DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-24

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_506409.2	Gene:	nas-24 / 184744	WormBaseID:	WBGene00003543	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	89/373 - (23%)
Similarity:	149/373 - (39%)	Gaps:	76/373 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 RAVTAKKERI---WDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFT 580
            :.|..:.||:   |..|.|.|....|.:.: |...|.|:.:..|.|||||.| ||.......:||
Worm    37 KRVKREFERLGSKWLGGTINYYYADNNNSV-KEKVKSAIAYIANHTCIKFNE-DPTHWQRLKIFT 99

  Fly   581 VRSCGCCSFVGKRGN-----GPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHN 640
            .....|.|.:|..|.     |..::..|. |...|.:|||..|.:|.:||||||||:..:.:
Worm   100 SELSHCRSTIGAPGTRSGSAGELSMETGW-CANIGSIVHEFSHSLGRYHEHTRPDRDNSLKV--- 160

  Fly   641 NIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLR 705
               ...||.... .|..:.::...:::.|||.|..:.:..|    .:.|.:|:.:.  .:|.| |
Worm   161 ---TSTDYEARP-RPWGMTTMYGPFEHGSIMMYHSSNYGVG----KMEPYDMEYKN--TMGSR-R 214

  Fly   706 LSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTA--------GALSNE-TEHCEWRITATYG 761
            ::..|:.:.|..|.| .|....:..:|.:.|||..:.        |.|.|| .:...:.:.||||
Worm   215 VTFYDMYKINQYYGC-GCSTQLECKNGGYTSPSDCSRCNCPKGFFGKLCNERRQQDSYELKATYG 278

  Fly   762 --------------------------------ERVELKLENM-NIFKSNNCETDYLEI--RDGYF 791
                                            ..:|:.:|.: |:..:..|..:.:||  |:...
Worm   279 RWQTQTISFNYKPEPVSDGFYSTFVYITGEANSTIEITMEGLENVICTAGCTWNGVEIKSREDSR 343

  Fly   792 EKSPLIGRFCGKVD---KEVIRTESSRMLLTYVNTHRIEGFRGFKAEF 836
            ..||::   |.|.:   |:|.::..:..::...:.........||..|
Worm   344 ITSPVM---CCKDEPLYKKVFKSLHNPTIIELYSKETAPSTATFKYRF 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	59/208 (28%)
		Astacin	527..721	CDD:279708	57/201 (28%)
		CUB	723..836	CDD:294042	28/159 (18%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-24	NP_506409.2	Astacin	49..231	CDD:279708	57/199 (29%)
nas-24	NP_506409.2	ZnMc	52..227	CDD:294052	54/191 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810