DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and Tll2

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_036034.1	Gene:	Tll2 / 24087	MGIID:	1346044	Length:	1012	Species:	Mus musculus

Alignment Length:	978	Identity:	481/978 - (49%)
Similarity:	646/978 - (66%)	Gaps:	46/978 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 EHEVKLQRL--REELSRPVIEAHHHQSHHQKQAQHRQHHQSHHRKKHRRQQQHHRRRGQSTTQYV 478
            |.::||..:  .|:.::|.|:...|.:...::...|..:.:    ......|..|:.|:..|.::
Mouse    67 EDDLKLFHIDKAEDWTKPSIDKPGHDTGGLEETSARWPNDT----ASNASIQAPRKDGKDATTFL 127

  Fly   479 NHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFS 543
            .:  ||.:.:                 |:|   ....||.||.|::.||||..|||||.|.|||:
Mouse   128 PN--PGTSNT-----------------TAK---TFSARVRRATTSRTERIWPGGVIPYVIGGNFT 170

  Fly   544 GIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDK 608
            |..:|:||.||||||..||:.||||..|  .::|||:.|:|||||:||:||.||||||||:||||
Mouse   171 GTQRAIFKQAMRHWEKHTCVTFVERTDE--ESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDK 233

  Fly   609 FGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHY 673
            ||||.||||||||||||||||||::||.|...||..||:|||..:...||.|||..||:||||||
Mouse   234 FGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHY 298

  Fly   674 ARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS 738
            ||||||:|.:||||||.......||.||||:||||||||||..|||||.||.|.|:::|.|::|.
Mouse   299 ARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPG 363

  Fly   739 HYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGK 803
             :..|..|  ..||.|||:.|.||::.|...:|::|||..|..||:||||||:.|:||:|||||.
Mouse   364 -FPNGYPS--YSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGD 425

  Fly   804 VDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKEC 868
            ...|.:.:..||:.:.:.::....| :||.|.::.:|||:::.|  .|:::|||||.||.|:|||
Mouse   426 KIPESLVSSDSRLWVEFRSSSSSLG-KGFFAVYEAMCGGDITKD--AGQIQSPNYPDDYRPSKEC 487

  Fly   869 VWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMY 933
            ||:||||:.:.|.|.|||||:|.||||.|||:|:||||.:|:.|||.||||:.|..:|||.|.::
Mouse   488 VWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSANRLW 552

  Fly   934 VKFVSDTSVQKAGFSAVFMKEVDECETQNH-GCEHECINTLGGYECSCRIGFELHSDKKHCEDAC 997
            ||||||.|:.||||:|.|.||||||...:| |||..|:||||.|.|:|..|:||.:|||.||.||
Mouse   553 VKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAADKKTCEVAC 617

  Fly   998 GGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVY 1062
            ||.|...|||||||.:|:.||..|.|:|::|||.::||||.|..|:|||    ...|.||.|.|.
Mouse   618 GGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEG----NDVCKYDFVEVR 678

  Fly  1063 SKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQH 1127
            |.|..: .|..|.||||..|...||:||.:|:||.||.::.:.||.|.||:|.||||.:|||||.
Mouse   679 SGLSPD-AKLHGKFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQQ 742

  Fly  1128 ECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTP 1192
            ||.||.|||:|.|.|||.:|||||||||..|.|:||:..||:.|||:||.||...:|.|:..:|.
Mouse   743 ECVNTFGSYLCRCRNGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTA 807

  Fly  1193 GHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKN 1257
            |||:|:.|:||::|.||||.||::.:|||....:.:||||||.|.|.|:.:|.:.:::...:|.:
Mouse   808 GHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVATGSSLFLRFYSDAS 872

  Fly  1258 KQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDI 1322
            .|:.||.|.|||.|||.|:|..|.::.||||:||:.:|.....|:|.|.|.|...|:|||.||::
Mouse   873 VQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEV 937

  Fly  1323 ESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSAS 1387
            |...:|.:|:::.:    |.|....|..|::||:...::|.|...||::||.||.::..|||.|.
Mouse   938 EEEADCGYDFMEAY----DGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFHTDDTINKKGFHAR 998

  Fly  1388 YVA 1390
            |.:
Mouse   999 YTS 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	134/200 (67%)
		Astacin	527..721	CDD:279708	131/193 (68%)
		CUB	723..836	CDD:294042	46/112 (41%)
		CUB	840..951	CDD:278839	67/110 (61%)
		FXa_inhibition	958..993	CDD:291342	19/35 (54%)
		CUB	997..1111	CDD:278839	55/113 (49%)
		FXa_inhibition	1118..1153	CDD:291342	24/34 (71%)
		CUB	1158..1267	CDD:278839	48/108 (44%)
		CUB	1271..1390	CDD:238001	46/118 (39%)
Tll2	NP_036034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..135		10/57 (18%)
		ZnMc_BMP1_TLD	147..346	CDD:239808	134/200 (67%)
		Astacin	154..347	CDD:279708	132/194 (68%)
		CUB	348..457	CDD:278839	46/112 (41%)
		CUB	461..570	CDD:278839	67/110 (61%)
		FXa_inhibition	581..613	CDD:291342	18/31 (58%)
		CUB	617..726	CDD:278839	55/113 (49%)
		FXa_inhibition	733..768	CDD:291342	24/34 (71%)
		CUB	773..882	CDD:278839	48/108 (44%)
		CUB	886..999	CDD:278839	45/116 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1591
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1014	1.000	Inparanoid score	I286
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8692
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900