DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-17

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_505892.1	Gene:	nas-17 / 186923	WormBaseID:	WBGene00003536	Length:	448	Species:	Caenorhabditis elegans

Alignment Length:	587	Identity:	113/587 - (19%)
Similarity:	202/587 - (34%)	Gaps:	194/587 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 AQQQSVPEMD-------LLKAETSKDEEPLRHRVARAVTAKKE-----RIWDYGVIPYEIDGNFS 543
            |.::.|.|.|       ::..:....|..||.....|..:|::     :.|....:.|..:..|:
Worm    40 AIRKDVDEFDSNKGKDGIVDGDIMLTEAQLRILNGTAKRSKRQITKIWKKWPDAKVFYYYENEFT 104

  Fly   544 GIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDK 608
            .:.:.|...||.|..::||:||.|.:..  .|.|.|| .:.||.|::|..| |.|.:..|..|..
Worm   105 SLKRELMSYAMAHISSNTCVKFQESNSA--TNRIRFT-NTGGCASYIGMNG-GEQTLWFGDGCLI 165

  Fly   609 FGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHY 673
            ||..|||:.|.:|.:|.|:|.||:..:.:.:.::.:....|... ..::.....:.::|.|.|.|
Worm   166 FGTAVHEIMHSLGLFHTHSRFDRDNFLSVSYKDVPENMVGNLEK-ETEQTTYNAVPFEYGSTMLY 229

  Fly   674 ARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS 738
            ..|||.:||.      :......:..:|.| |:|..|:...|:.|.| .|.::....:|.:.:||
Worm   230 RYNTFGEGTL------VSKNEDYQKTMGLR-RVSFYDLVNINVRYSC-GCAKSLTCENGGYTNPS 286

  Fly   739 HYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGK 803
                        :|...:                      |.|.:             .|..|.:
Worm   287 ------------NCATCV----------------------CPTGF-------------AGTLCNE 304

  Fly   804 VDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKEC 868
            .....|:..:.    :|        ::|:...|    |...|:       ::.||.|.||
Worm   305 APSNTIKLTAE----SY--------WKGYWVNF----GYSTSI-------QTTNYYLAYL----- 341

  Fly   869 VWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMY 933
             | ||.|....:.:|....   :..:|.|.                  |.|          |.:.
Worm   342 -W-ITAPADKTIEVKIMDL---SGFTCSYG------------------CNY----------NGVE 373

  Fly   934 VKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACG 998
            ||::.|..:                                             ::...|   |.
Worm   374 VKYMGDPRI---------------------------------------------TNPLRC---CA 390

  Fly   999 GVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKH---RISLNFTHFDLEGTAHQQSDCGYDSVT 1060
            ...||.|..|:|...|.          .||...::   ::::::.:.|...:::::|..|||:..
Worm   391 QDTEYLNQVISSKQNPT----------PIVMQQRYGSSKLTIHYRYVDTPLSSNKKSTNGYDNYQ 445

  Fly  1061 VY 1062
            .|
Worm   446 YY 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	56/205 (27%)
		Astacin	527..721	CDD:279708	54/193 (28%)
		CUB	723..836	CDD:294042	12/112 (11%)
		CUB	840..951	CDD:278839	20/110 (18%)
		FXa_inhibition	958..993	CDD:291342	0/34 (0%)
		CUB	997..1111	CDD:278839	15/69 (22%)
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-17	NP_505892.1	Astacin	88..271	CDD:279708	55/195 (28%)
nas-17	NP_505892.1	ZnMc_astacin_like	92..267	CDD:239807	52/186 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810