
Similarity:	323/753 - (42%)	Gaps:	159/753 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   707 SQGDIAQANLLYKCPKCGRTFQ--------------ESSGIFAS---PSHYTAGALSNETEHCEW 754
            |..||....|.....:.||.|:              ::|||..|   |:.|      ::.:.|.|
Mouse  1250 SSKDIVLLKLRTDAGQQGRGFEINYRQTCDNVVIVNKTSGILESINYPNPY------DKDQRCNW 1308

  Fly   755 RITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLT 819
            .|.||.|..|.......::....||.|||||:.||    ...|||:||:.......|..|::::.
Mouse  1309 TIQATTGNTVNYTFLEFDVENYVNCSTDYLELYDG----PQRIGRYCGENIPPPGATTGSKLIVV 1369

  Fly   820 YVNTHRIEGFRGFKAEFDV-VCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALK 883
            :.......|.:|||..:.: .||||:|  ..:|...||.||..|..||||:|.|.|.....:.|.
Mouse  1370 FHTDGVDSGEKGFKMHWFIHGCGGEMS--GTMGSFSSPGYPNSYPHNKECIWNIRVAPGNSIQLT 1432

  Fly   884 FQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKP---PPNMKSSGNSMYVKFVSDTSVQKA 945
            ...|:||.|.||.||.:|:..|....:|.|...|...|   |..:.|:.|.:.::|.:|:|:...
Mouse  1433 IHDFDVEYHASCKYDTLEIYTGLDFHSPRIAQLCSRSPSANPMQISSTDNELAIRFKTDSSLNGR 1497

  Fly   946 GFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITS 1010
            ||:|.:..                  ..||                     |||:.:...|.|.|
Mouse  1498 GFNASWRA------------------VPGG---------------------CGGIFQVSRGEIHS 1523

  Fly  1011 PSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGT 1075
            |::|..|....||.|.|.....||:.||.|.||||.|         ||..:......:...|:.|
Mouse  1524 PNYPNNYRANTECSWIIQVEKYHRVLLNITDFDLEAT---------DSCLMTYDGSSSANTRVAT 1579

  Fly  1076 FCGSSIPPTA-TSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICM 1139
            .||...||.: ||..|:|.:.|.|..|.|..||.|.|              :.||    |::|
Mouse  1580 VCGRQQPPNSITSSGNSLFVRFQSGSSSQSRGFRAQF--------------RQEC----GAHI-- 1624

  Fly  1140 CHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHF-ITTPGHRIKLIFNEF 1203
                                  |:....:|.||.||.:||.|.:|.|.. ...|.:.|.|.|..|
Mouse  1625 ----------------------ITDSSDSISSPLYPANYPNNQNCTWIIEAQPPFNHIALSFTHF 1667

  Fly  1204 DVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHS 1268
            .::|..:||.|.|.:.||....:.|.||:||..:|.||.|..|.:.:...:|.....:||.|.:|
Mouse  1668 HLQSSTDCTRDFVEILDGRDSDAPVQGRYCGTSLPHPIISFGNALTVRFVSDSVYGFDGFHAIYS 1732

  Fly  1269 ---TACGGYLRATSQVQQFYSHARFGN-----QDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESS 1325
               :||||         .||:.....|     :||....:|.|.||:...:::||.||:|.:|:|
Mouse  1733 ASTSACGG---------TFYTGDGIFNSPGYPEDYHSNTECVWNIASSPGNHLQLSFLSFQLENS 1788

  Fly  1326 ENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMT-HSLLVRFKTDGSVPMKGFSASYV 1389
            .||..|:|::...     ...|.:.|:||||.||.:.:|:. |:|.|||.:|||....||.|.:.
Mouse  1789 LNCNKDFVEIREG-----NATGHLMGRYCGNSLPGNYSSIEGHNLWVRFVSDGSGTGMGFQARFK 1848

  Fly  1390 AVPNSGEYDHSDEDVENSYSSEMVTPF-PGS--LKSIY 1424
            .:       ..::::..:: .::.||| ||:  |.|.|
Mouse  1849 NI-------FGNDNIVGTH-GKIATPFWPGNYPLNSNY 1878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	4/13 (31%)
		Astacin	527..721	CDD:279708	4/13 (31%)
		CUB	723..836	CDD:294042	36/129 (28%)
		CUB	840..951	CDD:278839	42/113 (37%)
		FXa_inhibition	958..993	CDD:291342	2/34 (6%)
		CUB	997..1111	CDD:278839	42/114 (37%)
		FXa_inhibition	1118..1153	CDD:291342	4/34 (12%)
		CUB	1158..1267	CDD:278839	37/109 (34%)
		CUB	1271..1390	CDD:238001	43/124 (35%)
Cubn	NP_001074553.1	Interaction with AMN. /evidence=ECO:0000250\|UniProtKB:O60494	39..46
		EGF_CA	133..164	CDD:238011
		EGF_CA	167..207	CDD:238011
		EGF_CA	260..301	CDD:214542
		EGF_3	306..344	CDD:289699
		EGF_3	350..387	CDD:289699
		EGF_CA	400..430	CDD:238011
		EGF_CA	432..468	CDD:238011
		CUB	474..585	CDD:238001
		CUB	590..699	CDD:238001
		CUB	708..815	CDD:238001
		CUB	817..927	CDD:238001
		CUB	932..1041	CDD:238001
		CUB	1052..1158	CDD:238001
		CUB	1165..1275	CDD:238001	7/24 (29%)
		CUB	1278..1388	CDD:238001	33/119 (28%)
		CUB	1391..1505	CDD:238001	42/115 (37%)
		CUB	1510..1599	CDD:238001	35/97 (36%)
		CUB	1620..1733	CDD:238001	40/140 (29%)
		CUB	1738..1847	CDD:238001	43/122 (35%)
		CUB	1859..1962	CDD:238001	8/21 (38%)
		CUB	1978..2089	CDD:238001
		CUB	2092..2212	CDD:238001
		CUB	2217..2333	CDD:238001
		CUB	2336..2447	CDD:238001
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3623	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840