DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and ASTL

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	XP_011509507.1	Gene:	ASTL / 431705	HGNCID:	31704	Length:	436	Species:	Homo sapiens

Alignment Length:	272	Identity:	90/272 - (33%)
Similarity:	128/272 - (47%)	Gaps:	57/272 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 SPPGFNQSQQAQQQSVPEMD--LLKAETSKDE--------EPLRHRVARAVTAKKERIWDYG--- 532
            :|.|   :|.:..:.:|.::  |:..||.:..        .|...|:..|.:.|    |..|
Human    48 TPEG---TQASGDKDIPAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNK----WPMGGSG 105

  Fly   533 --VIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFV----ERD-PEIHPNYIVFTVRSCGCCSFV 590
              .:|:.:...:....:.:...|:..:|.||||:||    :|| ..|.|.|        ||.|.|
Human   106 VVEVPFLLSSKYDEPSRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMY--------GCFSSV 162

  Fly   591 GKRGNGPQAISIGRNC--DKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNF--- 650
            |:.| |.|.:|:...|  ...|||:|||.||:||||||||.||::::.:..|.|:.|.:.||
Human   163 GRSG-GMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKS 226

  Fly   651 ---NMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIA 712
               |||:|         |||.|:|||.|..||: ..|.||.|:   ......||||..||..||.
Human   227 QSSNMLTP---------YDYSSVMHYGRLAFSR-RGLPTITPL---WAPSVHIGQRWNLSASDIT 278

  Fly   713 QANLLYKCPKCG 724
            :...||.|...|
Human   279 RVLKLYGCSPSG 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	79/218 (36%)
		Astacin	527..721	CDD:279708	77/211 (36%)
		CUB	723..836	CDD:294042	1/2 (50%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
ASTL	XP_011509507.1	Astacin	97..288	CDD:279708	79/216 (37%)
ASTL	XP_011509507.1	ZnMc	105..286	CDD:294052	75/202 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810