DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and CG42255

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster

Alignment Length:	901	Identity:	220/901 - (24%)
Similarity:	353/901 - (39%)	Gaps:	234/901 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   630 DREKHVVIEHNNIMKGQDYNFNMLSPDEVDSL---------GMAYDYDSIMHYARN--------- 676
            |:::|:|...:|::        :||.....||         ||..:|:.:.:....
  Fly   923 DQKRHIVKSTDNLI--------LLSHSNRASLVFHGSGGGRGMRLEYNFVPNQCGGFLNEPGRRY 979

  Fly   677 -TFSKGTYLDTILPIEMKGRKR---------PEI-----------------GQRLRLSQGDIAQA 714
             |..:||:....  |:..|||:         |.|                 |....:..||:...
  Fly   980 VTAVRGTFCQWF--IDFPGRKKISIHTLGPTPSISIYDNSTSPGKLVNSYSGSVGDVFDGDLLTI 1042

  Fly   715 NLLYKCPK---------------CGRTFQESSGIFASPS---HYTAGALSNETEHCEWRITATYG 761
            ||....|:               ||.||....|...||:   :|      .|::.|||.:.|.:|
  Fly  1043 NLHTNWPRLEIYSIQFDIVQQDSCGGTFTARFGYIKSPNWPKNY------GESQMCEWILRAPFG 1101

  Fly   762 ERVELKLENMNI---FKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNT 823
            .|:||.:.|..:   :.|..|.||:||||:|..|.||||||:||......|.:..:.:.|.:.:.
  Fly  1102 HRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSD 1166

  Fly   824 HRIEGFRGFKAEFDVV---CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQ 885
            ..:|. :||...:..:   |||:||  .::|.:.||:..........|.|:|.|.|..:|:|:.:
  Fly  1167 DSMEE-KGFLLSWQQMGAGCGGKLS--SSMGTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLR 1228

  Fly   886 SFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAV 950
            |    |.:......:.:.|||...:..|.:.|.......::|:||.:.|::       ..|..|.
  Fly  1229 S----NDNRICSGQLTLYDGPTTASNPIVIRCNGTIAKPLQSTGNRVLVRY-------DVGHDAP 1282

  Fly   951 ----FMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSP 1011
                ||                 :|    |:.:||:..|             |:    .|.|.:|
  Fly  1283 DGTDFM-----------------LN----YQTNCRVRLE-------------GL----QGAIETP 1309

  Fly  1012 SFPEMYPLLKECIWEIVA-PPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGT 1075
            :|||.||..::|.|:|.| ..|:.:.|.|:|..:|..:   |.|..|.|::...|.:..|.....
  Fly  1310 NFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFS---SICLNDYVSLVDMLDDQTLSEQHL 1371

  Fly  1076 FCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMC 1140
            .....:.| .|:..|.|.|.|.||.|::..||.|.:         ...||
  Fly  1372 CTNDGLEP-ITTVGNRLLLRFKSDSSVELQGFRAEY---------KRIGC--------------- 1411

  Fly  1141 HNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDV 1205
              |..:.|:|                |...|||.|  :..:.||||....:.|::|:|:.:|...
  Fly  1412 --GEHLRESG----------------GRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYF 1456

  Fly  1206 ESHQ-ECTYDNVAVYDGES----------ESSSVLGRFCGDKIPF-PISSTSNQMYMVLKTDKNK 1258
            |:.| ||.       |.||          .||.||.|.|.::... ..:|..|::.:...:....
  Fly  1457 EAPQIECR-------DAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAP 1514

  Fly  1259 QKNGFTASH---STACGGYLRATSQV---QQFYSHARFGN-QDYDDGMDCEWTIAAPDNSYVQLI 1316
            .:..|.||.   ..:||||:.|:|.|   ..|::|....| .:|...::|.||:...:...::..
  Fly  1515 SRKYFKASFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPH 1579

  Fly  1317 FLTFDIESSENCTFDYVQVFS---DIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFK---- 1374
            |..|::..|.||:..:|::..   |..:::.:      :.||...|.........|.||||
  Fly  1580 FEQFNLTDSGNCSVSFVELTKLEPDNKEIFLE------KTCGEDSPMIRIVHGRKLRVRFKSQAG 1638

  Fly  1375 TDGSVPMKGFSASYVAVPNSGE-YDHSDEDVENSYSSEMVTPFPGSLKSIYIEDTQ 1429
            |.|...|. |........::|| |..|..|.|.|:   :||...||..|:.|...:
  Fly  1639 TWGRFIMY-FERQCGGRLSTGEGYLQSRLDEECSW---LVTSPEGSKLSLIINQLE 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	25/135 (19%)
		Astacin	527..721	CDD:279708	25/135 (19%)
		CUB	723..836	CDD:294042	41/118 (35%)
		CUB	840..951	CDD:278839	28/114 (25%)
		FXa_inhibition	958..993	CDD:291342	5/34 (15%)
		CUB	997..1111	CDD:278839	36/114 (32%)
		FXa_inhibition	1118..1153	CDD:291342	5/34 (15%)
		CUB	1158..1267	CDD:278839	30/120 (25%)
		CUB	1271..1390	CDD:238001	33/129 (26%)
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	11/47 (23%)
		CUB	1066..1179	CDD:238001	41/119 (34%)
		CUB	1185..1293	CDD:238001	32/141 (23%)
		CUB	1303..1406	CDD:238001	35/106 (33%)
		CUB	1411..1523	CDD:238001	34/153 (22%)
		CUB	1530..1648	CDD:238001	32/124 (26%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740