DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and Nrx-1

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster

Alignment Length:	1162	Identity:	209/1162 - (17%)
Similarity:	350/1162 - (30%)	Gaps:	429/1162 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 PGFNQSQQAQQQSVPEMDLLKAE---TSKDEEP-LRHRVAR---------AVTAKKERIWDYGVI 534
            |..:..|| :.::..|:.||.|:   ||..|.| ||...||         .|..:..|.:...::
  Fly    24 PSMDMDQQ-RNRNQAELRLLPAQRTSTSAFESPDLRFNKARRRRRSEQVPPVVVEYRRSYRVLIV 87

  Fly   535 P----------------YEIDGNFSGIHKALFKLAMRHWE---NSTC-IKFVERDPEIHPNYIVF 579
            .                :::||:.:..:      ..|.|.   |.|. ::|...    .||.:|.
  Fly    88 SALLVSLAASFVTLSAGFQLDGSQNSFY------TFRKWYTGLNGTLELEFKTE----QPNGLVL 142

  Fly   580 TVRSCGCCSFVGKR------------GNGPQAISIGRNCDKFGIVVHELGHVVGFWH--EHTRPD 630
            .....|...|...:            |.|.|.|::||.       :|:     |.||  :..|.|
  Fly   143 YTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRE-------LHD-----GHWHKVQVLRND 195

  Fly   631 REKHVVIE---HNNIMKGQDYNF-NMLSPDEVDSLGMAYDYDS---IMHYARNTFS---KGTYLD 685
            .:..::::   .....||:::.| ...|..:|...||...|.|   ::......|.   :|...:
  Fly   196 EQTSLIVDGVSQQRSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRN 260

  Fly   686 TILPIEMKG-RKRPEIGQRLRLSQGDIAQANLLYKC-----PKCGRTFQESSGIFASPSHYTAGA 744
            .:...:..| .:|.||.|:..:..||:       .|     |...|..:...|
  Fly   261 LVYADQPGGSTRRQEIKQQRDIKCGDV-------PCDHGELPARERPLRGVRG------------ 306

  Fly   745 LSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVI 809
             .|.|:.||......:| .:.:..::..|.:..|.|.|               |::|   :||..
  Fly   307 -GNTTDACERNDPCQHG-GICISTDSGPICECRNLEYD---------------GQYC---EKEKA 351

  Fly   810 RTESSRMLLTYVNTHRIEGFRGFK-AEFDV-VCGGE--LSVDDAVG---RLESPNYPLDYLPNKE 867
            .:|::              |||.: ..:|: ..|.|  :|..||:.   |...||..|.|
  Fly   352 PSEAT--------------FRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFY----- 397

  Fly   868 CVWKITVPESYQVALKFQSFEVENHDSCVYDYVE--VRDGPGQDAPLIGVFCGYKPPPNMKSSGN 930
                                  ..|.:   ||:.  :|||            |......:.:...
  Fly   398 ----------------------TGHGT---DYLNLALRDG------------GVSLTMGLANGKQ 425

  Fly   931 SMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCE-HECINTLGGYECSCR---IGFELHSDKK 991
            .|::|      ..|..|.          :.|.|... |..|..:......||   :..::::|..
  Fly   426 EMHIK------PSKVRFD----------DHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHS 474

  Fly   992 HCEDA----------CGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDL-- 1044
            |....          .||.:. |...:.:.........|::.  |..|.     :||....||
  Fly   475 HIAGKFTMLSSSRVYVGGAVN-PRALLGARVHTNFVGCLRKV--EFSAD-----TLNLNLIDLAK 531

  Fly  1045 --------EGTAHQQSDCG--YDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSD 1099
                    .|....|...|  .|.||..::  |:.|         .:||..|.:.:::..:|
  Fly   532 SGSKLIQVAGNLEYQCPSGDPQDPVTFTTR--ESHL---------VLPPWETGKQSSISFKF--- 582

  Fly  1100 KSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGH-----DCKEGECK 1159
            ::.:.:|.          ..:..|..|...:|.:...|.:.        |||     |...|..|
  Fly   583 RTKEPNGI----------IVLATGSKQPRAKNPVLIAIELL--------NGHIYIHLDLGSGASK 629

  Fly  1160 YEISAP-------FGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQ-------- 1209
            ...|..       ...|...|..|: ..:.|.||:...|||....|     :::.|.
  Fly   630 VRASRRRVDDGDWHDLILRRNGRDA-KVSVDGVWNDFRTPGDGTIL-----ELDGHMYLGGVGPA 688

  Fly  1210 --------------------ECTYD--------NVAVYDGESESSSVL----------------- 1229
                                .|..|        ::|.:....:|:||.
  Fly   689 YNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPCLN 753

  Fly  1230 GRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQD 1294
            |..|.:....||...|..:|           .|.|      ||..|...:.....:.....||..
  Fly   754 GGTCLEGWNRPICDCSATLY-----------GGPT------CGRELATLAFNGSQHMTIWLGNGQ 801

  Fly  1295 YDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQV------------FSDIDDVYGQYG 1347
            .......|..|....:....|:.||    |:|:.:.|.:::            .||.:.
  Fly   802 GTKTQTEELVIRFKTSRPAGLLLLT----SAESNSPDRLEIALVAGRVRASVRLSDREK------ 856

  Fly  1348 PMYGQYCGNVLPQDINSMT-----HSLLVRFKTDGSVPMKGFSASYVAVPNS---------GEYD 1398
               ....|..:..|.|..|     .:..:|.:.||:.|::|..:..:...:|         |...
  Fly   857 ---NLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLF 918

  Fly  1399 HSDEDVENSYSSEMVTPFPGSLKSIYIEDTQEETDEYSDFSGNQ--LVFNGQYRGRY 1453
            |::|::      :|.:..|                   :|.|..  ||||||   ||
  Fly   919 HAEEEI------QMTSTMP-------------------NFVGQMQGLVFNGQ---RY 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	45/250 (18%)
		Astacin	527..721	CDD:279708	44/243 (18%)
		CUB	723..836	CDD:294042	19/113 (17%)
		CUB	840..951	CDD:278839	21/117 (18%)
		FXa_inhibition	958..993	CDD:291342	7/38 (18%)
		CUB	997..1111	CDD:278839	23/125 (18%)
		FXa_inhibition	1118..1153	CDD:291342	7/39 (18%)
		CUB	1158..1267	CDD:278839	27/168 (16%)
		CUB	1271..1390	CDD:238001	24/135 (18%)
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058	33/174 (19%)
		EGF_CA	311..347	CDD:238011	9/54 (17%)
		Laminin_G_2	386..517	CDD:280389	28/191 (15%)
		LamG	555..716	CDD:238058	33/198 (17%)
		EGF	746..777	CDD:278437	7/41 (17%)
		Laminin_G_2	814..945	CDD:280389	29/168 (17%)
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444867
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930