DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and PCOLCE2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_037495.1	Gene:	PCOLCE2 / 26577	HGNCID:	8739	Length:	415	Species:	Homo sapiens

Alignment Length:	312	Identity:	100/312 - (32%)
Similarity:	145/312 - (46%)	Gaps:	59/312 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 CGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRD 904
            |||.|:.:.  |.:.|..:|..|.||.:|.|||||||...|.|.|:..::|:.:.|.||:|:|.:
Human    33 CGGILTGES--GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYN 95

  Fly   905 GPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHEC 969
            |.. :...||.|||...|..:.||||.|.|:.:||.:....||.|:|    ...|....|.::
Human    96 GHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF----SAAEPNERGDQY-- 153

  Fly   970 INTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEM-YPLLKECIWEIVAPPKH 1033
                                       |||:::.|:|:..:|::|:. ||....|:|.||||...
Human   154 ---------------------------CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQ 191

  Fly  1034 RISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHS 1098
            .|.|.|..||:|    :.:.|.||.|.|::....|..:|||.:||.|.|....||.|.|.::|.|
Human   192 LIELKFEKFDVE----RDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLS 252

  Fly  1099 DKSIQRSGFAAVFF-------TDIDE-----CAVNNG------GCQHECRNT 1132
            |.|:...||...:.       |..::     ..|..|      .||.:||.|
Human   253 DLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRT 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808
		Astacin	527..721	CDD:279708
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839	45/110 (41%)
		FXa_inhibition	958..993	CDD:291342	2/34 (6%)
		CUB	997..1111	CDD:278839	44/114 (39%)
		FXa_inhibition	1118..1153	CDD:291342	7/21 (33%)
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
PCOLCE2	NP_037495.1	CUB	33..143	CDD:238001	46/116 (40%)
		CUB	154..267	CDD:238001	44/116 (38%)
		NTR_PCOLCE	292..415	CDD:239631	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910