DRSC/TRiP Functional Genomics Resources

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Protein Alignment tok and Cubn

DIOPT Version :9

Sequence 1:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster


Alignment Length:1692 Identity:356/1692 - (21%)
Similarity:567/1692 - (33%) Gaps:547/1692 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 DMDPCKAGG-----FMGDI----ALPEGDSGPVVAHTPIDDEEQERQEVEQLLADSPSPVHDPPS 201
            |..|||.||     ..||:    .|| |..|.:.        |........:|:.....:..||.
  Fly   470 DQHPCKNGGRCRPTTSGDLFVCQCLP-GYRGRLC--------ETRFSSCNGMLSAQSGRLRYPPE 525

  Fly   202 VSGAANSGPTKF----------NATF-QLDLEKLKQEVYHEGLQVEE--EGLTDIIRK--KTKLP 251
            .:|..::....:          |.|| ..|:|. ..|...:.||:.:  .....||.:  ...||
  Fly   526 GTGYEHNAQCAWVIRTNESLVVNVTFNSFDVED-STECRFDWLQINDGRSAAAQIIGRYCGNHLP 589

  Fly   252 SSGPVNLKAGQSQSQSQSANEPVKPGSE--------------------------SPSDYAQASSY 290
            ..|.:.....|.....:|.|...|.|.:                          ||.:|.:....
  Fly   590 HGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGSPGNYPKNRDC 654

  Fly   291 KNEVLPPSEQRIHTDKPARLTLAEIGPKFSNKTQSLHRNVDTRKIQSDNKDIEDD-SGN---NFV 351
            :.:::.|:.:||      :||.      ||.:.:. |.|.:     .|...|:|. ||.   .:.
  Fly   655 RWQLVAPTTKRI------KLTF------FSLQLEQ-HANCN-----FDYVLIKDSISGRELAKYC 701

  Fly   352 AERRPSQ-IVPTSLPEQRSTPAHVYSNAGGN--GMQLDDEVDFLHSR-----GVVRRRHRRGPKQ 408
            ....|:. ::||.|.|     .|.:|:|.|:  |.||...|:   .|     ||...:.....:.
  Fly   702 TTGAPAPLLLPTHLAE-----IHFHSDAEGSDTGFQLHYSVE---ERVPGCGGVYTAKEGTISES 758

  Fly   409 RRSNQ-----------HLE--HEVKLQRLREELSRPV--IEAHHHQSHHQKQAQH--------RQ 450
            ..:|.           ||.  .:|.:|..|.||. |:  :|............|.        |.
  Fly   759 STANTEPGGVSCEYEIHLAVGEQVVIQFARLELD-PLDCLEVLDITDEGGSILQEKICGSDASRL 822

  Fly   451 HHQSHHRKKHRRQQQHHRRRGQSTTQY-------VNH------SP--PGFNQSQQAQQQSVP--- 497
            :..:...:.:|.:.:.:.|.|.....|       :|:      ||  |...:|.:....::.   
  Fly   823 NPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTAT 887

  Fly   498 ---------EMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLA 553
                     :..|...|:..|:..      ..:|... ||.|  .:..:|.|.:.|         
  Fly   888 NTVISLKRIDFQLTNGESDDDDND------ECLTTNL-RIND--GLNRKILGPYCG--------- 934

  Fly   554 MRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNG----PQAISIG---------RN 605
                :|.....||.     ..||:...:     .:.|...|.|    .:|::.|         |:
  Fly   935 ----KNQPEENFVS-----ETNYLQLHL-----STDVDSMGRGFKFEYRALATGNDKCGGVHTRS 985

  Fly   606 CDKFGIVVHE---LGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLS-PDEVDSLGMAYD 666
            .|...:.||:   .|....:|           |::...|  |....::|..| .:.||.:   ||
  Fly   986 GDHIRLPVHDDSYAGEATCYW-----------VIMAPAN--KAIRLHWNSFSLENAVDCI---YD 1034

  Fly   667 ----YDSIMHYARNTFSK--GTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQA----NLLYKC- 720
                |||:.....:..||  ..|....:|.::....|    |.:.....|.:::    :|.|.. 
  Fly  1035 YLEIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHSR----QLVLKFVSDYSESDGGFDLTYTFE 1095

  Fly   721 --PKCGRTFQESSGIFAS---PSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCE 780
              .|||.....|||...|   |::|:||.      .|:|.:|.|....:|:::||..:.:|.||.
  Fly  1096 DRAKCGGHIHASSGELTSPEYPANYSAGL------DCDWHLTGTIDHLLEIQVENFELEQSPNCS 1154

  Fly   781 TDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVV---CGG 842
            .||||:|:|....|||||||||:.....|...|..|.|.......|.| |||:..:.:.   |||
  Fly  1155 ADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAING-RGFRLRWRIFAFGCGG 1218

  Fly   843 ELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDG-- 905
            .|..:  :|.:.||.||..|.....|.|:|::.....::|..:..|:|...:|.||.|::..|  
  Fly  1219 SLRSN--MGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIK 1281

  Fly   906 -PGQDA------------PLI--------------------GVFCGYKP---------------- 921
             |.|..            |||                    |....||.                
  Fly  1282 LPNQSPCKVLCKDDDLHNPLIQLENNKGTIVFDSDASNTFRGFRISYKANCIRNLTATTGTIESL 1346

  Fly   922 ----------PPNMK-----SSGNSMYVKFVS---------DTSVQKAGFSAVFMKEVDECET-Q 961
                      |.|..     ..||.:.|: ||         .|:....|...|..:.|.|..| |
  Fly  1347 NYMEPFWETIPINCSWTIRAPKGNRVLVE-VSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQ 1410

  Fly   962 NHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWE 1026
            ......|.:..:..   :..:.|:|......|.:...|..    |...||::|:|||...||.|.
  Fly  1411 AMNISGEVLTVVHN---ASNVNFQLDYRIDGCMEELRGTF----GFFQSPNYPKMYPNNLECYWL 1468

  Fly  1027 IVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNA 1091
            |.......|.|...:.|||    ...:|..|::||.:.  :|.::.....|||:.....||..:.
  Fly  1469 ITVEQDSAIELTINNIDLE----DSPNCTKDALTVSNH--KNSVEVHERHCGSTTKLVITSSGHR 1527

  Fly  1092 LRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEG 1156
            |.:.|.||.|....||.|.:.|....|    ||                                
  Fly  1528 LHVRFISDNSHNGLGFEATYRTVKATC----GG-------------------------------- 1556

  Fly  1157 ECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYD- 1220
                :::|..|.|.|||||.:||.::.|.|....:..|:|.....:.::||..:|.:|.:..|| 
  Fly  1557 ----KLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDL 1617

  Fly  1221 -GESESSSVLGRFCGDKIPFP--ISSTSNQMYMVLKTDKNKQKNGFTASHSTACG---------- 1272
             .:......|.:.|||:....  :||:||...:...:|.:..|.||......:||          
  Fly  1618 TEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFHESCGQTIIVDETMF 1682

  Fly  1273 GYLRATSQ--------------------------------------------------------- 1280
            .|::.:.|                                                         
  Fly  1683 DYIQMSRQAARNESCLWVFQAVEPNKRIIFTPTHVKLREDANQQYPTEGDCLNVGVKIYEGTEPQ 1747

  Fly  1281 ------------------------------VQQFYSH----------------ARFGN----QDY 1295
                                          |::|..|                .:|.:    ..|
  Fly  1748 GTPRLKFCRSHPPALISNGQALTVSVPLQLVEEFQGHYMTMDTSCGSIYNALSGKFTSPYYPASY 1812

  Fly  1296 DDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQ 1360
            ...::|.|.:.|...:.:.|...:.|:|.||:|..||::|..:     .:.|.:.|.||||.:|.
  Fly  1813 PPNIECLWLLEASMGNSLSLTLESMDLEKSESCNRDYLEVREE-----SESGQLIGVYCGNEVPG 1872

  Fly  1361 DINSMTHSLLVRFKTDGSVPMKGFSASYVAVPNSGEYDHSDE------DVEN-SYSSEMVTPFPG 1418
            .|:| ..::.::||:|.....:||.|||       .|:|.:|      .:|: .:.|:...|.|.
  Fly  1873 VIHS-RGAIWMKFKSDDDNVGEGFMASY-------NYEHHNELNGTEGTIESPHFPSKFQDPVPY 1929

  Fly  1419 S------------LKSIYIEDTQEE----TDEYSD--------------FSGNQLVFNGQYRGRY 1453
            |            :..:|:.|..:.    .|.|||              .|...:|:....||.:
  Fly  1930 SWRITVDKEYVVAISLLYLRDLDQPHLNFYDGYSDIGARIEVTDPDETIISSTNVVYFTSNRGPF 1994

  Fly  1454 SL 1455
            .|
  Fly  1995 KL 1996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808 44/230 (19%)
Astacin 527..721 CDD:279708 43/223 (19%)
CUB 723..836 CDD:294042 44/115 (38%)
CUB 840..951 CDD:278839 38/185 (21%)
FXa_inhibition 958..993 CDD:291342 5/35 (14%)
CUB 997..1111 CDD:278839 35/113 (31%)
FXa_inhibition 1118..1153 CDD:291342 3/34 (9%)
CUB 1158..1267 CDD:278839 32/112 (29%)
CUB 1271..1390 CDD:238001 38/235 (16%)
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011 12/41 (29%)
CUB 509..622 CDD:238001 22/113 (19%)
CUB 627..737 CDD:238001 29/132 (22%)
CUB 744..849 CDD:294042 17/105 (16%)
CUB 853..970 CDD:238001 23/148 (16%)
CUB 978..1094 CDD:238001 27/135 (20%)
CUB 1100..1211 CDD:238001 44/117 (38%)
CUB 1216..1330 CDD:238001 28/115 (24%)
CUB 1446..1549 CDD:238001 34/112 (30%)
CUB 1554..1667 CDD:238001 35/152 (23%)
CUB 1792..1899 CDD:238001 29/112 (26%)
CUB 1910..1998 CDD:294042 16/87 (18%)
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45444843
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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