DRSC/TRiP Functional Genomics Resources

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Protein Alignment tok and clec-9

DIOPT Version :10

Sequence 1:NP_476879.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_507227.2 Gene:clec-9 / 190567 WormBaseID:WBGene00013493 Length:414 Species:Caenorhabditis elegans


Alignment Length:479 Identity:95/479 - (19%)
Similarity:153/479 - (31%) Gaps:172/479 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   860 LDYLPN--------KECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVF 916
            |.|.||        ..|.       ||...|......::|.  .|..:|    |....:..:|:|
 Worm    34 LRYFPNARNHRAAENSCF-------SYDATLVTVKNSIDNR--AVSTFV----GNAASSIWMGLF 85

  Fly   917 C------------------GY----KPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECE 959
            |                  ||    ...|.:: ||..:|:..:..:|.:  .:|.       .|:
 Worm    86 CFNMDVTNCLWDDGNGTAQGYNNFMNGSPQIE-SGKCVYISLMGSSSGR--WYSG-------NCD 140

  Fly   960 TQNHG--C------EHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPS---- 1012
            ..:..  |      |.:|.|...|:..|..........:::||:.||.::     :|.||:    
 Worm   141 LDSRPFVCELPITFEDDCSNNYNGFCYSYNPPASFVRAQQNCENQCGSIV-----SILSPNENRY 200

  Fly  1013 ----FP----------------EMYPLLKECIWEI-----VAPPKHRISLNFTHFDLEGTAHQQS 1052
                ||                :.|.......|..     .:|.|:.:::..:..|...:.    
 Worm   201 VGALFPRYESNDMIIGATWTTKDTYSWFDGSPWNFNQINPASPKKNCLAMVTSLNDASASG---- 261

  Fly  1053 DCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTAT-SESNALRLEFHSDKSIQRSGFAAVFFTDID 1116
              .:..:..||..|....:..|..|....|.|.| :.||.             ||          
 Worm   262 --SWYPIVCYSAYGYLCKRPAGVQCPQYPPVTVTPAPSNP-------------SG---------- 301

  Fly  1117 ECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPN 1181
                        |.:||.|                              ||||.|||:|.:|...
 Worm   302 ------------CNSTIMS------------------------------FGTITSPNFPMNYNNI 324

  Fly  1182 ADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCG-DKIPFPISSTS 1245
            ..|.:...|...:.:.|.||:|    :.:...|.|.:|||:|..|.|:.::.| .:.||...||.
 Worm   325 TSCNYLLTTLGSYNVMLKFNKF----YTDMKNDFVTLYDGDSTKSPVIAKYSGYYEWPFFNVSTG 385

  Fly  1246 NQMYMVLKTDKNKQKNGFTASHST 1269
            |.|.:..:::......||||..|:
 Worm   386 NSMLVTFRSNSTFGYYGFTAIASS 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_476879.1 ZnMc_BMP1_TLD 520..721 CDD:239808
CUB 723..836 CDD:412131
CUB 840..951 CDD:395345 23/120 (19%)
FXa_inhibition 958..993 CDD:464251 7/42 (17%)
CUB 997..1111 CDD:395345 24/143 (17%)
FXa_inhibition 1118..1153 CDD:464251 4/34 (12%)
CUB 1158..1267 CDD:395345 34/109 (31%)
CUB 1271..1390 CDD:238001
clec-9NP_507227.2 CLECT 22..149 CDD:214480 24/137 (18%)
CLECT 162..277 CDD:214480 19/125 (15%)
CUB 302..409 CDD:238001 38/140 (27%)
Blue background indicates that the domain is not in the aligned region.

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