Protein Alignment tok and Nrx-IV

DIOPT Version :9

• Sequence 1: NP_001287510.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_524034.2
• Gene: Nrx-IV / 39387
• FlyBaseID: FBgn0013997
• Length: 1284
• Species: Drosophila melanogaster
• Alignment Length: 1050
• Identity: 194/1050 - (18%)
• Similarity: 312/1050 - (29%)
• Gaps: 388/1050 - (36%)

  Fly   532 GVIPYEIDG-----NFSGIHKALFKLAMRHWENSTCIKFVERD---------------------P 570
            |.:|...:|     ||||..:.::       .|||....|.:|                     |
  Fly   315 GGVPNVQEGLIVQQNFSGCLENIY-------FNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSP 372

  Fly   571 EIHPNYIVFTVRSCGCCSFVGKRG-NGPQAISIG---RNCDKFGIVVH-------------ELGH 618
            .|:|  :.||.||    |||..:| ...|.:::.   |..::.|:::|             |.|.
  Fly   373 PIYP--VTFTTRS----SFVRLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGYLKVFLEFGK 431

  Fly   619 VV----------------------GFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSL 661
            |.                      |.||...       :.||.|.::    .|.:........|:
  Fly   432 VKIDLKVKDKARIILDNYDDQFNDGKWHSFV-------ISIEKNRLI----LNIDQRPMTTTKSM 485

  Fly   662 GMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGR-KRPE---IGQRLRLSQGDIAQA-NLLYKC- 720
            .:|   ....:|......|..::..:..|.:.|. |.|:   .|:.:......:..| .::.:|
  Fly   486 QVA---TGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCN 547

  Fly   721 PK-C---GRTFQESSGIFASPSH--YTAGAL---SNETEHCEWRITATYGERVELKLENMNIFKS 776
            |. |   |...|.|...|....|  | |||:   ||....|             |.|:|:...:.
  Fly   548 PNPCQHKGLCHQNSREFFCDCGHTGY-AGAVCHTSNNPLSC-------------LALKNVQHVQQ 598

  Fly   777 N---NCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFR--GFKAEF 836
            .   |.:.|    ..|..|..|:...|..  |..||.|.|.    :..:|..::||:  |...:.
  Fly   599 RVNLNLDVD----GSGPLEPFPVTCEFYS--DGRVITTLSH----SQEHTTTVDGFQEPGSFEQS 653

  Fly   837 DVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFE--VENHDSCVYDY 899
            .:....:|.::..:.|..|....|.|......::     .|...|..|:.|.  :..|:..: ||
  Fly   654 IMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLF-----NSPSEAGNFRPFSWWISRHNQPM-DY 712

  Fly   900 VEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHG 964
                            :.|..|
  Fly   713 ----------------WAGALP------------------------------------------- 718

  Fly   965 CEHECINTLGGYECSCRIGFELHSDKKHC----------EDACGGVIEYPNGTITSPSFPEMYPL 1019
                     |..:|.|.|..:.|...|.|          ||  ||.|.
  Fly   719 ---------GSRKCECGILGKCHDPTKWCNCDSNSLEWMED--GGDIR----------------- 755

  Fly  1020 LKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTF----CGSS 1080
                       .|..:.:....|...||...:....|....:..: |::....:.||    ...:
  Fly   756 -----------EKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCE-GDDLFSNVVTFRIADASIN 808

  Fly  1081 IPPTATSESNALRLEFHSDKSIQRSG--FAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNG 1143
            :||.....|..:.|||   ::.|.:.  |.|...||..:.:: |||.:.:.:...||.....:.|
  Fly   809 LPPFDMGHSGDIYLEF---RTTQENSVIFHATGPTDYIKLSL-NGGNKLQFQYQAGSGPLGVNVG 869

  Fly  1144 YSMHENGHD---------------CKEGECKYEISAPFGTI------------FSPNYPDSYPPN 1181
            .|.|.|.::               ..:|..|.|:..|.|.:            .:..|.|.|
  Fly   870 TSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATTEYRDGY--- 931

  Fly  1182 ADCVWHFITTPGHRIKLIFNEFD--------------VESHQECTYDNVAV--YDGES---ESSS 1227
            ..|: ..:...|..:.|  .|:.              .||: .|..:...:  |||.|   ..|:
  Fly   932 VGCI-RALLLNGKMVDL--KEYSKRGLYGISTGCVGRCESN-PCLNNGTCIERYDGYSCDCRWSA 992

  Fly  1228 VLGRFCGDKIPFPISSTSNQMY----MVLKTDKNKQKNGFTAS---------HSTACGGYLRATS 1279
            ..|..|.|:|...:.|:|...|    ....|.....:.|||.:         .|...|.||  |.
  Fly   993 FKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIPKGFLLGFSSNLTGEYL--TI 1055

  Fly  1280 QVQQ-----------------FYSHARFGNQDYDD--------GMDCEWTIAAPDNSYVQLIFLT 1319
            |:..                 .:....||...|.|        |.    |:....::| :.:...
  Fly  1056 QISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGS----TVVLKVDNY-EPVEYN 1115

  Fly  1320 FDIESSENCTFDYVQVF------------------SDIDDVY------GQYGPMYGQYCGNVLPQ 1360
            |||::|.:..|:.:|..                  ...||:|      .|..|...:..|..|.:
  Fly  1116 FDIKASADAQFNNIQYMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTE 1180

  Fly  1361 D---INSMTH 1367
            |   :..:||
  Fly  1181 DFCGVEPVTH 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	48/259 (19%)
		Astacin	527..721	CDD:279708	48/259 (19%)
		CUB	723..836	CDD:294042	31/125 (25%)
		CUB	840..951	CDD:278839	14/112 (13%)
		FXa_inhibition	958..993	CDD:291342	6/34 (18%)
		CUB	997..1111	CDD:278839	20/119 (17%)
		FXa_inhibition	1118..1153	CDD:291342	9/49 (18%)
		CUB	1158..1267	CDD:278839	30/152 (20%)
		CUB	1271..1390	CDD:238001	27/148 (18%)
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572
		FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058	7/31 (23%)
		LamG	376..514	CDD:238058	28/157 (18%)
		EGF	546..575	CDD:278437	9/29 (31%)
		Laminin_G_2	824..943	CDD:280389	24/126 (19%)
		EGF_CA	966..998	CDD:238011	9/32 (28%)
		Laminin_G_2	1032..1156	CDD:280389	22/130 (17%)
		4.1m	1239..1255	CDD:128590

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930