DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and nas-39

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001360030.1	Gene:	nas-39 / 3565986	WormBaseID:	WBGene00003555	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	898	Identity:	403/898 - (44%)
Similarity:	544/898 - (60%)	Gaps:	57/898 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 RVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFT 580
            ||:||.||||||||..|:||:.|..||||.|:.||..|||||||.||:.||.|.|. |.:||.||
Worm    44 RVSRAATAKKERIWPEGIIPFVIASNFSGEHQHLFLRAMRHWENFTCVSFVPRQPH-HKHYITFT 107

  Fly   581 VRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKG 645
            |..|||||:||:||.||||||||:|||||||||||||||||||||||||||:.:|.|.:.:|..|
Worm   108 VDKCGCCSYVGRRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDMYVDIFYKSIQTG 172

  Fly   646 QDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGD 710
            |||||....|:||||||..||:.|||||||:|||:|.:.|||||....| .|.|||||::||:||
Worm   173 QDYNFEKSKPEEVDSLGEPYDFSSIMHYARDTFSRGAFYDTILPKPNSG-FRLEIGQRVQLSEGD 236

  Fly   711 IAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIF- 774
            |.|...||||.:||.|..:.||..|. .|  ||.       |.|.|.:..|..:.|.:....:.
Worm   237 IRQTKKLYKCAECGGTLMQESGNLAI-QH--AGV-------CTWHIISPQGHTIFLNITGSTLSP 291

  Fly   775 KSNNC---ETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRT--ESSRMLLTYVNTHRIEGFRGFKA 834
            .|:.|   |.:.:.:|||....||::.|.||  ...:.||  .|...:|..|.:........| |
Worm   292 PSSLCGKEEDNVITVRDGVSISSPVLDRICG--GDSLFRTIASSGNRMLIQVRSSTPAASLPF-A 353

  Fly   835 EFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDY 899
            .:..:|||.:..::.|  :.||.||..|.||.:|.|.|.|.|:.|||::|..|.:|.|..|:||.
Worm   354 TYYAICGGPIYANEGV--IHSPKYPESYPPNSDCQWTIHVDENSQVAIEFVYFHLEQHKECIYDR 416

  Fly   900 VEVRDGPGQDAPLIG-----VFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECE 959
            :.:.:|..:::...|     .|||......:.|..|.:.::|.||.||||.||...|.||::||.
Worm   417 LILTEGISKNSKKDGKEMSETFCGLIEKKTIVSKTNQISLRFFSDNSVQKTGFELRFTKELNECA 481

  Fly   960 TQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECI 1024
            |..:.|.|.|:||:||::|:||:|:.|.|:...|:..|||.::..||:|:||:||||||..|.||
Worm   482 TDKNICHHYCVNTVGGFKCACRVGYSLSSNGFSCDSTCGGYLKASNGSISSPNFPEMYPNSKTCI 546

  Fly  1025 WEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSES 1089
            |||.||..:.|.||||.|::||   .:::|.||    |.|:|::. |..|.:..:.:   .|:..
Worm   547 WEIEAPDGYHIFLNFTKFNVEG---MKTECAYD----YVKIGDSE-KLCGEYHEALL---FTTPR 600

  Fly  1090 NALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCK 1154
            |.:|:||.||.|::|.||.|.|..|.|||..:|.||:|.|:|.:|||:|.|:.||.:.|:.|:||
Worm   601 NRVRIEFSSDSSVERDGFFANFIADFDECQNDNAGCEHTCQNRLGSYVCTCNPGYILAEDKHNCK 665

  Fly  1155 EGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVY 1219
            ||.|.:|::||.|.|.|||||:.||...:|.|||:||||||:.|.|:.|.||.|.:|.||.|:||
Worm   666 EGSCFFEVNAPAGDINSPNYPNDYPKGQNCSWHFVTTPGHRLMLTFSSFQVEEHAQCKYDAVSVY 730

  Fly  1220 DGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQF 1284
            ||...|:.:.|.|||...|..:.|:||::|:...:|.:..:.||.|.:::.|||.|.|.|.....
Worm   731 DGGDGSAQLAGVFCGLAPPPLLLSSSNELYLTFSSDASVSRRGFQAHYTSLCGGRLTAESTPGHI 795

  Fly  1285 YSHARFGNQDYDDGMDCEWTIAA--PDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYG 1347
            ||||.|.:..|....||.|.:.|  |... |::.|.||:|||.|.|.:||::::.         |
Worm   796 YSHATFSDSKYGKNQDCSWIVRAKSPGRG-VRIQFSTFNIESEEGCQYDYIEIYD---------G 850

  Fly  1348 P------MYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAVPNS 1394
            |      :.|::||:..|:.|.|....||:...||.:...|||.|.|...|.|
Worm   851 PEATLERLVGRFCGDTSPEVITSTGPELLLIMHTDNAEEEKGFVAEYREAPRS 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	133/200 (67%)
		Astacin	527..721	CDD:279708	127/193 (66%)
		CUB	723..836	CDD:294042	32/118 (27%)
		CUB	840..951	CDD:278839	42/115 (37%)
		FXa_inhibition	958..993	CDD:291342	15/34 (44%)
		CUB	997..1111	CDD:278839	50/113 (44%)
		FXa_inhibition	1118..1153	CDD:291342	16/34 (47%)
		CUB	1158..1267	CDD:278839	51/108 (47%)
		CUB	1271..1390	CDD:238001	45/126 (36%)
nas-39	NP_001360030.1	ZnMc_BMP1_TLD	48..247	CDD:239808	133/200 (67%)
		CUB	268..343	CDD:214483	21/76 (28%)
		CUB	359..474	CDD:238001	42/116 (36%)
		FXa_inhibition	480..515	CDD:373209	15/34 (44%)
		CUB	519..622	CDD:366096	50/113 (44%)
		FXa_inhibition	629..664	CDD:373209	16/34 (47%)
		CUB	669..780	CDD:238001	51/110 (46%)
		CUB	782..898	CDD:238001	44/125 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I982
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49202
Inparanoid	1	1.050	761	1.000	Inparanoid score	I278
Isobase	1	0.950	-	0	Normalized mean entropy	S3510
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		otm14446
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	LDO	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810