DRSC/TRiP Functional Genomics Resources

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Protein Alignment tok and nas-28

DIOPT Version :10

Sequence 1:NP_476879.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_498342.3 Gene:nas-28 / 185658 WormBaseID:WBGene00003546 Length:497 Species:Caenorhabditis elegans


Alignment Length:408 Identity:108/408 - (26%)
Similarity:184/408 - (45%) Gaps:78/408 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 VNHSPPGFNQSQQAQQ--QSVPEMDLLKAETSKDEEPLRHRVARAV-----TAKKERI------W 529
            :|:.|.. ||:::.::  |.:.|. ..:::...:|:..:| :|.|:     .:|::.|      |
 Worm    69 LNYGPKN-NQTKKFEELNQDINEY-TFESDIMLNEKQAKH-IATAIENGNYRSKRQAIVDTTNFW 130

  Fly   530 DYGV-IPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKR 593
            ...| |.|:.|...|..:.|..:.|::.|.:::|:.|.|   :.:....:|...:.||.|:|||:
 Worm   131 SVSVPIFYQFDTKLSATNIANVRKAIQFWNDNSCLSFKE---DNNAKNRLFLSSAGGCWSYVGKQ 192

  Fly   594 GNGP-QAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDE 657
            .:.| |.:|:|.|||.||...|||.|.:||||:.:|.||:.:|.::.:||:..|.|||..::.|:
 Worm   193 VDMPYQMVSVGPNCDTFGTATHELMHAIGFWHQQSRADRDNYVYVDFSNIIPSQAYNFQKMAVDQ 257

  Fly   658 VDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLY---- 718
            ...|.:.|||.|:|.|....|:..:...|||..| .|.:. .:|||...:..||...|.||    
 Worm   258 AQLLNLPYDYGSVMQYYPYAFAVDSSKYTILAKE-NGFQN-SMGQREAPAFSDIIGVNKLYNCTS 320

  Fly   719 ------KCPKCGRTFQESSGIFASPSHYT--------------------------------AG-- 743
                  ||..||.|...:......|.::|                                ||  
 Worm   321 QCKIQMKCSNCGITDSRNCNQCKCPRYFTGASCDSLPSGTAPNCNGAVLQATSSWETFDAKAGDP 385

  Fly   744 -ALSNETE---HCEWRITATYGERVELKLEN--MNIFKSNNCETDYLEIRDGYFEKSPLIGRF-- 800
             :.|:.|:   :|.|.|.|..|:::|.|:..  :.......|....:|:..|.|:   |.|..  
 Worm   386 SSFSSSTDNSTNCYWHIKAPEGQQIEFKMTKTPLAAICMQECPWQSIEVNLGKFD---LFGMITC 447

  Fly   801 CGKVDKEVIRTESSRMLL 818
            |..:..:|..:|.:.:.|
 Worm   448 CDTILNQVFTSELNMIAL 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_476879.1 ZnMc_BMP1_TLD 520..721 CDD:239808 72/223 (32%)
CUB 723..836 CDD:412131 26/138 (19%)
CUB 840..951 CDD:395345
FXa_inhibition 958..993 CDD:464251
CUB 997..1111 CDD:395345
FXa_inhibition 1118..1153 CDD:464251
CUB 1158..1267 CDD:395345
CUB 1271..1390 CDD:238001
nas-28NP_498342.3 ZnMc_astacin_like 135..316 CDD:239807 64/185 (35%)
CUB 393..480 CDD:214483 17/76 (22%)
Blue background indicates that the domain is not in the aligned region.

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