DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-1

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_499768.2	Gene:	nas-1 / 185811	WormBaseID:	WBGene00003520	Length:	270	Species:	Caenorhabditis elegans

Alignment Length:	205	Identity:	70/205 - (34%)
Similarity:	105/205 - (51%)	Gaps:	15/205 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 AVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSC 584
            ||.|:|:: |..|.:||.:...::...:|:...|...:...|||:||.:.| ...:|||.. :..
Worm    72 AVAAEKDK-WPNGRVPYILSAAYTSAQRAVLARAFDTYAKRTCIRFVPKSP-ADKDYIVIQ-KLD 133

  Fly   585 GCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYN 649
            ||.:...:.| |.|.:|:...|..:..::|||.||:||.|||.|.||:.:|.|.:.|:::|.:.:
Worm   134 GCYADFSRVG-GRQQVSLADECIDYATIIHELMHVIGFIHEHQREDRDSYVSILYQNVIQGANTD 197

  Fly   650 FNMLSPDEVDSLGMAYDYDSIMHYARNTFS---KGTYLDTILPIEMKGRKRPEI-GQRLRLSQGD 710
            |:.||...:...|..|||.|||||..|..|   |.|       ||.|......| |:....|..|
Worm   198 FDKLSNLGLSYYGEHYDYSSIMHYEANEGSRNGKNT-------IEAKNSHFTAIMGKASDFSTSD 255

  Fly   711 IAQANLLYKC 720
            :.:.|..|||
Worm   256 LRRVNRAYKC 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	70/205 (34%)
		Astacin	527..721	CDD:279708	66/198 (33%)
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-1	NP_499768.2	Astacin	79..266	CDD:279708	66/198 (33%)
nas-1	NP_499768.2	ZnMc_astacin_like	82..263	CDD:239807	62/190 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810