DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and BMP1

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens

Alignment Length:	943	Identity:	456/943 - (48%)
Similarity:	621/943 - (65%)	Gaps:	51/943 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 QQQHHRRRGQSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPL---------RHRVA 518
            ||....||..:....:..:.||...:...|              |.:.:|.         |.|..
Human    69 QQAVDLRRHTARKSSIKAAVPGNTSTPSCQ--------------STNGQPQRGACGRWRGRSRSR 119

  Fly   519 RAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRS 583
            ||.|::.||:|..||||:.|.|||:|..:|:|:.||||||..||:.|:||..|  .:|||||.|.
Human   120 RAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE--DSYIVFTYRP 182

  Fly   584 CGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDY 648
            |||||:||:||.||||||||:|||||||||||||||||||||||||||::||.|...||..||:|
Human   183 CGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEY 247

  Fly   649 NFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILP-IEMKGRKRPEIGQRLRLSQGDIA 712
            ||..:.|.||:|||..||:||||||||||||:|.:||||:| .|:.|.| |.||||.|||:||||
Human   248 NFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVK-PPIGQRTRLSKGDIA 311

  Fly   713 QANLLYKCPKCGRTFQESSGIFASPSH---YTAGALSNETEHCEWRITATYGERVELKLENMNIF 774
            ||..|||||.||.|.|:|:|.|:||.:   |:|..      ||.|||:.|.||::.|...:::::
Human   312 QARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHM------HCVWRISVTPGEKIILNFTSLDLY 370

  Fly   775 KSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVV 839
            :|..|..||:|:|||::.|:||.|||||....|.|.:..||:.:.:.::....| :||.|.::.:
Human   371 RSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVG-KGFFAVYEAI 434

  Fly   840 CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRD 904
            |||::..|  .|.::|||||.||.|:|.|:|:|.|.|.:.|.|.|||||:|.||||.|||:||||
Human   435 CGGDVKKD--YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRD 497

  Fly   905 GPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNH-GCEHE 968
            |..:.:.|||.:|||:.|.::||:.:.:::|||||.|:.||||:..|.||||||...|. |||..
Human   498 GHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQR 562

  Fly   969 CINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKH 1033
            |:||||.|:|||..|:||..||:.||.||||.:...||:||||.:|:.||..|.|||::|||.::
Human   563 CLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQY 627

  Fly  1034 RISLNFTHFDLEGTAHQQSDCGYDSVTVYSKL-GENRLKRIGTFCGSSIPPTATSESNALRLEFH 1097
            ||||.|..|:.||    ...|.||.|.|.|.| .:::|.  |.||||..|...||:.|.:|:||.
Human   628 RISLQFDFFETEG----NDVCKYDFVEVRSGLTADSKLH--GKFCGSEKPEVITSQYNNMRVEFK 686

  Fly  1098 SDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEI 1162
            ||.::.:.||.|.||:|.|||:.:|||||.:|.||.|||.|.|.:|:.:|:|.|||||..|.:::
Human   687 SDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKV 751

  Fly  1163 SAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSS 1227
            ::..|||.|||:||.||...:|.|...:|||||:||.|.|.|:||..||.||::.|:||....:.
Human   752 TSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAP 816

  Fly  1228 VLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGN 1292
            |||||||.|.|.|:.:|.::|::...:|.:.|:.||.|||:|.|||.:||..:.:..||||:||:
Human   817 VLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGD 881

  Fly  1293 QDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNV 1357
            .:|..|:||||.|.|.:...|:|:|.||::|...:|.:||:::|    |.|....|..|:|||:.
Human   882 NNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELF----DGYDSTAPRLGRYCGSG 942

  Fly  1358 LPQDINSMTHSLLVRFKTDGSVPMKGFSASYVA 1390
            .|:::.|...|:||:|.:|.::..|||...|.:
Human   943 PPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTS 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	134/201 (67%)
		Astacin	527..721	CDD:279708	131/194 (68%)
		CUB	723..836	CDD:294042	44/115 (38%)
		CUB	840..951	CDD:278839	58/110 (53%)
		FXa_inhibition	958..993	CDD:291342	19/35 (54%)
		CUB	997..1111	CDD:278839	52/114 (46%)
		FXa_inhibition	1118..1153	CDD:291342	18/34 (53%)
		CUB	1158..1267	CDD:278839	49/108 (45%)
		CUB	1271..1390	CDD:238001	47/118 (40%)
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	134/201 (67%)
		Astacin	128..321	CDD:279708	132/195 (68%)
		CUB	322..431	CDD:278839	44/115 (38%)
		CUB	435..544	CDD:278839	58/110 (53%)
		FXa_inhibition	555..587	CDD:291342	18/31 (58%)
		CUB	591..700	CDD:278839	52/114 (46%)
		FXa_inhibition	707..742	CDD:291342	18/34 (53%)
		CUB	747..856	CDD:278839	49/108 (45%)
		CUB	860..973	CDD:278839	46/116 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1016	1.000	Inparanoid score	I282
Isobase	1	0.950	-	0	Normalized mean entropy	S3510
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8453
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.850