Protein Alignment tok and PCOLCE

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_002584.2
• Gene: PCOLCE / 5118
• HGNCID: 8738
• Length: 449
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 94/277 - (33%)
• Similarity: 141/277 - (50%)
• Gaps: 42/277 - (15%)

  Fly   839 VCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVR 903
            :|||::..:.  |.:.|..:|..|.|||||:|.|||||...|:|.|:.|::|.|.:|.||.:||.
Human    36 LCGGDVKGES--GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVF 98

  Fly   904 DGPGQDAPLIGVFCG-YKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEH 967
            .|.|.....:|.||| ::|.| :.:.||.:.::..:|......||...:....      ..|.||
Human    99 AGSGTSGQRLGRFCGTFRPAP-LVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA------TSGTEH 156

  Fly   968 ECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEM-YPLLKECIWEIVAPP 1031
            :                           .|||.:|...||:|:|::||. ||....|.|.|:|||
Human   157 Q---------------------------FCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPP 194

  Fly  1032 KHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEF 1096
            ...|:|.|..||||...:    |.||||:|::....:..:|:|.|||.::|.:.:||.|.|.::|
Human   195 DQVIALTFEKFDLEPDTY----CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQF 255

  Fly  1097 HSDKSIQRSGFAAVFFT 1113
            .||.|:...||:|.:.|
Human   256 VSDLSVTADGFSASYKT 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		CUB	723..836	CDD:412131
		CUB	840..951	CDD:395345	42/111 (38%)
		FXa_inhibition	958..993	CDD:464251	3/34 (9%)
		CUB	997..1111	CDD:395345	48/114 (42%)
		FXa_inhibition	1118..1153	CDD:464251
		CUB	1158..1267	CDD:395345
		CUB	1271..1390	CDD:238001
PCOLCE	NP_002584.2	CUB	37..147	CDD:238001	42/112 (38%)
		CUB	159..270	CDD:238001	48/114 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..321		1/2 (50%)
		NTR_PCOLCE	313..437	CDD:239631