DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	844	Identity:	162/844 - (19%)
Similarity:	287/844 - (34%)	Gaps:	283/844 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 IMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRL 706
            |..|..||.|:.....||...:|:|...::        ...:|.:.|..|.|..:..:..:..|.
Human    64 ITSGVTYNPNLQDKLSVDFKVLAFDLQQMI--------DEIFLSSNLKNEYKNSRVLQFDKNWRQ 120

  Fly   707 SQGDIAQANLLYKC--PKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLE 769
            ::.::.....||..  ....:.:|::..|......:.|..:|:|            ..:.|| ::
Human   121 AENEVESTVSLYSLYGSWIHQKYQKNGSIIVVFDLFFAQWVSDE------------NVKEEL-IQ 172

  Fly   770 NMNIFKSNNCETDYLEIR--------DGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTH-- 824
            .:...||:...|.::::.        :.:...||              .|.|.::..|   :|
Human   173 GLEANKSSQLVTFHIDLNSVDILASLENFSTVSP--------------ATTSDKLTTT---SHLA 220

  Fly   825 -----RIEGFRG----------FKAEFDVVCGGELSVDD---------------------AVGRL 853
                 .||...|          .||  |:.|.||::..|                     :.|..
Human   221 TPGNVSIECLPGSSPCTDALTCIKA--DLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSF 283

  Fly   854 ESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCG 918
            ::.:||.....:..|.|.|.|.:...:.|.|..|     ::...|.:::.:|.| .:.::.....
Human   284 QATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDF-----NTYYTDILDIYEGVG-SSKILRASIW 342

  Fly   919 YKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINT--LGGYE---C 978
            ...|..::...|.:               :|.|:.|.||.:.......:...|:  |..||   |
Human   343 ETNPGTIRIFSNQV---------------TATFLIESDESDYVGFNATYTAFNSSELNNYEKINC 392

  Fly   979 SCRIGF-----ELHSDKK------------------HC-EDACGGVIEYPN---------GTITS 1010
            :...||     :|:.|.:                  |. .:|.|..|..|.         |.::.
Human   393 NFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSL 457

  Fly  1011 PSFPEMYPLLKECIWEIVAPPKHRISLNFTH-FDLEGTAHQQ-----SDCGYDSVTVYSKLGENR 1069
            |..|.:.|......:.:.....|::|:|.:: .::|.|..|:     .:..|..||:
Human   458 PLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTL-------- 514

  Fly  1070 LKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIG 1134
                             :|:...::.|::.|:...|..|      :|:.::..|.|
Human   515 -----------------NETVKFKVAFNAFKNKILSDIA------LDDISLTYGIC--------- 547

  Fly  1135 SYICMCHNGYSMH-----------ENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHF 1188
                   || |::           |...||..   .:|:..|..|..|.|:|:|||..|.|||..
Human   548 -------NG-SLYPEPTLVPTPPPELPTDCGG---PFELWEPNTTFSSTNFPNSYPNLAFCVWIL 601

  Fly  1189 ITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPIS---STSNQMYM 1250
            ....|..|:|.|.|||:|:    ..|.|.:.|||...|.:|..:.|   |.|:.   ||:|:|.:
Human   602 NAQKGKNIQLHFQEFDLEN----INDVVEIRDGEEADSLLLAVYTG---PGPVKDVFSTTNRMTV 659

  Fly  1251 VLKTDKNKQKNGFTASHSTA---------------------------CGGYLRATSQVQQFYSHA 1288
            :|.|:....:.||.|:.:|.                           |.|:|..
Human   660 LLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHC----------- 713

  Fly  1289 RFGNQDYDDGMDCE--WTIAAPDNSYVQLIFLTFDIES------SENCTFDYVQVFSDIDDVYG 1344
                :|..|..||.  :.....:|..|:     |.|:|      :||.|   .|:.:|:..:.|
Human   714 ----EDGSDEADCVRFFNGTTNNNGLVR-----FRIQSIWHTACAENWT---TQISNDVCQLLG 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	16/80 (20%)
		Astacin	527..721	CDD:279708	16/80 (20%)
		CUB	723..836	CDD:294042	21/137 (15%)
		CUB	840..951	CDD:278839	20/131 (15%)
		FXa_inhibition	958..993	CDD:291342	9/62 (15%)
		CUB	997..1111	CDD:278839	21/128 (16%)
		FXa_inhibition	1118..1153	CDD:291342	6/45 (13%)
		CUB	1158..1267	CDD:278839	40/111 (36%)
		CUB	1271..1390	CDD:238001	18/82 (22%)
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554	26/151 (17%)
		LDLa	229..263	CDD:238060	8/35 (23%)
		CUB	270..376	CDD:278839	20/126 (16%)
		MAM	387..547	CDD:214533	32/190 (17%)
		MAM	392..547	CDD:99706	30/185 (16%)
		CUB	569..676	CDD:278839	41/116 (35%)
		LDLa	688..722	CDD:238060	5/48 (10%)
		SR	723..816	CDD:214555	11/51 (22%)
		Tryp_SPc	829..1059	CDD:214473
		Tryp_SPc	830..1061	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910