DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-21

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_505907.2	Gene:	nas-21 / 188422	WormBaseID:	WBGene00003540	Length:	380	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	81/374 - (21%)
Similarity:	141/374 - (37%)	Gaps:	68/374 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 LLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEID-GNFSGIHKALFKLAMRHWENSTCIK 564
            :::...|.:.:.|.....:|:....|..|..|.|.|..| ..|....:|....||....|.||||
Worm    28 VMRVGGSPETKRLERSKRQALRMDNEPRWPRGTINYFFDEQRFDENSRATVLRAMEKISNHTCIK 92

  Fly   565 FVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRP 629
            |..:|..|.    :..|...||.:.:|:.|...|.:|...:|...| ...||.||:||.|.|.|.
Worm    93 FSPKDARIK----LRIVSDKGCQAAIGRVGGDQQYLSFPTSCYSVG-SASELIHVIGFLHSHQRA 152

  Fly   630 DREKHVVIEHNNIM--KGQDYNFNMLSPDEVDSLGMA-YDYDSIMHYARNTFSKG---------- 681
            ||::::.:   |:.  :..|:...|.....:|...:. |||.|||.|..:....|
Worm   153 DRDEYLKL---NLQPWRLNDWFQTMQYKKYLDQWWIVPYDYGSIMQYHDSDNEYGPKNSKYFRTM 214

  Fly   682 -----TYLDTIL-------------PIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQ 728
                 :|.|.::             .|..|.|..|..|                 .|.:|....:
Worm   215 GSQIPSYFDYLMINEYYQCSCEGEEQINCKNRGYPNPG-----------------NCSECNCPLE 262

  Fly   729 ESSGIFASPSHYTAG--ALSNETEHCE-------WRITATYGERVELKLENMNIFKSN-NCETDY 783
            .|........:..||  :|.|.|:..:       ..|:|...:.:|:.:..:...:.| .|....
Worm   263 SSEEWKNITLNLDAGYMSLQNGTKLHQIDFVFRYLSISAPANKTIEVDIREITGVECNYGCYIGG 327

  Fly   784 LEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGF 832
            :|::. :.::.....|.|.|.|.|:.::.::..::...|:..::.:..|
Worm   328 IEVKT-HEDRRMTSPRLCCKNDNEIYKSRNNPTIVMAFNSEGLDKYNIF 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	58/232 (25%)
		Astacin	527..721	CDD:279708	56/225 (25%)
		CUB	723..836	CDD:294042	20/120 (17%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-21	NP_505907.2	ZnMc	52..192	CDD:214576	45/147 (31%)
nas-21	NP_505907.2	ZnMc_astacin_like	59..231	CDD:239807	50/179 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810