DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and tll1

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_571085.1	Gene:	tll1 / 474335	ZFINID:	ZDB-GENE-041020-1	Length:	1022	Species:	Danio rerio

Alignment Length:	956	Identity:	463/956 - (48%)
Similarity:	639/956 - (66%)	Gaps:	57/956 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 QQQHHRRRGQSTTQYVNHSPP----------------GF-----NQSQQAQQQSVPEMDLLKAET 506
            :||.|.|:|.::.....|.|.                ||     |.|:..   |..:..:.:..:
Zfish    85 KQQTHGRQGHTSGGLGEHVPTKKRGSLYLLLDRIRRLGFESWPVNSSKDV---SSIKTGIRRVNS 146

  Fly   507 SKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPE 571
            :::   ::.||.||.|::.|:||..|||||.|.|||:|..:|:.|.||||||..||:.|:|:..|
Zfish   147 ARN---VKSRVPRAATSRAEKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTDE 208

  Fly   572 IHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVV 636
              .:|||||.|.|||||:||:|||||||||||:|||||||||||||||:|||||||||||:.||.
Zfish   209 --ESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVT 271

  Fly   637 IEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIG 701
            |..:||..||:|||..:.|.:|:|||..||:||||||||||||:|.:||||||...:...||.||
Zfish   272 IIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIG 336

  Fly   702 QRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSH------YTAGALSNETEHCEWRITATY 760
            ||.|||:|||:||..||:||.||.|.|:|.|.|:||.:      ||         ||.|||:.|.
Zfish   337 QRTRLSKGDISQAKKLYRCPACGETLQDSVGNFSSPGYPNGYPSYT---------HCVWRISVTP 392

  Fly   761 GERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHR 825
            ||::.|....|:::||:.|..||:|:||||:.|:||:|||||....||:.:..|||.:.:.::..
Zfish   393 GEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEFRSSSN 457

  Fly   826 IEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVE 890
            ..| :||.|.::.:||||:|.|.  |:::|||||.||.|:|||||:|||.|.|.|.|.||.||:|
Zfish   458 WVG-KGFAAVYEAICGGEISKDS--GQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQVFEIE 519

  Fly   891 NHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEV 955
            .||||.|||:|||||..:::||||.||||..|.:::|:.|::::|||||.:|.||||:|.|.||.
Zfish   520 RHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKAGFAANFFKEE 584

  Fly   956 DEC-ETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPL 1019
            ||| :..|.|||..|:||||.::|:|..|:||..|||.||.||||::...|||||:|.:|:.||.
Zfish   585 DECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLLTKLNGTITTPGWPKEYPP 649

  Fly  1020 LKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPT 1084
            .|.|:|::|||.::|||:.|..|:|||    ...|.||.|.|.|.|..:. |..|.:||:.:|..
Zfish   650 NKNCVWQVVAPTQYRISMQFEAFELEG----NEVCKYDYVEVRSGLSSDS-KLHGKYCGTEVPEV 709

  Fly  1085 ATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHEN 1149
            .||:.|.:|:||.||.::.:.||.|.||:|.|||:.:||||||||.||||||:|.|.||:.:|||
Zfish   710 ITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTIGSYVCQCRNGFILHEN 774

  Fly  1150 GHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYD 1214
            .|||||.||:::|.:..|||.|||:||.||...:|.|....|||||:|:.||||::|.||||.||
Zfish   775 KHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPGHRVKISFNEFEIEQHQECAYD 839

  Fly  1215 NVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATS 1279
            ::..:||:|:.:.:|.|.||:|||.|:.||.|:||:...:|.:.|:.||.|:|||.|||.|:|.:
Zfish   840 HLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMYLRFISDASVQRKGFQATHSTECGGRLKAEA 904

  Fly  1280 QVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYG 1344
            :.:..||||:||:.:|....||||.|.|.....::|.|.||::|...:|.:||::::    |.|.
Zfish   905 RQKNLYSHAQFGDNNYPGHTDCEWLIVAESGYGIELTFTTFEVEEEADCGYDYIELY----DGYD 965

  Fly  1345 QYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVA 1390
            ......|::||:...:::.|...::|:.|.:|.::..|||...|.:
Zfish   966 TGAHKIGRFCGSGPREELYSAGDAVLIHFHSDDTISKKGFHIRYTS 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	130/200 (65%)
		Astacin	527..721	CDD:279708	127/193 (66%)
		CUB	723..836	CDD:294042	48/118 (41%)
		CUB	840..951	CDD:278839	66/110 (60%)
		FXa_inhibition	958..993	CDD:291342	18/35 (51%)
		CUB	997..1111	CDD:278839	49/113 (43%)
		FXa_inhibition	1118..1153	CDD:291342	23/34 (68%)
		CUB	1158..1267	CDD:278839	52/108 (48%)
		CUB	1271..1390	CDD:238001	39/118 (33%)
tll1	NP_571085.1	ZnMc_BMP1_TLD	157..356	CDD:239808	130/200 (65%)
		Astacin	164..357	CDD:279708	128/194 (66%)
		CUB	358..467	CDD:278839	48/118 (41%)
		CUB	471..580	CDD:278839	66/110 (60%)
		FXa_inhibition	591..623	CDD:291342	17/31 (55%)
		CUB	627..736	CDD:278839	49/113 (43%)
		FXa_inhibition	743..778	CDD:291342	23/34 (68%)
		CUB	783..892	CDD:278839	52/108 (48%)
		CUB	896..1009	CDD:278839	38/116 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1534
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49202
Inparanoid	1	1.050	990	1.000	Inparanoid score	I294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm6442
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	LDO	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900