Protein Alignment tok and Kremen2

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_001382036.1
• Gene: Kremen2 / 287102
• RGDID: 1310795
• Length: 462
• Species: Rattus norvegicus
• Alignment Length: 211
• Identity: 50/211 - (23%)
• Similarity: 86/211 - (40%)
• Gaps: 28/211 - (13%)

  Fly  1073 IGTFCGSSIPP-------TATSESNALRLEFHSDKSIQRSGFA---AVFFTDIDECAVNNGGCQH 1127
            :|.|..|..||       |:|..:..:.|.|...|..|.:|..   |.|.....:.|........
  Rat   124 LGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRPAPAT 188

  Fly  1128 ECRNTIGSYICMCHNGYSMHENG----HDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHF 1188
            :|     ..||..|.|.....:|    ::...|.|:...:||.|.|:||::||.|.|:.:|.| .
  Rat   189 DC-----DQICFGHPGQLCGGDGRLGIYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-V 247

  Fly  1189 ITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCG--DKIPFPISSTSNQMYMV 1251
            :...|..::|.|..|::...:    |.:.:.|  :.|.::|..|.|  ...|.|:...:..:.:.
  Rat   248 LGQLGAVLELTFRLFELADSR----DRLELRD--ASSGNLLRAFDGAHPPPPGPLHLRTAALLLT 306

  Fly  1252 LKTDKNKQKNGFTASH 1267
            .::|......||..::
  Rat   307 FRSDARGHAQGFALTY 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		CUB	723..836	CDD:412131
		CUB	840..951	CDD:395345
		FXa_inhibition	958..993	CDD:464251
		CUB	997..1111	CDD:395345	13/47 (28%)
		FXa_inhibition	1118..1153	CDD:464251	7/38 (18%)
		CUB	1158..1267	CDD:395345	28/110 (25%)
		CUB	1271..1390	CDD:238001
Kremen2	NP_001382036.1	KR	33..118	CDD:214527
		WSC	123..204	CDD:460348	20/84 (24%)
		CUB	218..323	CDD:238001	28/112 (25%)