DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-27

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_493926.2	Gene:	nas-27 / 188809	WormBaseID:	WBGene00003545	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	406	Identity:	105/406 - (25%)
Similarity:	181/406 - (44%)	Gaps:	87/406 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 LRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYI 577
            ::.|..|||..:|.:.|.. .:||..|.||....:.....||:.|...||:.|.| :..::|:..
Worm    51 VKSRARRAVIRQKHKKWKL-PMPYSFDRNFPSRSRQRVLEAMQFWSEKTCVTFHE-NRYVYPHVS 113

  Fly   578 VFTVRSCGCCSFVGKRGN-GPQAISIGRNC-DKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHN 640
            :|  ...||.|||||:.: ..|::|:.|:| |...:|.||:.|.:||:|||.|.||::.:.|:::
Worm   114 IF--EGNGCWSFVGKQPSLREQSLSLERSCTDHTFVVAHEIAHTLGFYHEHARGDRDQFISIDYS 176

  Fly   641 NIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLR 705
            |:.....:.|...|..::|....||:|.|:|||:.:.|:..|....|...:.|..:  .:|.|:|
Worm   177 NVNPNLTFAFAKESEKQLDHQEAAYEYGSVMHYSVDQFAVNTNRPVIYARDQKFAQ--AMGNRMR 239

  Fly   706 LSQGDIAQANLLYKC-PKCGRTFQE-SSGIFASPSH--------------------YTAGALSN- 747
            .:..|:::.|:||.| .:|..|... ..|.:.:||.                    ::.|...|
Worm   240 ATFQDVSRMNVLYNCHERCANTLNRCQQGGYPAPSDCSQCVCPDGFGGNFCETIEAHSVGQKDNS 304

  Fly   748 ---------ET---------------------EHCEWRITATYGERVELKLENMNIFKSNNCETD 782
                     ||                     |||.|.|.|:.|:.:|::::|:....|.:|..:
Worm   305 DCGGVLWASETSQTFYGAVRTRVHSNSVLPTPEHCFWHIRASQGKSIEIQIKNIISPCSMSCSFN 369

  Fly   783 YLEIRDGYFEKSPLIG-RFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSV 846
            .||::...|   .:.| |||  .|:.:....|...:              |::|      |.|:|
Worm   370 ALELKLSNF---TMTGPRFC--CDEHIYNRYSQPKV--------------FQSE------GPLAV 409

  Fly   847 DDAVGRLESPNYPLDY 862
            ..|..|.:..::.::|
Worm   410 IGAYARYDYLDFNIEY 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	66/203 (33%)
		Astacin	527..721	CDD:279708	63/196 (32%)
		CUB	723..836	CDD:294042	30/165 (18%)
		CUB	840..951	CDD:278839	6/23 (26%)
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-27	NP_493926.2	Astacin	65..254	CDD:279708	62/194 (32%)
		ZnMc_astacin_like	70..252	CDD:239807	59/186 (32%)
		CUB	334..410	CDD:294042	24/100 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810