DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and Tll2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001178827.1	Gene:	Tll2 / 365460	RGDID:	1559756	Length:	1014	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	481/978 - (49%)
Similarity:	644/978 - (65%)	Gaps:	46/978 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 EHEVKLQRL--REELSRPVIEAHHHQSHHQKQAQHRQHHQSHHRKKHRRQQQHHRRRGQSTTQYV 478
            |.::||..:  .|:.::|.:|...|.:...::...|..:.:    ......|..|:.|:.:|..:
  Rat    69 EDDLKLFHIDKAEDWTKPSMERMGHDTGGLEETSARWPNDT----ASNSSIQALRKDGKDSTTLL 129

  Fly   479 NHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFS 543
                ||            |......|:|      ...||.||.|::.||||..|||||.|.|||:
  Rat   130 ----PG------------PGTSNTTAKT------FSARVRRATTSRTERIWPGGVIPYVIGGNFT 172

  Fly   544 GIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDK 608
            |..:|:||.||||||..||:.|:||..|  .::|||:.|:|||||:||:||.||||||||:||||
  Rat   173 GTQRAIFKQAMRHWEKHTCVTFIERTDE--ESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDK 235

  Fly   609 FGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHY 673
            ||||.||||||||||||||||||::||.|...||..||:|||..:...||.|||..||:||||||
  Rat   236 FGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHY 300

  Fly   674 ARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS 738
            ||||||:|.:||||||.......||.||||:||||||||||..|||||.||.|.|::||.|::|.
  Rat   301 ARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTSGNFSAPG 365

  Fly   739 HYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGK 803
             :..|..|  ..||.|||:.|.||::.|...:|::|||..|..||:||||||:.|:||:|||||.
  Rat   366 -FPNGYPS--YSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGD 427

  Fly   804 VDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKEC 868
            ...|.:.:..||:.:.:.::..|.| :||.|.::.:|||:::.|  .|:::|||||.||.|:|||
  Rat   428 KVPEPLVSSDSRLWVEFRSSSSILG-KGFFAVYEAMCGGDITKD--AGQIQSPNYPDDYRPSKEC 489

  Fly   869 VWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMY 933
            ||:|||.:.:.|.|.|||||:|.||||.|||:|:||||.:::.|||.||||:.|..:|||.|.::
  Rat   490 VWRITVADGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEESALIGHFCGYEKPEAVKSSANRLW 554

  Fly   934 VKFVSDTSVQKAGFSAVFMKEVDECETQNH-GCEHECINTLGGYECSCRIGFELHSDKKHCEDAC 997
            ||||||.|:.||||:|.|.||||||...:| |||..|:||||.|.|:|..|:||.::||.||.||
  Rat   555 VKFVSDGSINKAGFAASFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAANKKTCEVAC 619

  Fly   998 GGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVY 1062
            ||.|...|||||||.:|:.||..|.|:|::|||.::||||.|..|:|||    ...|.||.|.|.
  Rat   620 GGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPMQYRISLQFEAFELEG----NDVCKYDFVEVR 680

  Fly  1063 SKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQH 1127
            |.|..: .|..|.||||..|...||:||.:|:||.||.::.:.||.|.||:|.||||.:|||||.
  Rat   681 SGLSPD-AKLHGKFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQQ 744

  Fly  1128 ECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTP 1192
            ||.||.|||:|.|.|||.:|||||||||..|.|:||:..||:.|||:||.||...:|.|:..:|.
  Rat   745 ECVNTFGSYLCRCRNGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTA 809

  Fly  1193 GHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKN 1257
            |||:|:.|:||:||.||||.||::.:|||...|:.:||||||.|.|.|:.:|.:.:::...:|.:
  Rat   810 GHRVKITFSEFEVEQHQECAYDHLELYDGTDSSAPILGRFCGSKKPDPVVATGSSLFLRFYSDAS 874

  Fly  1258 KQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDI 1322
            .|:.||.|.|||.|||.|:|..|.::.||||:||:.:|.....|:|.|.|.|...|:|:|.||::
  Rat   875 VQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSQAHCDWVIVAEDGYGVELVFRTFEV 939

  Fly  1323 ESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSAS 1387
            |...:|.:||::.:    |.|....|..|::||:...::|.|...||::.|.||.::..|||.|.
  Rat   940 EEEADCGYDYLEAY----DGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIHFHTDDTINKKGFHAR 1000

  Fly  1388 YVA 1390
            |.:
  Rat  1001 YTS 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	133/200 (67%)
		Astacin	527..721	CDD:279708	130/193 (67%)
		CUB	723..836	CDD:294042	48/112 (43%)
		CUB	840..951	CDD:278839	65/110 (59%)
		FXa_inhibition	958..993	CDD:291342	18/35 (51%)
		CUB	997..1111	CDD:278839	55/113 (49%)
		FXa_inhibition	1118..1153	CDD:291342	24/34 (71%)
		CUB	1158..1267	CDD:278839	50/108 (46%)
		CUB	1271..1390	CDD:238001	45/118 (38%)
Tll2	NP_001178827.1	ZnMc_BMP1_TLD	149..348	CDD:239808	133/200 (67%)
		Astacin	156..349	CDD:279708	131/194 (68%)
		CUB	350..459	CDD:278839	48/112 (43%)
		CUB	463..572	CDD:278839	65/110 (59%)
		FXa_inhibition	583..615	CDD:291342	17/31 (55%)
		CUB	619..728	CDD:278839	55/113 (49%)
		FXa_inhibition	735..770	CDD:291342	24/34 (71%)
		CUB	775..884	CDD:278839	50/108 (46%)
		CUB	888..1001	CDD:278839	44/116 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1530
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1013	1.000	Inparanoid score	I270
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8929
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870