DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tok and MEP1A

DIOPT Version :9

Sequence 1:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:XP_011512930.1 Gene:MEP1A / 4224 HGNCID:7015 Length:774 Species:Homo sapiens


Alignment Length:771 Identity:178/771 - (23%)
Similarity:269/771 - (34%) Gaps:207/771 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   492 QQQSVPE------MDLLKAE--TSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKA 548
            :|:.:.|      :||.:.:  ..|....||....|         |.: .|||.:..|.....|.
Human    67 EQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTR---------WTF-PIPYILADNLGLNAKG 121

  Fly   549 LFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVV 613
            ....|...:...:|:.|...:.|  .:||:|. :..||.|.||.:..| |.||||:.|....|:.
Human   122 AILYAFEMFRLKSCVDFKPYEGE--SSYIIFQ-QFDGCWSEVGDQHVG-QNISIGQGCAYKAIIE 182

  Fly   614 HELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTF 678
            ||:.|.:||:||.:|.||:.:|.|..:.|:.|..:||:......:..|...|||:|:|||...:|
Human   183 HEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSF 247

  Fly   679 SKGTYLDTILPIEMKGRKRPE----IGQRLRLSQGDIAQANLLYKCPK---------------CG 724
            :|...:.||.      .|.||    |||||..|..|:.:.|.:|.|..               ||
Human   248 NKNASVPTIT------AKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICG 306

  Fly   725 R----------TFQES----------------SGIFASPSHYTAGALSNETEHCEWRITATYGER 763
            .          ..|:|                :|.|...|  |:...:.|....|.||  .|.:|
Human   307 MIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFS--TSSGSAEEAALLESRI--LYPKR 367

  Fly   764 VELKLENMNIFKSNNCETDYLEI---RD---GYFEKSPLIGRFCG------KVDKEVIRTESSRM 816
            .:..|:  ..:|.....:|.|.:   ||   |...|...:..|.|      |:...|::.|....
Human   368 KQQCLQ--FFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFR 430

  Fly   817 LLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKI----TVPES 877
            .|          |:|.|.:.....|| :.:||..         |...|....||.:    .|.|:
Human   431 YL----------FQGTKGDPQNSTGG-IYLDDIT---------LTETPCPTGVWTVRNFSQVLEN 475

  Fly   878 YQVALKFQS---FEVENHDSCVYDYVEVRDGPG---------------------QDAPLIGVFCG 918
            .....|.||   :..|.:...|..|...|:..|                     ::..:|.....
Human   476 TSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILD 540

  Fly   919 YKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLG-GYECSCRI 982
            .:|....:.|.:.::....|.||  .|....|.........|.:..|  .|..::. |:.     
Human   541 QEPDVRNRMSSSMVFTTSKSHTS--PAINDTVIWDRPSRVGTYHTDC--NCFRSIDLGWS----- 596

  Fly   983 GFELHSDKKH-----CEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHF 1042
            ||..|...|.     .:|.   :|......||..|..|:             |.|.: .|:....
Human   597 GFISHQMLKRRSFLKNDDL---IIFVDFEDITHLSQTEV-------------PTKGK-RLSPQGL 644

  Fly  1043 DLEGTAHQQSDCG------YDSVTVYSKLGE-NRLKRIGTFCGSSIPPTATSESNALRLEFHSDK 1100
            .|:|...|.|:.|      .:::.|....|: :|.||              |..|...||.|:..
Human   645 ILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKR--------------SVENTGPLEDHNWP 695

  Fly  1101 SIQRSGFAAVFFTDIDECAVNNGGCQHE--CRNTIGSYICMCHNGYSMHENGHDCK 1154
            ...|           |.|..|  .||::  |.|..|...|.|.:|::....|..|:
Human   696 QYFR-----------DPCDPN--PCQNDGICVNVKGMASCRCISGHAFFYTGERCQ 738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808 66/204 (32%)
Astacin 527..721 CDD:279708 66/197 (34%)
CUB 723..836 CDD:294042 31/150 (21%)
CUB 840..951 CDD:278839 25/138 (18%)
FXa_inhibition 958..993 CDD:291342 8/40 (20%)
CUB 997..1111 CDD:278839 24/120 (20%)
FXa_inhibition 1118..1153 CDD:291342 11/36 (31%)
CUB 1158..1267 CDD:278839
CUB 1271..1390 CDD:238001
MEP1AXP_011512930.1 ZnMc_meprin 58..287 CDD:239809 74/239 (31%)
Astacin 101..289 CDD:279708 68/207 (33%)
MAM 292..459 CDD:214533 36/192 (19%)
MAM 297..459 CDD:99706 36/187 (19%)
MATH_Meprin_Alpha 459..622 CDD:239752 30/174 (17%)
EGF_CA 700..738 CDD:238011 12/39 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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