DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tok and Pcolce

DIOPT Version :9

Sequence 1:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_062110.1 Gene:Pcolce / 29569 RGDID:3270 Length:468 Species:Rattus norvegicus


Alignment Length:452 Identity:127/452 - (28%)
Similarity:190/452 - (42%) Gaps:113/452 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   839 VCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVR 903
            :|||:::.:.  |.:.|..:|..|.|||:|:|.|||||...|:|.|:.|::|.|.||.||.:||.
  Rat    35 LCGGDVTGES--GYVASEGFPNLYPPNKKCIWTITVPEGQTVSLSFRVFDMELHPSCRYDALEVF 97

  Fly   904 DGPGQDAPLIGVFCG-YKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEH 967
            .|.|.....:|.||| ::|.| :.:.||.:.::..:|......||...:....      ..|.||
  Rat    98 AGSGTSGQRLGRFCGTFRPAP-VVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA------TSGTEH 155

  Fly   968 ECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEM-YPLLKECIWEIVAPP 1031
            :                           .|||.:|...||:|:|::||. ||....|.|.|:||.
  Rat   156 Q---------------------------FCGGRMEKAQGTLTTPNWPESDYPPGISCSWHIIAPS 193

  Fly  1032 KHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEF 1096
            ...|.|.|..||:|...:    |.||||:|::....:..||:|.|||...|...:||.|.|.::|
  Rat   194 NQVIMLTFGKFDVEPDTY----CRYDSVSVFNGAVSDDSKRLGKFCGDKAPSPISSEGNELLVQF 254

  Fly  1097 HSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEG----- 1156
            .||.|:...||:|.:.| :...||..                     .|....|.|.:.|     
  Rat   255 VSDLSVTADGFSASYRT-LPRDAVEK---------------------ESAPSPGEDAQHGPQSRS 297

  Fly  1157 --------------ECKYE-ISAPFG---TIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEF 1203
                          :.|.: :..|.|   |..:|..||:  |:..|...:     .|...:.:.|
  Rat   298 DPKTGTGPKVKPPSKPKVQPVEKPEGSPATQATPVAPDA--PSITCPKQY-----KRSGTLQSNF 355

  Fly  1204 DVESHQECTYDNV------AVYDGESE----SSSVLGRF-CGD-KIPFPISSTSNQMYMVLK 1253
                   |:...|      |:..|..|    :.|:||.: .|| .:|.|.|.||.:.|:..|
  Rat   356 -------CSSSLVVTGTVKAMVRGPGEGLTVTVSLLGVYKTGDLDLPSPASGTSLKFYVPCK 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808
Astacin 527..721 CDD:279708
CUB 723..836 CDD:294042
CUB 840..951 CDD:278839 42/111 (38%)
FXa_inhibition 958..993 CDD:291342 3/34 (9%)
CUB 997..1111 CDD:278839 47/114 (41%)
FXa_inhibition 1118..1153 CDD:291342 4/34 (12%)
CUB 1158..1267 CDD:278839 28/112 (25%)
CUB 1271..1390 CDD:238001
PcolceNP_062110.1 CUB 36..146 CDD:238001 42/112 (38%)
CUB 158..271 CDD:238001 47/116 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..341 15/93 (16%)
NTR_PCOLCE 334..460 CDD:239631 23/91 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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