DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and MEP1B

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	802	Identity:	180/802 - (22%)
Similarity:	274/802 - (34%)	Gaps:	243/802 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 MDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCI 563
            :||.:.:...|    |.::..::..:|.| |.: .|||.::.:.....|.:...|...:...|||
Human    46 LDLFEGDIRLD----RAQIRNSIIGEKYR-WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCI 104

  Fly   564 KFVERDPEIHPNYI-VFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHT 627
            .|.....|  .||| ||  :..||.|.||.|..|.|.:|||.|||:...|.||..|.:|||||.:
Human   105 DFKPWAGE--TNYISVF--KGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQS 165

  Fly   628 RPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEM 692
            |.||:.:|.|..:.|:.|:::|||..|.|..|||.:.|||.|:|||::..|..||....:..|
Human   166 RSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRI-- 228

  Fly   693 KGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRIT 757
             ......||||:..|..|:.:.|.||.| ....:|.:|...   ......|.:.:..::.:|:..
Human   229 -SDFEDVIGQRMDFSDSDLLKLNQLYNC-SSSLSFMDSCSF---ELENVCGMIQSSGDNADWQRV 288

  Fly   758 ATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVN 822
            :......|....||     ..|:      ..|:|.          ..|...:...::.:|    .
Human   289 SQVPRGPESDHSNM-----GQCQ------GSGFFM----------HFDSSSVNVGATAVL----E 328

  Fly   823 THRIEGFRGFKA-EFDVVCGG-----------ELSVDDAVGRL----ESPNYPLDYLPNKECVWK 871
            :..:...|||:. :|.:...|           |.|.|:..|.|    |....|..       .|:
Human   329 SRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTG-------SWQ 386

  Fly   872 ITVPESYQVALKF-QSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVK 935
            :     |.|.||. :.|.|                         ||.|      .|.||.|:
Human   387 L-----YHVTLKVTKKFRV-------------------------VFEG------RKGSGASL--- 412

  Fly   936 FVSDTSVQKAGFSAVFMKEVDECETQNHGCEHEC--INTLGGYECSCRIGFELHSDKKHCEDACG 998
                     .|.|      :|:.......|.|..  |.....:
Human   413 ---------GGLS------IDDINLSETRCPHHIWHIRNFTQF---------------------- 440

  Fly   999 GVIEYPNGTITSPSF--PEMYPLLKECIWEIVAPPKHRISLNFTH-------FDLEGTAHQ---Q 1051
              |..||||:.||.|  .:.|..              :|.||..|       |.|...|:.   |
Human   441 --IGSPNGTLYSPPFYSSKGYAF--------------QIYLNLAHVTNAGIYFHLISGANDDQLQ 489

  Fly  1052 SDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAV----FF 1112
            ..|.:...|:                      |...::..:|....:.:||....|...    :|
Human   490 WPCPWQQATM----------------------TLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYF 532

  Fly  1113 TD----IDECAVNNGGCQHECRNTIGSYICMCHNGYSMHE--NGHDCKEGECKYEISAPFGTIFS 1171
            .|    :...|:.:.|.|.......|:      :.:..||  ...|..:|:..|.:.    |:..
Human   533 WDRPSKVGTVALFSNGTQFRRGGGYGT------SAFITHERLKSRDFIKGDDVYILL----TVED 587

  Fly  1172 PNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNV-AVYDGESESSS-------V 1228
            .::.:|        .....||...::      |:.|...|..|.| .|.||::|...       .
Human   588 ISHLNS--------TQIQLTPAPSVQ------DLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWY 638

  Fly  1229 LGRFC------GDKIPFPISST 1244
            :|..|      .|.|...:|||
Human   639 MGERCEKRGSTRDTIVIAVSST 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	76/201 (38%)
		Astacin	527..721	CDD:279708	75/194 (39%)
		CUB	723..836	CDD:294042	15/113 (13%)
		CUB	840..951	CDD:278839	24/126 (19%)
		FXa_inhibition	958..993	CDD:291342	3/36 (8%)
		CUB	997..1111	CDD:278839	24/129 (19%)
		FXa_inhibition	1118..1153	CDD:291342	6/36 (17%)
		CUB	1158..1267	CDD:278839	21/101 (21%)
		CUB	1271..1390	CDD:238001
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	80/221 (36%)
		Astacin	69..257	CDD:279708	76/197 (39%)
		MAM	260..427	CDD:214533	41/255 (16%)
		MAM	265..427	CDD:99706	39/250 (16%)
		MATH	427..586	CDD:295307	39/228 (17%)
		Required for proteolytic processing	595..607		2/17 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810