DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and cuzd1.2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	XP_021323075.1	Gene:	cuzd1.2 / 555768	ZFINID:	ZDB-GENE-131119-30	Length:	718	Species:	Danio rerio

Alignment Length:	763	Identity:	179/763 - (23%)
Similarity:	267/763 - (34%)	Gaps:	223/763 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRD 904
            |||.||  ..:|...|||||..|.....|.|.|....:..|:|.|....:|   ||. ||:.|.:
Zfish    21 CGGSLS--SWMGEFTSPNYPNSYPDKARCTWTIHSTGAATVSLTFTDVFLE---SCC-DYIRVYN 79

  Fly   905 GPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSA--VFMKEVDECETQNHGCEH 967
            ||....||:|.....| ..:..||||.:.|.|.||..:.:.||.|  ||:        .::.|.:
Zfish    80 GPSTLYPLLGELVDEK-SKSYNSSGNDLTVLFFSDDEISRRGFHANWVFL--------DSNSCRN 135

  Fly   968 ECINTLGGYEC--SCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAP 1030
            .|..:.|...|  ||:       |.::|   |.....|...|.|.|:..:    :..|::.....
Zfish   136 YCGFSFGTCSCDDSCQ-------DNRNC---CFDYNSYCFQTTTWPTTTD----IPSCMYNCGYN 186

  Fly  1031 PKHRISLNFTHF---------DLEG--------TAHQQS---------DCGYD----SVTVYSKL 1065
            |.   |.:.|.|         |.|.        ||.:..         :|||:    |.|.:.:.
Zfish   187 PG---SCSCTDFCQRDGNCCPDYEAYCSETTTTTAFEPDTTEILSCMYNCGYNLGGCSCTEFCRS 248

  Fly  1066 GENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECR 1130
            ..|.......:|..:...|...::.|     ||  .:...|:      |:..|:     |..:|.
Zfish   249 YGNCCPDYEAYCSETTTTTFEPDTTA-----HS--CMYNCGY------DLGSCS-----CARDCH 295

  Fly  1131 NTIGSYICMCHNGYSMHENGHDC--------KEGECKYEISAP--------FGTIFSPNYPDSYP 1179
                 |..:|...|..|     |        ...|..|..|.|        .|...:||||..|.
Zfish   296 -----YYDICCPDYDSH-----CPSYTTLRDSTTELHYTESHPKCGGHLYGAGLFSTPNYPSYYH 350

  Fly  1180 PNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFC-GDKIPFPISS 1243
            .||.|||:.....|.||.|.|  .||:..:.|..|.:.::||.|.....||..| .|.......|
Zfish   351 DNAYCVWYLSAQQGQRIFLTF--ADVQLERCCDCDYITIHDGSSTGYPQLGNVCFNDTTHQAFHS 413

  Fly  1244 TSNQMYMVLKTDKNKQKNGFTA---SHSTACGGYLRATSQ-----VQQFY--SHARFGNQDYDDG 1298
            ||..:.:|.::|.:...:||.|   |..||..|.:..:|.     :::.|  |....||..|.|.
Zfish   414 TSRYLTVVFRSDFSGVSHGFKAHFTSSLTADQGRVDCSSDNMVIVLRRSYLNSLGFSGNDLYVDD 478

  Fly  1299 MDCEWTIAAPD-----------------NSYVQLIFLTFDIESSEN----------------CTF 1330
            ..|...|::.:                 ||:|.   .|.::.:|.:                |..
Zfish   479 RLCRPNISSTEVVFRFPLNTCGTAKKMMNSFVS---YTNNVRASPSQSGVITRQSEFLLSVGCRM 540

  Fly  1331 D---YVQVFSDIDDV-------YGQYGPMYGQYCGNVLPQDINSMTHSL-----------LVRFK 1374
            :   .||:|...:::       .|::......|......|.|....:.:           |.||
Zfish   541 EPDTIVQIFYKAEEIPNGNITGTGRFNASIAFYTSRKFNQQIYDSPYEVYLNDDLFVQVKLTRF- 604

  Fly  1375 TDGSVPMKGFSASYVAVPNSGEY-DHSDEDVENSYSSEMVTPFPGSLKSIYIEDTQEETDEYSDF 1438
             |.|:.:  |..:.||.||..:: |:|.:.:.|.      .|...:.:| ||..    .|:|:.|
Zfish   605 -DASLDL--FLETCVASPNPNDFKDYSYDLLRNG------CPRDSTFQS-YING----VDQYAQF 655

  Fly  1439 SGNQLVF---------------------------NGQYRGRYSLPKRY 1459
            |.....|                           ..|||.:.||...|
Zfish   656 SFRAFKFLQTHAYVHLQCQVIICPDNDYNSRCRKGCQYRRKRSLDSSY 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		Astacin	527..721	CDD:279708
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839	41/112 (37%)
		FXa_inhibition	958..993	CDD:291342	7/36 (19%)
		CUB	997..1111	CDD:278839	26/143 (18%)
		FXa_inhibition	1118..1153	CDD:291342	7/34 (21%)
		CUB	1158..1267	CDD:278839	38/120 (32%)
		CUB	1271..1390	CDD:238001	29/179 (16%)
cuzd1.2	XP_021323075.1	CUB	21..127	CDD:238001	41/112 (37%)
		Somatomedin_B	131..164	CDD:307259	9/42 (21%)
		Somatomedin_B	175..214	CDD:321959	7/45 (16%)
		Somatomedin_B	<239..260	CDD:307259	3/20 (15%)
		CUB	330..439	CDD:238001	35/110 (32%)
		ZP	450..694	CDD:214579	45/261 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810