Protein Alignment tok and Tll2

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_036034.1
• Gene: Tll2 / 24087
• MGIID: 1346044
• Length: 1012
• Species: Mus musculus
• Alignment Length: 978
• Identity: 481/978 - (49%)
• Similarity: 646/978 - (66%)
• Gaps: 46/978 - (4%)

  Fly   416 EHEVKLQRL--REELSRPVIEAHHHQSHHQKQAQHRQHHQSHHRKKHRRQQQHHRRRGQSTTQYV 478
            |.::||..:  .|:.::|.|:...|.:...::...|..:.:    ......|..|:.|:..|.::
Mouse    67 EDDLKLFHIDKAEDWTKPSIDKPGHDTGGLEETSARWPNDT----ASNASIQAPRKDGKDATTFL 127

  Fly   479 NHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFS 543
            .:  ||.:.:                 |:|   ....||.||.|::.||||..|||||.|.|||:
Mouse   128 PN--PGTSNT-----------------TAK---TFSARVRRATTSRTERIWPGGVIPYVIGGNFT 170

  Fly   544 GIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDK 608
            |..:|:||.||||||..||:.||||..|  .::|||:.|:|||||:||:||.||||||||:||||
Mouse   171 GTQRAIFKQAMRHWEKHTCVTFVERTDE--ESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDK 233

  Fly   609 FGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHY 673
            ||||.||||||||||||||||||::||.|...||..||:|||..:...||.|||..||:||||||
Mouse   234 FGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHY 298

  Fly   674 ARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS 738
            ||||||:|.:||||||.......||.||||:||||||||||..|||||.||.|.|:::|.|::|.
Mouse   299 ARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPG 363

  Fly   739 HYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGK 803
             :..|..|  ..||.|||:.|.||::.|...:|::|||..|..||:||||||:.|:||:|||||.
Mouse   364 -FPNGYPS--YSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGD 425

  Fly   804 VDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKEC 868
            ...|.:.:..||:.:.:.::....| :||.|.::.:|||:::.|  .|:::|||||.||.|:|||
Mouse   426 KIPESLVSSDSRLWVEFRSSSSSLG-KGFFAVYEAMCGGDITKD--AGQIQSPNYPDDYRPSKEC 487

  Fly   869 VWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMY 933
            ||:||||:.:.|.|.|||||:|.||||.|||:|:||||.:|:.|||.||||:.|..:|||.|.::
Mouse   488 VWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSANRLW 552

  Fly   934 VKFVSDTSVQKAGFSAVFMKEVDECETQNH-GCEHECINTLGGYECSCRIGFELHSDKKHCEDAC 997
            ||||||.|:.||||:|.|.||||||...:| |||..|:||||.|.|:|..|:||.:|||.||.||
Mouse   553 VKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAADKKTCEVAC 617

  Fly   998 GGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVY 1062
            ||.|...|||||||.:|:.||..|.|:|::|||.::||||.|..|:|||    ...|.||.|.|.
Mouse   618 GGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEG----NDVCKYDFVEVR 678

  Fly  1063 SKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQH 1127
            |.|..: .|..|.||||..|...||:||.:|:||.||.::.:.||.|.||:|.||||.:|||||.
Mouse   679 SGLSPD-AKLHGKFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQQ 742

  Fly  1128 ECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTP 1192
            ||.||.|||:|.|.|||.:|||||||||..|.|:||:..||:.|||:||.||...:|.|:..:|.
Mouse   743 ECVNTFGSYLCRCRNGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTA 807

  Fly  1193 GHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKN 1257
            |||:|:.|:||::|.||||.||::.:|||....:.:||||||.|.|.|:.:|.:.:::...:|.:
Mouse   808 GHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVATGSSLFLRFYSDAS 872

  Fly  1258 KQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDI 1322
            .|:.||.|.|||.|||.|:|..|.::.||||:||:.:|.....|:|.|.|.|...|:|||.||::
Mouse   873 VQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEV 937

  Fly  1323 ESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSAS 1387
            |...:|.:|:::.:    |.|....|..|::||:...::|.|...||::||.||.::..|||.|.
Mouse   938 EEEADCGYDFMEAY----DGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFHTDDTINKKGFHAR 998

  Fly  1388 YVA 1390
            |.:
Mouse   999 YTS 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	134/200 (67%)
		CUB	723..836	CDD:412131	46/112 (41%)
		CUB	840..951	CDD:395345	67/110 (61%)
		FXa_inhibition	958..993	CDD:464251	19/35 (54%)
		CUB	997..1111	CDD:395345	55/113 (49%)
		FXa_inhibition	1118..1153	CDD:464251	24/34 (71%)
		CUB	1158..1267	CDD:395345	48/108 (44%)
		CUB	1271..1390	CDD:238001	46/118 (39%)
Tll2	NP_036034.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..135		10/57 (18%)
		ZnMc_BMP1_TLD	147..346	CDD:239808	134/200 (67%)
		CUB	348..457	CDD:395345	46/112 (41%)
		CUB	461..570	CDD:395345	67/110 (61%)
		FXa_inhibition	577..613	CDD:464251	19/35 (54%)
		CUB	617..726	CDD:395345	55/113 (49%)
		FXa_inhibition	733..768	CDD:464251	24/34 (71%)
		CUB	773..882	CDD:395345	48/108 (44%)
		CUB	886..999	CDD:395345	45/116 (39%)