DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tok and nas-19

DIOPT Version :9

Sequence 1:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_505893.2 Gene:nas-19 / 186926 WormBaseID:WBGene00003538 Length:396 Species:Caenorhabditis elegans


Alignment Length:470 Identity:109/470 - (23%)
Similarity:176/470 - (37%) Gaps:153/470 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   510 EEPLRHRVARAVTAKKERI---WDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPE 571
            ||...|   :.|..:.||:   |.|||:.|......:.| |.:.:.|:.:..|.|||:|.|....
 Worm    31 EESYSH---KRVKRQFERLGTKWSYGVVNYYYADKNNEI-KEMVESAIAYIANHTCIRFNEDQNA 91

  Fly   572 I-------HPNYIVFTVRSCGCCSFVGKRGNGPQAISIG------RNCDKFGIVVHELGHVVGFW 623
            :       ..|::        |.|.||..|.. .:..||      ::||..|.:|||..|.:|.:
 Worm    92 VQRVQIRMQQNWL--------CQSTVGAPGMS-MSKPIGELSMLVQSCDTIGSIVHEFSHSLGRF 147

  Fly   624 HEHTRPDREKHVVIEHNNIMKGQDYNFNMLS---------PDEVDSLGMAYDYDSIMHYARNTFS 679
            ||||||||:                ||..::         |..:.::...:::.|:|.|..:|:.
 Worm   148 HEHTRPDRD----------------NFMKVTTTVHEARPRPSGMTTMYGPFEHGSVMMYHADTYG 196

  Fly   680 KGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS-----H 739
            .|| :|   |::|..::  .:|.| |::..|:.:.|..|.| .|.:..:..:|.:.|||     :
 Worm   197 PGT-MD---PLDMDYKQ--TMGNR-RVTFYDMYKINQYYGC-WCSKQLECKNGGYTSPSDCSRCN 253

  Fly   740 YTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEI--RDGYFEKSPLIGRFCG 802
            ...|...|   .|:.|...:|    ||...| |:::|......|...  .||::.....|   .|
 Worm   254 CPKGFFGN---LCDERQQDSY----ELMAVN-NLWQSITIPFAYKPEPGSDGFYSTFVYI---TG 307

  Fly   803 KVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKE 867
            |.:..:..|              :||.:      ||:|....:|:.                   
 Worm   308 KANSTIEIT--------------LEGLQ------DVICTAGCTVNG------------------- 333

  Fly   868 CVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPN--MKSSGN 930
                        |.:||:      .||.:...|              |.|..|||..  .|||.|
 Worm   334 ------------VEIKFK------EDSKITSPV--------------VCCTDKPPYKNVFKSSHN 366

  Fly   931 SMYVKFVSDTSVQKA 945
            ...::..|.|::..|
 Worm   367 PTIIELYSRTTLPSA 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808 59/225 (26%)
Astacin 527..721 CDD:279708 57/218 (26%)
CUB 723..836 CDD:294042 24/119 (20%)
CUB 840..951 CDD:278839 20/108 (19%)
FXa_inhibition 958..993 CDD:291342
CUB 997..1111 CDD:278839
FXa_inhibition 1118..1153 CDD:291342
CUB 1158..1267 CDD:278839
CUB 1271..1390 CDD:238001
nas-19NP_505893.2 Astacin 48..230 CDD:279708 56/214 (26%)
ZnMc 53..228 CDD:294052 53/207 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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