Protein Alignment tok and MEP1A

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: XP_011512930.1
• Gene: MEP1A / 4224
• HGNCID: 7015
• Length: 774
• Species: Homo sapiens
• Alignment Length: 771
• Identity: 178/771 - (23%)
• Similarity: 269/771 - (34%)
• Gaps: 207/771 - (26%)

  Fly   492 QQQSVPE------MDLLKAE--TSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKA 548
            :|:.:.|      :||.:.:  ..|....||....|         |.: .|||.:..|.....|.
Human    67 EQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTR---------WTF-PIPYILADNLGLNAKG 121

  Fly   549 LFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVV 613
            ....|...:...:|:.|...:.|  .:||:|. :..||.|.||.:..| |.||||:.|....|:.
Human   122 AILYAFEMFRLKSCVDFKPYEGE--SSYIIFQ-QFDGCWSEVGDQHVG-QNISIGQGCAYKAIIE 182

  Fly   614 HELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTF 678
            ||:.|.:||:||.:|.||:.:|.|..:.|:.|..:||:......:..|...|||:|:|||...:|
Human   183 HEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSF 247

  Fly   679 SKGTYLDTILPIEMKGRKRPE----IGQRLRLSQGDIAQANLLYKCPK---------------CG 724
            :|...:.||.      .|.||    |||||..|..|:.:.|.:|.|..               ||
Human   248 NKNASVPTIT------AKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICG 306

  Fly   725 R----------TFQES----------------SGIFASPSHYTAGALSNETEHCEWRITATYGER 763
            .          ..|:|                :|.|...|  |:...:.|....|.||  .|.:|
Human   307 MIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFS--TSSGSAEEAALLESRI--LYPKR 367

  Fly   764 VELKLENMNIFKSNNCETDYLEI---RD---GYFEKSPLIGRFCG------KVDKEVIRTESSRM 816
            .:..|:  ..:|.....:|.|.:   ||   |...|...:..|.|      |:...|::.|....
Human   368 KQQCLQ--FFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFR 430

  Fly   817 LLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKI----TVPES 877
            .|          |:|.|.:.....|| :.:||..         |...|....||.:    .|.|:
Human   431 YL----------FQGTKGDPQNSTGG-IYLDDIT---------LTETPCPTGVWTVRNFSQVLEN 475

  Fly   878 YQVALKFQS---FEVENHDSCVYDYVEVRDGPG---------------------QDAPLIGVFCG 918
            .....|.||   :..|.:...|..|...|:..|                     ::..:|.....
Human   476 TSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILD 540

  Fly   919 YKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLG-GYECSCRI 982
            .:|....:.|.:.::....|.||  .|....|.........|.:..|  .|..::. |:.
Human   541 QEPDVRNRMSSSMVFTTSKSHTS--PAINDTVIWDRPSRVGTYHTDC--NCFRSIDLGWS----- 596

  Fly   983 GFELHSDKKH-----CEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHF 1042
            ||..|...|.     .:|.   :|......||..|..|:             |.|.: .|:....
Human   597 GFISHQMLKRRSFLKNDDL---IIFVDFEDITHLSQTEV-------------PTKGK-RLSPQGL 644

  Fly  1043 DLEGTAHQQSDCG------YDSVTVYSKLGE-NRLKRIGTFCGSSIPPTATSESNALRLEFHSDK 1100
            .|:|...|.|:.|      .:::.|....|: :|.||              |..|...||.|:..
Human   645 ILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKR--------------SVENTGPLEDHNWP 695

  Fly  1101 SIQRSGFAAVFFTDIDECAVNNGGCQHE--CRNTIGSYICMCHNGYSMHENGHDCK 1154
            ...|           |.|..|  .||::  |.|..|...|.|.:|::....|..|:
Human   696 QYFR-----------DPCDPN--PCQNDGICVNVKGMASCRCISGHAFFYTGERCQ 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	66/204 (32%)
		CUB	723..836	CDD:412131	31/150 (21%)
		CUB	840..951	CDD:395345	25/138 (18%)
		FXa_inhibition	958..993	CDD:464251	8/40 (20%)
		CUB	997..1111	CDD:395345	24/120 (20%)
		FXa_inhibition	1118..1153	CDD:464251	11/36 (31%)
		CUB	1158..1267	CDD:395345
		CUB	1271..1390	CDD:238001
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	74/239 (31%)
		MAM	292..459	CDD:214533	36/192 (19%)
		MATH_Meprin_Alpha	459..622	CDD:239752	30/174 (17%)
		EGF	702..736	CDD:394967	11/35 (31%)