DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and Astl

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001099974.1	Gene:	Astl / 296129	RGDID:	1562279	Length:	436	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	101/308 - (32%)
Similarity:	143/308 - (46%)	Gaps:	65/308 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 PPGFNQ--SQQAQQQSVPEMD--LLKAETSKDEEPLRHRVAR-------AVTAKKERIWDYGV-- 533
            |.||..  |:.:|.:.:|.::  |:..||.:....:...:.|       :||..|   |..||
  Rat    39 PEGFTPEGSRVSQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNK---WPKGVDG 100

  Fly   534 ---IPYEIDGNFSGIHKALFKLAMRHWENSTCIKFV----ERDPEIHPNYIVFTVRSCGCCSFVG 591
               ||:.:...:....:.:...|...:|..|||:||    :||       .|..:...||.|.||
  Rat   101 IVEIPFLLSSKYDEPSRQVIMEAFAEFERFTCIRFVAYRGQRD-------FVSILPMAGCFSGVG 158

  Fly   592 KRGNGPQAISIGRNC--DKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNF---- 650
            :.| |.|.:|:...|  ...|||:|||.||:||||||:|.||::::.:..|.|:.|.:.||
  Rat   159 RSG-GMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHSRADRDRYIRVNWNEILPGFEINFIKSR 222

  Fly   651 --NMLSPDEVDSLGMAYDYDSIMHYARNTFS-KGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIA 712
              |||:|         |||.|:|||.|..|| :|.  .||:|:   ......||||..||..||.
  Rat   223 NSNMLAP---------YDYSSVMHYGRFAFSWRGQ--PTIIPL---WTSSVHIGQRWNLSTSDIT 273

  Fly   713 QANLLYKCPKC-----GRTFQ-ESSGIFASP---SHY--TAGALSNET 749
            :...||.|...     ||.|: .|.|...:|   ||.  ...|||.|:
  Rat   274 RVCRLYSCSPSVPDSHGRGFEAPSDGRSPTPASISHLQRLLEALSEES 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	78/218 (36%)
		Astacin	527..721	CDD:279708	75/211 (36%)
		CUB	723..836	CDD:294042	12/38 (32%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
Astl	NP_001099974.1	Astacin	92..283	CDD:279708	77/215 (36%)
		ZnMc	99..281	CDD:294052	72/203 (35%)
		ImpA_N	<305..420	CDD:303075	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810