DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and Cdcp2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	XP_038967409.1	Gene:	Cdcp2 / 298306	RGDID:	1563467	Length:	566	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	144/463 - (31%)
Similarity:	208/463 - (44%)	Gaps:	99/463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   812 ESSR--MLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITV 874
            |:||  ..||.:.....:....|.....|.|||.||...  |...|||:|..|..|.||.|.|.|
  Rat    26 EASRRQSCLTRIQNPGADSQPSFSLASGVKCGGVLSAPS--GNFSSPNFPSLYPYNTECSWLIVV 88

  Fly   875 PESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQD-APLIGVFCGYKPPPNMKSSGNSMYVKFVS 938
            .|...|.|.|.:|::|.||:|.:|::|:.:|..:| ..|:|.|||..|||...||.:.|.|.|.|
  Rat    89 AEGSSVLLTFHTFDLEYHDTCGFDFLEIYNGASRDKGNLLGRFCGQAPPPPFTSSWHVMSVVFHS 153

  Fly   939 DTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEY 1003
            |..|...||||                         ||:                :|.||||:..
  Rat   154 DKHVASRGFSA-------------------------GYQ----------------KDVCGGVLTG 177

  Fly  1004 PNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGEN 1068
            .:|.::||.:|..||...||.|.|.|.....:.|.|..|.:||:    .:|.||.|||   ||..
  Rat   178 LSGILSSPEYPNNYPNNVECHWLIRASGPATVKLVFVDFQVEGS----EECMYDHVTV---LGAP 235

  Fly  1069 RLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTI 1133
            .......:|||:.|||..|..:.|::.|.||.:|...||.|.:|:
  Rat   236 GPAHGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAHYFS-------------------- 280

  Fly  1134 GSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKL 1198
                                  |||:...:|..|...||.||.:||.|..|.|.....||:|:|:
  Rat   281 ----------------------GECQEVFTAVRGNFSSPQYPGAYPNNIRCHWTIRLPPGYRVKV 323

  Fly  1199 IFNEFDVES----HQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQ 1259
            ...:..:|.    .:.|.:|::|.:||.||.:.:||::||..:|.|::|:.||:.::|.||::..
  Rat   324 FVLDLGLEEPNSLTRTCDFDHLAAFDGASEEAKLLGKWCGHHLPPPVTSSHNQLLLLLHTDRSTS 388

  Fly  1260 KNGFTASH 1267
            ..||:.::
  Rat   389 GRGFSVAY 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		Astacin	527..721	CDD:279708
		CUB	723..836	CDD:294042	6/25 (24%)
		CUB	840..951	CDD:278839	50/111 (45%)
		FXa_inhibition	958..993	CDD:291342	2/34 (6%)
		CUB	997..1111	CDD:278839	43/113 (38%)
		FXa_inhibition	1118..1153	CDD:291342	0/34 (0%)
		CUB	1158..1267	CDD:278839	38/112 (34%)
		CUB	1271..1390	CDD:238001
Cdcp2	XP_038967409.1	CUB	56..167	CDD:238001	51/137 (37%)
		CUB	171..280	CDD:238001	43/115 (37%)
		CUB	283..396	CDD:238001	38/112 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000