DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and pcolce2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001005804.1	Gene:	pcolce2 / 448281	XenbaseID:	XB-GENE-1015978	Length:	416	Species:	Xenopus tropicalis

Alignment Length:	312	Identity:	103/312 - (33%)
Similarity:	141/312 - (45%)	Gaps:	59/312 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRD 904
            |||.|:.|  .|.|.|..:|..|.||.:|.|||||||...|.|.|:..::|:.:.|.||:|:|.:
Frog    34 CGGNLTGD--TGVLGSEGFPGVYPPNSKCTWKITVPEGKVVVLSFRFIDLESDNLCRYDFVDVYN 96

  Fly   905 GPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHEC 969
            | ..:...||.|||...|..:.|:.|.|.|:.:||.:....||.|||    ...|....|.::
Frog    97 G-HSNVHRIGRFCGTFRPGALVSNSNKMLVQMISDANTAGNGFIAVF----SAAEPNERGDQY-- 154

  Fly   970 INTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEM-YPLLKECIWEIVAPPKH 1033
                                       |||.::.|:|:..:|::||. ||....|.|.||||...
Frog   155 ---------------------------CGGRLDKPSGSFQTPNWPERDYPAGVTCSWHIVAPKHQ 192

  Fly  1034 RISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHS 1098
            .|.|.|..||:|    :.:.|.||.|.|::....|..||||.|||.|.|....||.|.|.::|.|
Frog   193 VIELKFEKFDVE----RDNYCRYDYVAVFNGGEINDAKRIGKFCGDSPPAPIVSERNELLIQFLS 253

  Fly  1099 DKSIQRSGFAAVF-----------FTDIDECAVNNGG-------CQHECRNT 1132
            |.|:...||.|.:           .:.|...|.....       ||.:|:.|
Frog   254 DLSLTADGFKAHYRFRPKKLPTTTVSPITTPAATTPSLKPTLALCQQKCKRT 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		Astacin	527..721	CDD:279708
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839	45/110 (41%)
		FXa_inhibition	958..993	CDD:291342	2/34 (6%)
		CUB	997..1111	CDD:278839	48/114 (42%)
		FXa_inhibition	1118..1153	CDD:291342	5/22 (23%)
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
pcolce2	NP_001005804.1	CUB	34..144	CDD:238001	47/116 (41%)
		CUB	155..266	CDD:366096	48/114 (42%)
		NTR_PCOLCE	293..416	CDD:239631	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000