DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and bmp1b

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	XP_005155463.1	Gene:	bmp1b / 559877	ZFINID:	ZDB-GENE-060818-2	Length:	970	Species:	Danio rerio

Alignment Length:	942	Identity:	465/942 - (49%)
Similarity:	613/942 - (65%)	Gaps:	49/942 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 KKHRRQQQHHRRRGQSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPLRH----RVA 518
            |.|......:...|.|....||.|....|                    :|||..|.:    |..
Zfish    58 KAHYMHATENESSGSSKPDSVNRSSANRN--------------------AKDEPVLANQSILRRR 102

  Fly   519 RAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRS 583
            ||.||:.||:|..|:|||.|.|||:|..:|:||.||||||..||:.||||  .:..:|||||:|.
Zfish   103 RAATARPERVWPNGIIPYIISGNFTGSQRAIFKQAMRHWEKHTCVTFVER--SVEESYIVFTLRP 165

  Fly   584 CGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDY 648
            ||||||||:||.||||||||:|||||||||||||||:|||||||||||::||.|...||..||:|
Zfish   166 CGCCSFVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDEHVDIFRENIQPGQEY 230

  Fly   649 NFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQ 713
            ||..:.||:|||||..||:||||||||||||:|.||||:||.......||.||||.|||:|||||
Zfish   231 NFIKMEPDDVDSLGEVYDFDSIMHYARNTFSRGIYLDTMLPKYDVDGVRPPIGQRTRLSKGDIAQ 295

  Fly   714 ANLLYKCPKCGRTFQESSGIFAS---PSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFK 775
            |..||:||:||.:.|:|:|.|:|   |:.|.|..      ||.|||:.|.||::.|...:|::::
Zfish   296 ARKLYRCPRCGESLQDSAGNFSSPGFPNGYAAYL------HCIWRISVTPGEKIVLNFTSMDLYR 354

  Fly   776 SNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVC 840
            ||.|..||:|:||||...:||.||.||....|.|.:..|.:.:.:.:|....| :||.|.::.:|
Zfish   355 SNLCWYDYVEVRDGYGRSAPLKGRICGDQLPEAIVSTDSELWIEFRSTSNWVG-KGFSAVYEAIC 418

  Fly   841 GGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDG 905
            |||:..|.  |::||||||.||.|||.|:|||.|||.:.|.|.|||||:|.||:|.|||:|||||
Zfish   419 GGEVRRDS--GQIESPNYPDDYRPNKACIWKIVVPEGFHVGLVFQSFEIEKHDNCAYDYLEVRDG 481

  Fly   906 PGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDEC-ETQNHGCEHEC 969
            ..:.:||:|.||||:.|.:.|||.|.:::|||||.||.||||:|.|.||:||| ...|..||..|
Zfish   482 DSESSPLLGRFCGYEKPDDFKSSSNQLWMKFVSDGSVNKAGFAANFFKEIDECSRPDNAHCEQRC 546

  Fly   970 INTLGGYECSCRIGFELHSDKKHC-EDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKH 1033
            |||||.:.|:|..||||..|::.| ..||||.|...||:.|||.:|:.||..|.|:|:::||.::
Zfish   547 INTLGSFHCACDPGFELAPDRRSCAAAACGGFISKLNGSFTSPGWPQEYPPNKNCVWQLIAPVQY 611

  Fly  1034 RISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHS 1098
            ||:|.|..|::||    ...|.||.|.|:|.|..:. |..|.|||:..|...||:.|::.:||.|
Zfish   612 RITLLFDAFEMEG----NDVCKYDYVEVHSGLSADG-KLHGKFCGTEKPEAITSQLNSMSVEFKS 671

  Fly  1099 DKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEIS 1163
            |.::.:.||.|.||:|:|||:..||||||||.||.|||.|.|.:|:.:|.|.|||||..|...|:
Zfish   672 DNTVSKRGFKAQFFSDMDECSRENGGCQHECVNTFGSYSCQCRSGFVLHSNKHDCKEVGCDQAIT 736

  Fly  1164 APFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSV 1228
            :..|.|.|||:||.||....|.|...|||||||||.|.|.|:|:||||.||::.:|||::..::.
Zfish   737 SVSGLITSPNWPDKYPSKKACTWTLSTTPGHRIKLAFEEIDMEAHQECAYDHLEIYDGQNGRATS 801

  Fly  1229 LGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQ 1293
            :|||||.|.|.|:.|:||.|::...:|.:.||.||.||||..|||.|:|..:.:..||||:||:.
Zfish   802 VGRFCGSKKPSPVISSSNTMFLRFFSDNSVQKRGFKASHSAECGGSLKAEIKTKDLYSHAQFGDN 866

  Fly  1294 DYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVL 1358
            :|....||:|.|:|.....|:|||.||:||...:|.:|||::| |..||   ..|..|:|||:..
Zfish   867 NYPGASDCQWVISAEKGYGVELIFHTFEIEEEADCGYDYVELF-DGGDV---KAPRLGRYCGSGP 927

  Fly  1359 PQDINSMTHSLLVRFKTDGSVPMKGFSASYVA 1390
            |::|.|...:::::|.:|.::..|||...|.:
Zfish   928 PEEIYSAGDAIVIKFHSDDTINKKGFHVRYTS 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	135/200 (68%)
		Astacin	527..721	CDD:279708	131/193 (68%)
		CUB	723..836	CDD:294042	44/115 (38%)
		CUB	840..951	CDD:278839	67/110 (61%)
		FXa_inhibition	958..993	CDD:291342	17/35 (49%)
		CUB	997..1111	CDD:278839	47/113 (42%)
		FXa_inhibition	1118..1153	CDD:291342	20/34 (59%)
		CUB	1158..1267	CDD:278839	53/108 (49%)
		CUB	1271..1390	CDD:238001	47/118 (40%)
bmp1b	XP_005155463.1	ZnMc_BMP1_TLD	109..303	CDD:239808	132/195 (68%)
		Astacin	111..303	CDD:279708	131/193 (68%)
		CUB	305..414	CDD:278839	44/115 (38%)
		CUB	418..527	CDD:278839	67/110 (61%)
		EGF_CA	530..570	CDD:214542	20/39 (51%)
		CUB	575..684	CDD:278839	47/113 (42%)
		FXa_inhibition	691..726	CDD:291342	20/34 (59%)
		CUB	731..840	CDD:278839	53/108 (49%)
		CUB	844..957	CDD:278839	46/116 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1534
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	990	1.000	Inparanoid score	I294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm6442
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900