DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and tll2l

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001016661.1	Gene:	tll2l / 549415	XenbaseID:	XB-GENE-478930	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	149/446 - (33%)
Similarity:	223/446 - (50%)	Gaps:	29/446 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 RVARAVTAKKERIWDYG-----VIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPN 575
            ||.|:........||..     .:|:.:...::....||...||:.:|..||:.||   |:.:..
Frog    68 RVVRSSLQCDNCKWDISSNGKVPVPFTVSPGYTKSQLALITAAMQEFETLTCVDFV---PKTNEK 129

  Fly   576 YIVFTVRSCGCCSFVGKRGNGPQAISIGR-NCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEH 639
            .::......||.|::|:.| |.|.:|:.: :|...||:.|||.||:||.|||.|.||:::|.:..
Frog   130 NVININNGNGCWSYIGRSG-GVQQVSLSKQSCMVKGIIQHELNHVLGFVHEHVRSDRDQYVNVVK 193

  Fly   640 NNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRL 704
            .||:.....||::.   ..::||:.|||.|:|||.||.||...:|.|::   .|.....:||||.
Frog   194 KNILPDSLGNFDIA---VTNNLGLPYDYYSVMHYPRNAFSISPFLPTLI---TKPDPTIQIGQRY 252

  Fly   705 RLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLE 769
            .|:..|||:.|.||.|..|.....:.:|...|||:.:|   ..:..:|.|.|... ..:|.::..
Frog   253 GLTNLDIAKINKLYNCDVCSTLLSDVNGTLFSPSYPSA---YPDNANCVWLIRIP-SNQVSVQFI 313

  Fly   770 NMNIFKSNNCETDYLEIRDGYFEKSP-LIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEG--FRG 831
            ..::..|.||.:||::|.||.....| |:.:.||.:....|...|:.|||.:|:.   ||  ..|
Frog   314 AFSLQTSQNCVSDYVKIYDGATRSDPVLLDKACGSLLLPPITASSNLMLLEFVSN---EGNTMTG 375

  Fly   832 FKAEFDVV-CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSC 895
            |:|.:..| |||..:...  ....||.||:.|.|...|:|.|..|..:::.|.....|||....|
Frog   376 FEATYSTVSCGGTYTSQS--NSFSSPGYPVAYPPLTTCIWSIYAPVGFKIVLTINKIEVEYGLLC 438

  Fly   896 VYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVF 951
            :||.:.:.||....||::...||....||..|.|.||.:.|.||.||||.||.|.:
Frog   439 MYDSLTIYDGYNTTAPILRCACGNTAVPNQISRGRSMLLVFSSDISVQKKGFQASY 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	69/206 (33%)
		Astacin	527..721	CDD:279708	69/199 (35%)
		CUB	723..836	CDD:294042	33/115 (29%)
		CUB	840..951	CDD:278839	42/110 (38%)
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
tll2l	NP_001016661.1	ZnMc_hatching_enzyme	86..268	CDD:239810	67/191 (35%)
		CUB	272..382	CDD:238001	32/116 (28%)
		CUB	385..495	CDD:238001	42/112 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1004	1.000	Inparanoid score	I296
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm9341
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.090